Evaluation of the Effects of Different Crosslinking Technologies on Hyaluronic Acid Behavior-study of Five Hyaluronic Acid Gels Available in Iran Market
Background The rheologic, mechanical, and pharmacological characteristics of hyaluronic acid (HA) gels vary in terms of their specific crosslinking technologies. Objective To evaluate the various characteristics of selected HA gels available in Iran, using simple, inexpensive, and reproducible exper...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Guilan University of Medical Sciences
2023-07-01
|
| Series: | مجله دانشگاه علوم پزشکی گیلان |
| Subjects: | |
| Online Access: | http://journal.gums.ac.ir/article-1-2568-en.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850269240138924032 |
|---|---|
| author | Mehdi Aghsami Marjan Shariatpanahi Hamed Montazeri Negar Mottaghi-Dastjerdi |
| author_facet | Mehdi Aghsami Marjan Shariatpanahi Hamed Montazeri Negar Mottaghi-Dastjerdi |
| author_sort | Mehdi Aghsami |
| collection | DOAJ |
| description | Background The rheologic, mechanical, and pharmacological characteristics of hyaluronic acid (HA) gels vary in terms of their specific crosslinking technologies.
Objective To evaluate the various characteristics of selected HA gels available in Iran, using simple, inexpensive, and reproducible experimental tests are necessary to better understand their appropriateness for specific indications.
Methods The HA gels produced by various crosslinking technologies were evaluated by three experiments, including cohesivity, resistance to stretch, and microscopic examination. The gels subjected to these experiments in this study included Neuramis, Desirial, Belotero, Restylane, and Juvéderm.
Results We found that cohesivity was different among the gels so that Desirial was the least cohesive and Belotero was the most cohesive gel. Other HA gels were observed as partially cohesive. The resistance to stretch test confirmed the cohesivity results and Belotero had the most significant resistance. Microscopic examination of the HA gels showed HA particles of varying distribution and size. Belotero and Desirial were the gels with no particles visible under the microscope.
Conclusion Simple and inexpensive laboratory tests help to understand the way that they can affect the specific gel performance, and may be beneficial for physicians to decide on the best product for a particular therapeutic indication. |
| format | Article |
| id | doaj-art-82dfeb2da22e42cc997ba130b534d112 |
| institution | OA Journals |
| issn | 2008-4048 2008-4056 |
| language | fas |
| publishDate | 2023-07-01 |
| publisher | Guilan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشگاه علوم پزشکی گیلان |
| spelling | doaj-art-82dfeb2da22e42cc997ba130b534d1122025-08-20T01:53:11ZfasGuilan University of Medical Sciencesمجله دانشگاه علوم پزشکی گیلان2008-40482008-40562023-07-01322116127Evaluation of the Effects of Different Crosslinking Technologies on Hyaluronic Acid Behavior-study of Five Hyaluronic Acid Gels Available in Iran MarketMehdi Aghsami0Marjan Shariatpanahi1Hamed Montazeri2Negar Mottaghi-Dastjerdi3 Department of Pharmacology and Toxicology, School of Pharmacy, Iran University of Medical Sciences, Tehran, Iran. Department of Pharmacology and Toxicology, School of Pharmacy, Iran University of Medical Sciences, Tehran, Iran. Department of Pharmacognosy and Pharmaceutical Biotechnology, School of Pharmacy, Iran University of Medical Sciences, Tehran, Iran. Department of Pharmacognosy and Pharmaceutical Biotechnology, School of Pharmacy, Iran University of Medical Sciences, Tehran, Iran. Background The rheologic, mechanical, and pharmacological characteristics of hyaluronic acid (HA) gels vary in terms of their specific crosslinking technologies. Objective To evaluate the various characteristics of selected HA gels available in Iran, using simple, inexpensive, and reproducible experimental tests are necessary to better understand their appropriateness for specific indications. Methods The HA gels produced by various crosslinking technologies were evaluated by three experiments, including cohesivity, resistance to stretch, and microscopic examination. The gels subjected to these experiments in this study included Neuramis, Desirial, Belotero, Restylane, and Juvéderm. Results We found that cohesivity was different among the gels so that Desirial was the least cohesive and Belotero was the most cohesive gel. Other HA gels were observed as partially cohesive. The resistance to stretch test confirmed the cohesivity results and Belotero had the most significant resistance. Microscopic examination of the HA gels showed HA particles of varying distribution and size. Belotero and Desirial were the gels with no particles visible under the microscope. Conclusion Simple and inexpensive laboratory tests help to understand the way that they can affect the specific gel performance, and may be beneficial for physicians to decide on the best product for a particular therapeutic indication.http://journal.gums.ac.ir/article-1-2568-en.pdfhyaluronic acidgelfillercrosslinking |
| spellingShingle | Mehdi Aghsami Marjan Shariatpanahi Hamed Montazeri Negar Mottaghi-Dastjerdi Evaluation of the Effects of Different Crosslinking Technologies on Hyaluronic Acid Behavior-study of Five Hyaluronic Acid Gels Available in Iran Market مجله دانشگاه علوم پزشکی گیلان hyaluronic acid gel filler crosslinking |
| title | Evaluation of the Effects of Different Crosslinking Technologies on Hyaluronic Acid Behavior-study of Five Hyaluronic Acid Gels Available in Iran Market |
| title_full | Evaluation of the Effects of Different Crosslinking Technologies on Hyaluronic Acid Behavior-study of Five Hyaluronic Acid Gels Available in Iran Market |
| title_fullStr | Evaluation of the Effects of Different Crosslinking Technologies on Hyaluronic Acid Behavior-study of Five Hyaluronic Acid Gels Available in Iran Market |
| title_full_unstemmed | Evaluation of the Effects of Different Crosslinking Technologies on Hyaluronic Acid Behavior-study of Five Hyaluronic Acid Gels Available in Iran Market |
| title_short | Evaluation of the Effects of Different Crosslinking Technologies on Hyaluronic Acid Behavior-study of Five Hyaluronic Acid Gels Available in Iran Market |
| title_sort | evaluation of the effects of different crosslinking technologies on hyaluronic acid behavior study of five hyaluronic acid gels available in iran market |
| topic | hyaluronic acid gel filler crosslinking |
| url | http://journal.gums.ac.ir/article-1-2568-en.pdf |
| work_keys_str_mv | AT mehdiaghsami evaluationoftheeffectsofdifferentcrosslinkingtechnologiesonhyaluronicacidbehaviorstudyoffivehyaluronicacidgelsavailableiniranmarket AT marjanshariatpanahi evaluationoftheeffectsofdifferentcrosslinkingtechnologiesonhyaluronicacidbehaviorstudyoffivehyaluronicacidgelsavailableiniranmarket AT hamedmontazeri evaluationoftheeffectsofdifferentcrosslinkingtechnologiesonhyaluronicacidbehaviorstudyoffivehyaluronicacidgelsavailableiniranmarket AT negarmottaghidastjerdi evaluationoftheeffectsofdifferentcrosslinkingtechnologiesonhyaluronicacidbehaviorstudyoffivehyaluronicacidgelsavailableiniranmarket |