A novel non-invasive treatment in deep burned patients who do not have consent to surgery
One of the common traumatic injuries is burns. In deep burns, the standard of care (SOC) is surgical excision and skin grafting, still, some patients do not have consent to do the surgical procedure because of operation fear, comorbidity disorder, or contraindications for anesthesia. This study appl...
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| Language: | English |
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Elsevier
2025-04-01
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| Series: | Burns Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468912224000804 |
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| author | Seyed Hassan Tavoosi Ali Ahmadabadi Omid Yazarlou Hossain Safari Mahdi Kouhi Noghondar Elaheh Emadi Daryoush Hamidi Alamdari |
| author_facet | Seyed Hassan Tavoosi Ali Ahmadabadi Omid Yazarlou Hossain Safari Mahdi Kouhi Noghondar Elaheh Emadi Daryoush Hamidi Alamdari |
| author_sort | Seyed Hassan Tavoosi |
| collection | DOAJ |
| description | One of the common traumatic injuries is burns. In deep burns, the standard of care (SOC) is surgical excision and skin grafting, still, some patients do not have consent to do the surgical procedure because of operation fear, comorbidity disorder, or contraindications for anesthesia. This study applied a novel repairing gel, also called SUPRAZ, to treat patients with deep burns to achieve outcomes similar to those of SOC. This gel was made from approved biochemical components involved in wound healing mechanisms. Over 18 months, from 2022 to 2024, this controlled single-arm clinical trial including 22 patients aged 4–80 years with deep partial or/and full thickness burns covering 0.5–12 % of their total body surface area was conducted. Despite the emphasis on surgery, these patients did not consent to do surgery. Therefore, repairing gel was applied topically on the burn area. Repairing gel time to heal the area of burns was 24.9 ± 8.5 (mean ± SD; days). The pain subsided after 10–15 min of use. During the 3–12 months follow-up of the patients, there were no signs of hypertrophic scars and keloids. The repairing gel was safe and can be used for patients who do not consent to surgery. Multicenter clinical trials are needed to substantiate the efficacy of repairing gel and achieving comparable long-term results to SOC in deep-burned patients. Trial registration: IRCT20191228045924N6. |
| format | Article |
| id | doaj-art-82cd09cd1a5c490590254bc78968c9e9 |
| institution | OA Journals |
| issn | 2468-9122 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Burns Open |
| spelling | doaj-art-82cd09cd1a5c490590254bc78968c9e92025-08-20T02:08:31ZengElsevierBurns Open2468-91222025-04-011010039210.1016/j.burnso.2024.100392A novel non-invasive treatment in deep burned patients who do not have consent to surgerySeyed Hassan Tavoosi0Ali Ahmadabadi1Omid Yazarlou2Hossain Safari3Mahdi Kouhi Noghondar4Elaheh Emadi5Daryoush Hamidi Alamdari6Department of Burns and Reconstructive Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Burns and Reconstructive Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Burns and Reconstructive Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Burns and Reconstructive Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, IranDepartement of Microbiology, Imam Reza Hospital, Mashhad University of Medical Sciences in Iran, IranVascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Burns and Reconstructive Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran; Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Corresponding author at: Clinical Biochemistry Department, Medical Faculty, Mashhad University of Medical Sciences, Mashhad, Iran.One of the common traumatic injuries is burns. In deep burns, the standard of care (SOC) is surgical excision and skin grafting, still, some patients do not have consent to do the surgical procedure because of operation fear, comorbidity disorder, or contraindications for anesthesia. This study applied a novel repairing gel, also called SUPRAZ, to treat patients with deep burns to achieve outcomes similar to those of SOC. This gel was made from approved biochemical components involved in wound healing mechanisms. Over 18 months, from 2022 to 2024, this controlled single-arm clinical trial including 22 patients aged 4–80 years with deep partial or/and full thickness burns covering 0.5–12 % of their total body surface area was conducted. Despite the emphasis on surgery, these patients did not consent to do surgery. Therefore, repairing gel was applied topically on the burn area. Repairing gel time to heal the area of burns was 24.9 ± 8.5 (mean ± SD; days). The pain subsided after 10–15 min of use. During the 3–12 months follow-up of the patients, there were no signs of hypertrophic scars and keloids. The repairing gel was safe and can be used for patients who do not consent to surgery. Multicenter clinical trials are needed to substantiate the efficacy of repairing gel and achieving comparable long-term results to SOC in deep-burned patients. Trial registration: IRCT20191228045924N6.http://www.sciencedirect.com/science/article/pii/S2468912224000804BurnsRepairing gelNon-invasive treatment |
| spellingShingle | Seyed Hassan Tavoosi Ali Ahmadabadi Omid Yazarlou Hossain Safari Mahdi Kouhi Noghondar Elaheh Emadi Daryoush Hamidi Alamdari A novel non-invasive treatment in deep burned patients who do not have consent to surgery Burns Open Burns Repairing gel Non-invasive treatment |
| title | A novel non-invasive treatment in deep burned patients who do not have consent to surgery |
| title_full | A novel non-invasive treatment in deep burned patients who do not have consent to surgery |
| title_fullStr | A novel non-invasive treatment in deep burned patients who do not have consent to surgery |
| title_full_unstemmed | A novel non-invasive treatment in deep burned patients who do not have consent to surgery |
| title_short | A novel non-invasive treatment in deep burned patients who do not have consent to surgery |
| title_sort | novel non invasive treatment in deep burned patients who do not have consent to surgery |
| topic | Burns Repairing gel Non-invasive treatment |
| url | http://www.sciencedirect.com/science/article/pii/S2468912224000804 |
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