Recent advances in cell membrane-coated porphyrin-based nanoscale MOFs for enhanced photodynamic therapy
Porphyrins-based nanoscale metal-organic frameworks (nMOFs) has been widely utilized to kills tumor cells by generating cytotoxic reactive oxygen species (ROS). However, porphyrin based nMOFs (por-nMOFs) still face challenges such as rapid immune clearance and weak tumor targeting. Researchers have...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1505212/full |
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| author | Yutao Zou Junjie Wu Qiuyun Zhang Jiayi Chen Xuanxuan Luo Yijie Qu Rui Xia Weiqi Wang Xiaohua Zheng |
| author_facet | Yutao Zou Junjie Wu Qiuyun Zhang Jiayi Chen Xuanxuan Luo Yijie Qu Rui Xia Weiqi Wang Xiaohua Zheng |
| author_sort | Yutao Zou |
| collection | DOAJ |
| description | Porphyrins-based nanoscale metal-organic frameworks (nMOFs) has been widely utilized to kills tumor cells by generating cytotoxic reactive oxygen species (ROS). However, porphyrin based nMOFs (por-nMOFs) still face challenges such as rapid immune clearance and weak tumor targeting. Researchers have discovered that using a top-down biomimetic strategy, where nMOFs are coated with cell membranes, can promote long blood circulation, evade the reticuloendothelial system, and improve cancer cell targeting, thereby significantly enhancing the photodynamic therapy (PDT) effect of nMOFs. This review summarizes the recent work on different cell membranes-coated por-nMOFs for enhanced tumor PDT. This review details the changes in physicochemical properties, enhanced homotypic cancer cell-selective endocytosis, improved tumor tissue targeting, and increased cytotoxicity and effective in vivo tumor suppression after the nMOFs are wrapped with cell membranes. Additionally, this review compares the biological functions of various types of cell membranes, including cancer cell membranes, red blood cell membranes, aptamer-modified red blood cell membranes, and hybrid membranes from the fusion of cancer and immune cells. The review highlights the enhanced immunogenic cell death function when using hybrid membranes derived from the fusion of cancer and immune cell membranes. By summarizing the augmented PDT effects and the combined antitumor outcomes with other therapeutic modalities, this review aims to provide new insights into the biomedical applications of por-nMOFs and offer more references for the preclinical application of porphyrin-based photosensitizers. |
| format | Article |
| id | doaj-art-82dde5277bf9445bbc43c1b975c49c5b |
| institution | OA Journals |
| issn | 1663-9812 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-82dde5277bf9445bbc43c1b975c49c5b2025-08-20T02:30:32ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-12-011510.3389/fphar.2024.15052121505212Recent advances in cell membrane-coated porphyrin-based nanoscale MOFs for enhanced photodynamic therapyYutao Zou0Junjie Wu1Qiuyun Zhang2Jiayi Chen3Xuanxuan Luo4Yijie Qu5Rui Xia6Weiqi Wang7Xiaohua Zheng8The People’s Hospital of Danyang, Affiliated Danyang Hospital of Nantong University, Danyang, Jiangsu, ChinaSchool of Pharmacy, Nantong University, Nantong, Jiangsu, ChinaSchool of Pharmacy, Nantong University, Nantong, Jiangsu, ChinaSchool of Pharmacy, Nantong University, Nantong, Jiangsu, ChinaSchool of Pharmacy, Nantong University, Nantong, Jiangsu, ChinaSchool of Pharmacy, Nantong University, Nantong, Jiangsu, ChinaSchool of Public Health, Nantong University, Nantong, Jiangsu, ChinaSchool of Pharmacy, Nantong University, Nantong, Jiangsu, ChinaSchool of Pharmacy, Nantong University, Nantong, Jiangsu, ChinaPorphyrins-based nanoscale metal-organic frameworks (nMOFs) has been widely utilized to kills tumor cells by generating cytotoxic reactive oxygen species (ROS). However, porphyrin based nMOFs (por-nMOFs) still face challenges such as rapid immune clearance and weak tumor targeting. Researchers have discovered that using a top-down biomimetic strategy, where nMOFs are coated with cell membranes, can promote long blood circulation, evade the reticuloendothelial system, and improve cancer cell targeting, thereby significantly enhancing the photodynamic therapy (PDT) effect of nMOFs. This review summarizes the recent work on different cell membranes-coated por-nMOFs for enhanced tumor PDT. This review details the changes in physicochemical properties, enhanced homotypic cancer cell-selective endocytosis, improved tumor tissue targeting, and increased cytotoxicity and effective in vivo tumor suppression after the nMOFs are wrapped with cell membranes. Additionally, this review compares the biological functions of various types of cell membranes, including cancer cell membranes, red blood cell membranes, aptamer-modified red blood cell membranes, and hybrid membranes from the fusion of cancer and immune cells. The review highlights the enhanced immunogenic cell death function when using hybrid membranes derived from the fusion of cancer and immune cell membranes. By summarizing the augmented PDT effects and the combined antitumor outcomes with other therapeutic modalities, this review aims to provide new insights into the biomedical applications of por-nMOFs and offer more references for the preclinical application of porphyrin-based photosensitizers.https://www.frontiersin.org/articles/10.3389/fphar.2024.1505212/fullphotodynamic therapyporphyrinmetal-organic frameworkscancer cell membranesred blood cell membranes |
| spellingShingle | Yutao Zou Junjie Wu Qiuyun Zhang Jiayi Chen Xuanxuan Luo Yijie Qu Rui Xia Weiqi Wang Xiaohua Zheng Recent advances in cell membrane-coated porphyrin-based nanoscale MOFs for enhanced photodynamic therapy Frontiers in Pharmacology photodynamic therapy porphyrin metal-organic frameworks cancer cell membranes red blood cell membranes |
| title | Recent advances in cell membrane-coated porphyrin-based nanoscale MOFs for enhanced photodynamic therapy |
| title_full | Recent advances in cell membrane-coated porphyrin-based nanoscale MOFs for enhanced photodynamic therapy |
| title_fullStr | Recent advances in cell membrane-coated porphyrin-based nanoscale MOFs for enhanced photodynamic therapy |
| title_full_unstemmed | Recent advances in cell membrane-coated porphyrin-based nanoscale MOFs for enhanced photodynamic therapy |
| title_short | Recent advances in cell membrane-coated porphyrin-based nanoscale MOFs for enhanced photodynamic therapy |
| title_sort | recent advances in cell membrane coated porphyrin based nanoscale mofs for enhanced photodynamic therapy |
| topic | photodynamic therapy porphyrin metal-organic frameworks cancer cell membranes red blood cell membranes |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1505212/full |
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