Physical and drug- releasing properties of a cement containing simvastatin (SimCeram)
Abstract Background This in vitro study compared the physical characteristics and drug release patterns of a bioactive cement containing with 0.1 μM Simvastatin (SimCeram) with mineral trioxide aggregate (MTA; Angelus, Brazil). Methods SimCeram, a calcium silicate-based cement was prepared with the...
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| Language: | English |
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BMC
2025-05-01
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| Series: | BMC Oral Health |
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| Online Access: | https://doi.org/10.1186/s12903-025-06045-8 |
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| author | Iman Parisay Morva Moodi Marzieh Boskabady Hossein Bagheri Roshanak Salari Melika Hoseinzadeh |
| author_facet | Iman Parisay Morva Moodi Marzieh Boskabady Hossein Bagheri Roshanak Salari Melika Hoseinzadeh |
| author_sort | Iman Parisay |
| collection | DOAJ |
| description | Abstract Background This in vitro study compared the physical characteristics and drug release patterns of a bioactive cement containing with 0.1 μM Simvastatin (SimCeram) with mineral trioxide aggregate (MTA; Angelus, Brazil). Methods SimCeram, a calcium silicate-based cement was prepared with the powder composition of 25 wt% silicon-doped hydroxyapatite, 25 wt% strontium-doped hydroxyapatite, and 50 wt% tricalcium silicate/dicalcium silicate. SimCeram liquid contained 0.1 μM dissolved in distilled water. After preparing SimCeram and MTA, the initial setting time of cements was determined with a Gillmore needle. Compressive strength was measured at 1 h, 1 day, and 1 week using a Universal Testing Machine. Cement solubility was assessed according to ISO 6876 after one day, two, and four weeks. Calcium ion release was measured with an ICP-AES device, and simvastatin release was also examined using a UV-spectrophotometer at 238 nm. Results MTA setting time was significantly shorter (12.33 ± 0.57 min) compared to SimCeram (36.33 ± 1.15 min; P < 0.001). MTA exhibited significantly higher compressive strength than SimCeram after 1 h and 1 day (P < 0.05). However, after 1 week, the compressive strength of SimCeram (10.82 ± 1.93 MPa) surpassed that of MTA (6.79 ± 3.24 MPa; P = 0.009). SimCeram showed greater calcium ion release and solubility throughout all time points tested compared to MTA (P < 0.05). Simvastatin release demonstrated an initial burst after 1 h and reached a plateau after 24 h. Conclusion SimCeram showed higher compressive strength and calcium release compared to MTA. Given simvastatin's beneficial properties—such as anti-inflammatory effects, angiogenesis promotion, and the ability to induce differentiation of dental pulp stem cells—along with the significant calcium ion release from the calcium silicate-based component of the cement, SimCeram could be a promising material for vital pulp therapy. |
| format | Article |
| id | doaj-art-82ddf85f7ca8499f821d6d4f40778e67 |
| institution | OA Journals |
| issn | 1472-6831 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj-art-82ddf85f7ca8499f821d6d4f40778e672025-08-20T02:15:01ZengBMCBMC Oral Health1472-68312025-05-0125111010.1186/s12903-025-06045-8Physical and drug- releasing properties of a cement containing simvastatin (SimCeram)Iman Parisay0Morva Moodi1Marzieh Boskabady2Hossein Bagheri3Roshanak Salari4Melika Hoseinzadeh5Department of Pediatric Dentistry, Faculty of Dentistry, Mashhad University of Medical SciencesDepartment of Pediatric Dentistry, Faculty of Dentistry, Gorgan University of Medical SciencesDepartment of Pediatric Dentistry, Faculty of Dentistry, Mashhad University of Medical SciencesDental Materials Research Center, Mashhad University of Medical SciencesDepartment of Clinical Persian Pharmacy, School of Persian and Complementary Medicine, Mashhad University of Medical SciencesDental Research Center, Mashhad University of Medical SciencesAbstract Background This in vitro study compared the physical characteristics and drug release patterns of a bioactive cement containing with 0.1 μM Simvastatin (SimCeram) with mineral trioxide aggregate (MTA; Angelus, Brazil). Methods SimCeram, a calcium silicate-based cement was prepared with the powder composition of 25 wt% silicon-doped hydroxyapatite, 25 wt% strontium-doped hydroxyapatite, and 50 wt% tricalcium silicate/dicalcium silicate. SimCeram liquid contained 0.1 μM dissolved in distilled water. After preparing SimCeram and MTA, the initial setting time of cements was determined with a Gillmore needle. Compressive strength was measured at 1 h, 1 day, and 1 week using a Universal Testing Machine. Cement solubility was assessed according to ISO 6876 after one day, two, and four weeks. Calcium ion release was measured with an ICP-AES device, and simvastatin release was also examined using a UV-spectrophotometer at 238 nm. Results MTA setting time was significantly shorter (12.33 ± 0.57 min) compared to SimCeram (36.33 ± 1.15 min; P < 0.001). MTA exhibited significantly higher compressive strength than SimCeram after 1 h and 1 day (P < 0.05). However, after 1 week, the compressive strength of SimCeram (10.82 ± 1.93 MPa) surpassed that of MTA (6.79 ± 3.24 MPa; P = 0.009). SimCeram showed greater calcium ion release and solubility throughout all time points tested compared to MTA (P < 0.05). Simvastatin release demonstrated an initial burst after 1 h and reached a plateau after 24 h. Conclusion SimCeram showed higher compressive strength and calcium release compared to MTA. Given simvastatin's beneficial properties—such as anti-inflammatory effects, angiogenesis promotion, and the ability to induce differentiation of dental pulp stem cells—along with the significant calcium ion release from the calcium silicate-based component of the cement, SimCeram could be a promising material for vital pulp therapy.https://doi.org/10.1186/s12903-025-06045-8Compressive strengthDrug liberationHydroxyapatitesMineral trioxide aggregateDental cementsSimvastatin |
| spellingShingle | Iman Parisay Morva Moodi Marzieh Boskabady Hossein Bagheri Roshanak Salari Melika Hoseinzadeh Physical and drug- releasing properties of a cement containing simvastatin (SimCeram) BMC Oral Health Compressive strength Drug liberation Hydroxyapatites Mineral trioxide aggregate Dental cements Simvastatin |
| title | Physical and drug- releasing properties of a cement containing simvastatin (SimCeram) |
| title_full | Physical and drug- releasing properties of a cement containing simvastatin (SimCeram) |
| title_fullStr | Physical and drug- releasing properties of a cement containing simvastatin (SimCeram) |
| title_full_unstemmed | Physical and drug- releasing properties of a cement containing simvastatin (SimCeram) |
| title_short | Physical and drug- releasing properties of a cement containing simvastatin (SimCeram) |
| title_sort | physical and drug releasing properties of a cement containing simvastatin simceram |
| topic | Compressive strength Drug liberation Hydroxyapatites Mineral trioxide aggregate Dental cements Simvastatin |
| url | https://doi.org/10.1186/s12903-025-06045-8 |
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