Differential Ca2+ handling by isolated synaptic and non-synaptic mitochondria: roles of Ca2+ buffering and efflux

Differential Ca2+ handling by isolated synaptic and non-synaptic mitochondria: roles of Ca2+ buffering and efflux

Mitochondria regulate intracellular calcium ion (Ca2+) signaling by a fine-tuned process of mitochondrial matrix (m) Ca2+ influx, mCa2+ buffering (sequestration) and mCa2+ release (Ca2+ efflux). This process is critically important in the neurosynaptic terminal, where there is a simultaneous high de...

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Bibliographic Details
Main Authors: Jyotsna Mishra, Kyle Bevers, Keguo Li, Armaan Zare, James S. Heisner, Ailing Tong, Wai-Meng Kwok, David F. Stowe, Amadou K. S. Camara
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
synaptic mitochondria
non-synaptic mitochondria
Ca2+ buffering
Ca2+ efflux
bioenergetics
Online Access:https://www.frontiersin.org/articles/10.3389/fnsyn.2025.1562065/full
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