Electrochemical Skin Conductance May Be Used to Screen for Diabetic Cardiac Autonomic Neuropathy in a Chinese Population with Diabetes
Aims. This study aimed to assess whether the electrochemical skin conductance (ESC) could be used to screen for diabetic cardiac autonomic neuropathy (DCAN) in a Chinese population with diabetes. Methods. We recruited 75 patients with type 2 diabetes mellitus (T2DM) and 45 controls without diabetes....
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/8289740 |
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| author | Tianyi He Chuan Wang Anju Zuo Pan Liu Ruxing Zhao Wenjuan Li Li Chen Xinguo Hou |
| author_facet | Tianyi He Chuan Wang Anju Zuo Pan Liu Ruxing Zhao Wenjuan Li Li Chen Xinguo Hou |
| author_sort | Tianyi He |
| collection | DOAJ |
| description | Aims. This study aimed to assess whether the electrochemical skin conductance (ESC) could be used to screen for diabetic cardiac autonomic neuropathy (DCAN) in a Chinese population with diabetes. Methods. We recruited 75 patients with type 2 diabetes mellitus (T2DM) and 45 controls without diabetes. DCAN was diagnosed by the cardiovascular autonomic reflex tests (CARTs) as gold standard. In all subjects ESCs of hands and feet were also detected by SUDOSCAN™ as a new screening method. The efficacy was assessed by receiver operating characteristic (ROC) curve analysis. Results. The ESCs of both hands and feet were significantly lower in T2DM patients with DCAN than those without DCAN (67.33±15.37 versus 78.03±13.73, P=0.002, and 57.77±20.99 versus 75.03±11.41, P<0.001). The ROC curve analysis showed the areas under the ROC curve were both 0.75 for ESCs of hands and feet in screening DCAN. And the optimal cut-off values of ESCs, sensitivities, and specificities were 76 μS, 76.7%, and 75.6% for hands and 75 μS, 80.0%, and 60.0% for feet, respectively. Conclusions. ESC measurement is a reliable and feasible method to screen DCAN in the Chinese population with diabetes before further diagnosis with CARTs. |
| format | Article |
| id | doaj-art-82c6ac1ea8464a6db17994261905281d |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-82c6ac1ea8464a6db17994261905281d2025-02-03T01:02:34ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/82897408289740Electrochemical Skin Conductance May Be Used to Screen for Diabetic Cardiac Autonomic Neuropathy in a Chinese Population with DiabetesTianyi He0Chuan Wang1Anju Zuo2Pan Liu3Ruxing Zhao4Wenjuan Li5Li Chen6Xinguo Hou7Department of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, ChinaDepartment of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, ChinaDepartment of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, ChinaDepartment of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, ChinaDepartment of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, ChinaDepartment of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, ChinaDepartment of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, ChinaDepartment of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, ChinaAims. This study aimed to assess whether the electrochemical skin conductance (ESC) could be used to screen for diabetic cardiac autonomic neuropathy (DCAN) in a Chinese population with diabetes. Methods. We recruited 75 patients with type 2 diabetes mellitus (T2DM) and 45 controls without diabetes. DCAN was diagnosed by the cardiovascular autonomic reflex tests (CARTs) as gold standard. In all subjects ESCs of hands and feet were also detected by SUDOSCAN™ as a new screening method. The efficacy was assessed by receiver operating characteristic (ROC) curve analysis. Results. The ESCs of both hands and feet were significantly lower in T2DM patients with DCAN than those without DCAN (67.33±15.37 versus 78.03±13.73, P=0.002, and 57.77±20.99 versus 75.03±11.41, P<0.001). The ROC curve analysis showed the areas under the ROC curve were both 0.75 for ESCs of hands and feet in screening DCAN. And the optimal cut-off values of ESCs, sensitivities, and specificities were 76 μS, 76.7%, and 75.6% for hands and 75 μS, 80.0%, and 60.0% for feet, respectively. Conclusions. ESC measurement is a reliable and feasible method to screen DCAN in the Chinese population with diabetes before further diagnosis with CARTs.http://dx.doi.org/10.1155/2017/8289740 |
| spellingShingle | Tianyi He Chuan Wang Anju Zuo Pan Liu Ruxing Zhao Wenjuan Li Li Chen Xinguo Hou Electrochemical Skin Conductance May Be Used to Screen for Diabetic Cardiac Autonomic Neuropathy in a Chinese Population with Diabetes Journal of Diabetes Research |
| title | Electrochemical Skin Conductance May Be Used to Screen for Diabetic Cardiac Autonomic Neuropathy in a Chinese Population with Diabetes |
| title_full | Electrochemical Skin Conductance May Be Used to Screen for Diabetic Cardiac Autonomic Neuropathy in a Chinese Population with Diabetes |
| title_fullStr | Electrochemical Skin Conductance May Be Used to Screen for Diabetic Cardiac Autonomic Neuropathy in a Chinese Population with Diabetes |
| title_full_unstemmed | Electrochemical Skin Conductance May Be Used to Screen for Diabetic Cardiac Autonomic Neuropathy in a Chinese Population with Diabetes |
| title_short | Electrochemical Skin Conductance May Be Used to Screen for Diabetic Cardiac Autonomic Neuropathy in a Chinese Population with Diabetes |
| title_sort | electrochemical skin conductance may be used to screen for diabetic cardiac autonomic neuropathy in a chinese population with diabetes |
| url | http://dx.doi.org/10.1155/2017/8289740 |
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