Complete Response to Sorafenib Rechallenge in a Patient with Metastatic Renal Cell Carcinoma
A 79-year-old Japanese man underwent a medical examination for hoarseness. Computed tomography revealed a left renal tumor, and radical nephrectomy was performed. The tumor was a clear cell carcinoma. Fourteen months after the operation, the tumor had metastasized to the spleen, right lung, and retr...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2017/2648471 |
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| author | Ryo Kasahara Noboru Nakaigawa Kazuki Kobayashi |
| author_facet | Ryo Kasahara Noboru Nakaigawa Kazuki Kobayashi |
| author_sort | Ryo Kasahara |
| collection | DOAJ |
| description | A 79-year-old Japanese man underwent a medical examination for hoarseness. Computed tomography revealed a left renal tumor, and radical nephrectomy was performed. The tumor was a clear cell carcinoma. Fourteen months after the operation, the tumor had metastasized to the spleen, right lung, and retroperitoneal lymph nodes. We initiated molecular targeted therapy sequentially with sorafenib, sunitinib, and axitinib and then conducted a rechallenge with sorafenib. His metastatic lesions had completely vanished 5 months after initiation of the rechallenge. Ten months after the rechallenge, lumbar vertebral body metastasis appeared. However, we consider that the sorafenib rechallenge was effective because of the very slow growth of the metastatic lesion, with no other metastasis for 30 months, at the time of writing this report. Approximately 7 years after the first local recurrence, he remained alive, with relatively normal daily functioning. |
| format | Article |
| id | doaj-art-82db94ea60dd4a07b91101806ea40648 |
| institution | OA Journals |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-82db94ea60dd4a07b91101806ea406482025-08-20T02:08:46ZengWileyCase Reports in Oncological Medicine2090-67062090-67142017-01-01201710.1155/2017/26484712648471Complete Response to Sorafenib Rechallenge in a Patient with Metastatic Renal Cell CarcinomaRyo Kasahara0Noboru Nakaigawa1Kazuki Kobayashi2Department of Urology, Yokosuka Kyosai Hospital, Yokosuka, JapanDepartment of Urology, Yokohama City University Hospital, Yokohama, JapanDepartment of Urology, Yokosuka Kyosai Hospital, Yokosuka, JapanA 79-year-old Japanese man underwent a medical examination for hoarseness. Computed tomography revealed a left renal tumor, and radical nephrectomy was performed. The tumor was a clear cell carcinoma. Fourteen months after the operation, the tumor had metastasized to the spleen, right lung, and retroperitoneal lymph nodes. We initiated molecular targeted therapy sequentially with sorafenib, sunitinib, and axitinib and then conducted a rechallenge with sorafenib. His metastatic lesions had completely vanished 5 months after initiation of the rechallenge. Ten months after the rechallenge, lumbar vertebral body metastasis appeared. However, we consider that the sorafenib rechallenge was effective because of the very slow growth of the metastatic lesion, with no other metastasis for 30 months, at the time of writing this report. Approximately 7 years after the first local recurrence, he remained alive, with relatively normal daily functioning.http://dx.doi.org/10.1155/2017/2648471 |
| spellingShingle | Ryo Kasahara Noboru Nakaigawa Kazuki Kobayashi Complete Response to Sorafenib Rechallenge in a Patient with Metastatic Renal Cell Carcinoma Case Reports in Oncological Medicine |
| title | Complete Response to Sorafenib Rechallenge in a Patient with Metastatic Renal Cell Carcinoma |
| title_full | Complete Response to Sorafenib Rechallenge in a Patient with Metastatic Renal Cell Carcinoma |
| title_fullStr | Complete Response to Sorafenib Rechallenge in a Patient with Metastatic Renal Cell Carcinoma |
| title_full_unstemmed | Complete Response to Sorafenib Rechallenge in a Patient with Metastatic Renal Cell Carcinoma |
| title_short | Complete Response to Sorafenib Rechallenge in a Patient with Metastatic Renal Cell Carcinoma |
| title_sort | complete response to sorafenib rechallenge in a patient with metastatic renal cell carcinoma |
| url | http://dx.doi.org/10.1155/2017/2648471 |
| work_keys_str_mv | AT ryokasahara completeresponsetosorafenibrechallengeinapatientwithmetastaticrenalcellcarcinoma AT noborunakaigawa completeresponsetosorafenibrechallengeinapatientwithmetastaticrenalcellcarcinoma AT kazukikobayashi completeresponsetosorafenibrechallengeinapatientwithmetastaticrenalcellcarcinoma |