Primary thyroid squamous cell carcinoma with severe respiratory stenosis and endotracheal invasion: a case report with literature review
IntroductionPrimary squamous cell carcinoma of the thyroid (PSCCT) is a rare and highly aggressive malignant tumor with a poor prognosis. Although surgery, chemotherapy and other treatment methods have been reported, the current treatment modality has not reached a consensus. This study discusses th...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1631714/full |
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| author | Xueliang Liu Shang Ma Yuxin Zheng Zeming Xu Hui Hao Hongyan Ma Qian Xu |
| author_facet | Xueliang Liu Shang Ma Yuxin Zheng Zeming Xu Hui Hao Hongyan Ma Qian Xu |
| author_sort | Xueliang Liu |
| collection | DOAJ |
| description | IntroductionPrimary squamous cell carcinoma of the thyroid (PSCCT) is a rare and highly aggressive malignant tumor with a poor prognosis. Although surgery, chemotherapy and other treatment methods have been reported, the current treatment modality has not reached a consensus. This study discusses the diagnosis and treatment of a case of PSCCT with severe respiratory stenosis and endotracheal invasion and reviews the relevant literature. We report the disease of rapidly enlarging mass leading to asphyxiation to raise clinicians’ awareness of this condition.Case presentationWe report a 76-year-old woman presenting with an enlarging right thyroid mass accompanied by severe dyspnea and hoarseness. Computed tomography (CT) scan disclosed a large solid heterogenous nodule with calcification in the right thyroid lobe and prominent adjacent lymph nodes. PSCCT was confirmed by postoperative histopathology and immunohistochemistry. Thyroidectomy with partial tracheectomy and tracheostomy was performed to relieve the patient’s dyspnea. The patient has been discharged after receiving post-operative supportive care.ConclusionClinicians should pay attention to the rapidly enlarging neck mass as it may cause asphyxiation and avoid the loss of treatment opportunities. |
| format | Article |
| id | doaj-art-82ca25fcb5ef49e4aea750ccdb5f403a |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-82ca25fcb5ef49e4aea750ccdb5f403a2025-08-20T03:55:48ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-07-011210.3389/fmed.2025.16317141631714Primary thyroid squamous cell carcinoma with severe respiratory stenosis and endotracheal invasion: a case report with literature reviewXueliang Liu0Shang Ma1Yuxin Zheng2Zeming Xu3Hui Hao4Hongyan Ma5Qian Xu6Department of Thyroid and Breast Surgery, Cangzhou People’s Hospital, Cangzhou, ChinaDepartment of Thyroid and Breast Surgery, Cangzhou People’s Hospital, Cangzhou, ChinaDepartment of Thyroid and Breast Surgery, Cangzhou People’s Hospital, Cangzhou, ChinaDepartment of Thyroid and Breast Surgery, Cangzhou People’s Hospital, Cangzhou, ChinaDepartment of Oncology, Cangzhou People’s Hospital, Cangzhou, ChinaDepartment of Pathology, Cangzhou People’s Hospital, Cangzhou, ChinaDepartment of Anesthesiology, Cangzhou People’s Hospital, Cangzhou, ChinaIntroductionPrimary squamous cell carcinoma of the thyroid (PSCCT) is a rare and highly aggressive malignant tumor with a poor prognosis. Although surgery, chemotherapy and other treatment methods have been reported, the current treatment modality has not reached a consensus. This study discusses the diagnosis and treatment of a case of PSCCT with severe respiratory stenosis and endotracheal invasion and reviews the relevant literature. We report the disease of rapidly enlarging mass leading to asphyxiation to raise clinicians’ awareness of this condition.Case presentationWe report a 76-year-old woman presenting with an enlarging right thyroid mass accompanied by severe dyspnea and hoarseness. Computed tomography (CT) scan disclosed a large solid heterogenous nodule with calcification in the right thyroid lobe and prominent adjacent lymph nodes. PSCCT was confirmed by postoperative histopathology and immunohistochemistry. Thyroidectomy with partial tracheectomy and tracheostomy was performed to relieve the patient’s dyspnea. The patient has been discharged after receiving post-operative supportive care.ConclusionClinicians should pay attention to the rapidly enlarging neck mass as it may cause asphyxiation and avoid the loss of treatment opportunities.https://www.frontiersin.org/articles/10.3389/fmed.2025.1631714/fullthyroid cancerprimary squamous cell carcinomathyroidcase reportrespiratory stenosis |
| spellingShingle | Xueliang Liu Shang Ma Yuxin Zheng Zeming Xu Hui Hao Hongyan Ma Qian Xu Primary thyroid squamous cell carcinoma with severe respiratory stenosis and endotracheal invasion: a case report with literature review Frontiers in Medicine thyroid cancer primary squamous cell carcinoma thyroid case report respiratory stenosis |
| title | Primary thyroid squamous cell carcinoma with severe respiratory stenosis and endotracheal invasion: a case report with literature review |
| title_full | Primary thyroid squamous cell carcinoma with severe respiratory stenosis and endotracheal invasion: a case report with literature review |
| title_fullStr | Primary thyroid squamous cell carcinoma with severe respiratory stenosis and endotracheal invasion: a case report with literature review |
| title_full_unstemmed | Primary thyroid squamous cell carcinoma with severe respiratory stenosis and endotracheal invasion: a case report with literature review |
| title_short | Primary thyroid squamous cell carcinoma with severe respiratory stenosis and endotracheal invasion: a case report with literature review |
| title_sort | primary thyroid squamous cell carcinoma with severe respiratory stenosis and endotracheal invasion a case report with literature review |
| topic | thyroid cancer primary squamous cell carcinoma thyroid case report respiratory stenosis |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1631714/full |
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