Implementing Neurosurgery and Cesium-131 Brachytherapy in Veterinary Medicine: A Veterinary Case Study with a Review of Clinical Usage of Cesium-131 for Brain Tumors in Human Patients and Opportunities for Translational Research
This article explores the implementation of Cesium-131 brachytherapy in veterinary academia, challenging the prevailing use of external beam therapy for small animal brain tumors. The authors report on the first ever canine patient treated with Cesium-131. While recent advances like intensity-modula...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-04-01
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| Series: | Radiation |
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| Online Access: | https://www.mdpi.com/2673-592X/5/2/13 |
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| author | Isabelle F. Vanhaezebrouck R. Timothy Bentley Alex Georgiades Susan Arnold Joshua A. Young Nathan Claus Laura Danaher Joshua B. Klutzke Matthew L. Scarpelli |
| author_facet | Isabelle F. Vanhaezebrouck R. Timothy Bentley Alex Georgiades Susan Arnold Joshua A. Young Nathan Claus Laura Danaher Joshua B. Klutzke Matthew L. Scarpelli |
| author_sort | Isabelle F. Vanhaezebrouck |
| collection | DOAJ |
| description | This article explores the implementation of Cesium-131 brachytherapy in veterinary academia, challenging the prevailing use of external beam therapy for small animal brain tumors. The authors report on the first ever canine patient treated with Cesium-131. While recent advances like intensity-modulated and stereotactic radiation therapies gain ground, brachytherapy remains underutilized in veterinary practice, primarily due to regulatory hurdles. In contrast, Cesium-131 brachytherapy, widely adopted in human medicine for neoplasia within the brain, presents advantages such as a short half-life, low kilovolt emission, and enhanced safety. Motivated by the need to eliminate post-surgery radiation delays, our academic center undertakes Cesium-131 brachytherapy for small animals, aiming to gather preliminary clinical data on disease-free intervals and survival rates. Comparative analyses against historical external beam therapy data may offer insights applicable to the human neuro-radiation community. Additionally, the technique’s implementation could initiate preclinical platform for combined intracavitary treatments, particularly immunotherapy, leveraging brachytherapy’s spatial dose distribution heterogeneity to influence the tumor microenvironment and enhance the immune response. The authors outline the adaptation of the technique on a canine glioma patient to provide preliminary feasibility results, describe the principal indications and outcomes of Cesium-131 for human brain tumors, and discuss prospects for advancing veterinary neuro-brachytherapy. |
| format | Article |
| id | doaj-art-82dff2a6154b4d8387113038320bb0eb |
| institution | Kabale University |
| issn | 2673-592X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Radiation |
| spelling | doaj-art-82dff2a6154b4d8387113038320bb0eb2025-08-20T03:29:44ZengMDPI AGRadiation2673-592X2025-04-01521310.3390/radiation5020013Implementing Neurosurgery and Cesium-131 Brachytherapy in Veterinary Medicine: A Veterinary Case Study with a Review of Clinical Usage of Cesium-131 for Brain Tumors in Human Patients and Opportunities for Translational ResearchIsabelle F. Vanhaezebrouck0R. Timothy Bentley1Alex Georgiades2Susan Arnold3Joshua A. Young4Nathan Claus5Laura Danaher6Joshua B. Klutzke7Matthew L. Scarpelli8Department of Radiation Oncology, Medical Center, University of Southwestern, Dallas, TX 75390, USASchool of Veterinary Science, University of Liverpool, Neston CH64 7TE, UKSink Cancer Physics, Columbus, OH 47203, USACollege of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USAEnvironmental Health and Safety, University of Yale, New Haven, CT 06510, USACollege of health and Human Sciences, Purdue University, Lafayette, IN 47906, USACollege of Veterinary Medicine, Purdue University, Lafayette, IN 47906, USACollege of Veterinary Medicine, Purdue University, Lafayette, IN 47906, USACollege of health and Human Sciences, Purdue University, Lafayette, IN 47906, USAThis article explores the implementation of Cesium-131 brachytherapy in veterinary academia, challenging the prevailing use of external beam therapy for small animal brain tumors. The authors report on the first ever canine patient treated with Cesium-131. While recent advances like intensity-modulated and stereotactic radiation therapies gain ground, brachytherapy remains underutilized in veterinary practice, primarily due to regulatory hurdles. In contrast, Cesium-131 brachytherapy, widely adopted in human medicine for neoplasia within the brain, presents advantages such as a short half-life, low kilovolt emission, and enhanced safety. Motivated by the need to eliminate post-surgery radiation delays, our academic center undertakes Cesium-131 brachytherapy for small animals, aiming to gather preliminary clinical data on disease-free intervals and survival rates. Comparative analyses against historical external beam therapy data may offer insights applicable to the human neuro-radiation community. Additionally, the technique’s implementation could initiate preclinical platform for combined intracavitary treatments, particularly immunotherapy, leveraging brachytherapy’s spatial dose distribution heterogeneity to influence the tumor microenvironment and enhance the immune response. The authors outline the adaptation of the technique on a canine glioma patient to provide preliminary feasibility results, describe the principal indications and outcomes of Cesium-131 for human brain tumors, and discuss prospects for advancing veterinary neuro-brachytherapy.https://www.mdpi.com/2673-592X/5/2/13brain tumorsbrachytherapyCesium-131caninepreclinical |
| spellingShingle | Isabelle F. Vanhaezebrouck R. Timothy Bentley Alex Georgiades Susan Arnold Joshua A. Young Nathan Claus Laura Danaher Joshua B. Klutzke Matthew L. Scarpelli Implementing Neurosurgery and Cesium-131 Brachytherapy in Veterinary Medicine: A Veterinary Case Study with a Review of Clinical Usage of Cesium-131 for Brain Tumors in Human Patients and Opportunities for Translational Research Radiation brain tumors brachytherapy Cesium-131 canine preclinical |
| title | Implementing Neurosurgery and Cesium-131 Brachytherapy in Veterinary Medicine: A Veterinary Case Study with a Review of Clinical Usage of Cesium-131 for Brain Tumors in Human Patients and Opportunities for Translational Research |
| title_full | Implementing Neurosurgery and Cesium-131 Brachytherapy in Veterinary Medicine: A Veterinary Case Study with a Review of Clinical Usage of Cesium-131 for Brain Tumors in Human Patients and Opportunities for Translational Research |
| title_fullStr | Implementing Neurosurgery and Cesium-131 Brachytherapy in Veterinary Medicine: A Veterinary Case Study with a Review of Clinical Usage of Cesium-131 for Brain Tumors in Human Patients and Opportunities for Translational Research |
| title_full_unstemmed | Implementing Neurosurgery and Cesium-131 Brachytherapy in Veterinary Medicine: A Veterinary Case Study with a Review of Clinical Usage of Cesium-131 for Brain Tumors in Human Patients and Opportunities for Translational Research |
| title_short | Implementing Neurosurgery and Cesium-131 Brachytherapy in Veterinary Medicine: A Veterinary Case Study with a Review of Clinical Usage of Cesium-131 for Brain Tumors in Human Patients and Opportunities for Translational Research |
| title_sort | implementing neurosurgery and cesium 131 brachytherapy in veterinary medicine a veterinary case study with a review of clinical usage of cesium 131 for brain tumors in human patients and opportunities for translational research |
| topic | brain tumors brachytherapy Cesium-131 canine preclinical |
| url | https://www.mdpi.com/2673-592X/5/2/13 |
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