Six stabs in the back of proton pump inhibitors
Proton pump inhibitors (PPIs) are the most important class of drugs used for the therapy of acid-dependent diseases and states of the gastrointestinal tract (GIT). In rheumatologic practice, PPIs are an essential drug to treat and prevent upper GIT pathology occurring with the intake of antirheumati...
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2013-06-01
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| Series: | Научно-практическая ревматология |
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| Online Access: | https://rsp.mediar-press.net/rsp/article/view/1658 |
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| author | Andrei Evgenyevich Karateev |
| author_facet | Andrei Evgenyevich Karateev |
| author_sort | Andrei Evgenyevich Karateev |
| collection | DOAJ |
| description | Proton pump inhibitors (PPIs) are the most important class of drugs used for the therapy of acid-dependent diseases and states of the gastrointestinal tract (GIT). In rheumatologic practice, PPIs are an essential drug to treat and prevent upper GIT pathology occurring with the intake of antirheumatic (above all nonsteroidal anti-inflammatory) drugs. PPIs are noteworthy for ease of use, efficacy, and excellent tolerability. Nevertheless, they are able to cause a number of serious class-specific adverse reactions. Some of these complications, such as osteoporosis progression and metabolic effect of methotrexate, may be of great importance for rheumatologic practice. This review is a critical analysis of the data available in the literature on the safety of PPIs and a risk-benefit assessment when they are used |
| format | Article |
| id | doaj-art-82c5609b1c274ca2aae4a0df87abf604 |
| institution | Kabale University |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| publishDate | 2013-06-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj-art-82c5609b1c274ca2aae4a0df87abf6042025-08-20T03:38:12ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922013-06-0151333234010.14412/1995-4484-2013-15091595Six stabs in the back of proton pump inhibitorsAndrei Evgenyevich KarateevProton pump inhibitors (PPIs) are the most important class of drugs used for the therapy of acid-dependent diseases and states of the gastrointestinal tract (GIT). In rheumatologic practice, PPIs are an essential drug to treat and prevent upper GIT pathology occurring with the intake of antirheumatic (above all nonsteroidal anti-inflammatory) drugs. PPIs are noteworthy for ease of use, efficacy, and excellent tolerability. Nevertheless, they are able to cause a number of serious class-specific adverse reactions. Some of these complications, such as osteoporosis progression and metabolic effect of methotrexate, may be of great importance for rheumatologic practice. This review is a critical analysis of the data available in the literature on the safety of PPIs and a risk-benefit assessment when they are usedhttps://rsp.mediar-press.net/rsp/article/view/1658helicobacter pyloriproton pump inhibitorsadverse reactionsenteric infectionspneumoniahelicobacter pyloriosteoporosismethotrexateclopidogrel |
| spellingShingle | Andrei Evgenyevich Karateev Six stabs in the back of proton pump inhibitors Научно-практическая ревматология helicobacter pylori proton pump inhibitors adverse reactions enteric infections pneumonia helicobacter pylori osteoporosis methotrexate clopidogrel |
| title | Six stabs in the back of proton pump inhibitors |
| title_full | Six stabs in the back of proton pump inhibitors |
| title_fullStr | Six stabs in the back of proton pump inhibitors |
| title_full_unstemmed | Six stabs in the back of proton pump inhibitors |
| title_short | Six stabs in the back of proton pump inhibitors |
| title_sort | six stabs in the back of proton pump inhibitors |
| topic | helicobacter pylori proton pump inhibitors adverse reactions enteric infections pneumonia helicobacter pylori osteoporosis methotrexate clopidogrel |
| url | https://rsp.mediar-press.net/rsp/article/view/1658 |
| work_keys_str_mv | AT andreievgenyevichkarateev sixstabsinthebackofprotonpumpinhibitors |