Design and Synthesis of Small Molecules Based on a Substructural Analysis of the Histone Deacetylase Inhibitors TSA and SAHA
Inhibitors of histone deacetylases (HDACs) are patent inducers of differentiation and bear considerable potential as drugs for chemoprevention and treatment of cancer. In this paper, we have investigated three synthetic, inhibitors A1a,b, A2a. Analogue hybrid trichostatine A (TSA), suberoylanilide h...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2011/403129 |
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| _version_ | 1832566835582599168 |
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| author | Lynda Ekou Tchirioua Ekou Javier Garcia Isabelle Opalinski Jean Pierre Gesson |
| author_facet | Lynda Ekou Tchirioua Ekou Javier Garcia Isabelle Opalinski Jean Pierre Gesson |
| author_sort | Lynda Ekou |
| collection | DOAJ |
| description | Inhibitors of histone deacetylases (HDACs) are patent inducers of differentiation and bear considerable potential as drugs for chemoprevention and treatment of cancer. In this paper, we have investigated three synthetic, inhibitors A1a,b, A2a. Analogue hybrid trichostatine A (TSA), suberoylanilide hydroxamic acid SAHA, in order to seek new histone deacetylases (HDACs) inhibitors. |
| format | Article |
| id | doaj-art-82c3704bd4b24635a20202a526a83e50 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-82c3704bd4b24635a20202a526a83e502025-02-03T01:03:03ZengWileyE-Journal of Chemistry0973-49452090-98102011-01-01831394140010.1155/2011/403129Design and Synthesis of Small Molecules Based on a Substructural Analysis of the Histone Deacetylase Inhibitors TSA and SAHALynda Ekou0Tchirioua Ekou1Javier Garcia2Isabelle Opalinski3Jean Pierre Gesson4Université d'Abobo-Adjamé, Laboratoire de Thermodynamique et de Physico Chimie du Milieu, 02 BP 801 Abidjan 02, Cote D'IvoireUniversité d'Abobo-Adjamé, Laboratoire de Thermodynamique et de Physico Chimie du Milieu, 02 BP 801 Abidjan 02, Cote D'IvoireUniversité de Poitiers, UMR-CNRS 6514, Laboratoire de Synthèse et Réactivité des Substances Naturelles, 40 Avenue du Recteur Pineau, 86022 Poitiers Cedex, FranceUniversité de Poitiers, UMR-CNRS 6514, Laboratoire de Synthèse et Réactivité des Substances Naturelles, 40 Avenue du Recteur Pineau, 86022 Poitiers Cedex, FranceUniversité de Poitiers, UMR-CNRS 6514, Laboratoire de Synthèse et Réactivité des Substances Naturelles, 40 Avenue du Recteur Pineau, 86022 Poitiers Cedex, FranceInhibitors of histone deacetylases (HDACs) are patent inducers of differentiation and bear considerable potential as drugs for chemoprevention and treatment of cancer. In this paper, we have investigated three synthetic, inhibitors A1a,b, A2a. Analogue hybrid trichostatine A (TSA), suberoylanilide hydroxamic acid SAHA, in order to seek new histone deacetylases (HDACs) inhibitors.http://dx.doi.org/10.1155/2011/403129 |
| spellingShingle | Lynda Ekou Tchirioua Ekou Javier Garcia Isabelle Opalinski Jean Pierre Gesson Design and Synthesis of Small Molecules Based on a Substructural Analysis of the Histone Deacetylase Inhibitors TSA and SAHA E-Journal of Chemistry |
| title | Design and Synthesis of Small Molecules Based on a Substructural Analysis of the Histone Deacetylase Inhibitors TSA and SAHA |
| title_full | Design and Synthesis of Small Molecules Based on a Substructural Analysis of the Histone Deacetylase Inhibitors TSA and SAHA |
| title_fullStr | Design and Synthesis of Small Molecules Based on a Substructural Analysis of the Histone Deacetylase Inhibitors TSA and SAHA |
| title_full_unstemmed | Design and Synthesis of Small Molecules Based on a Substructural Analysis of the Histone Deacetylase Inhibitors TSA and SAHA |
| title_short | Design and Synthesis of Small Molecules Based on a Substructural Analysis of the Histone Deacetylase Inhibitors TSA and SAHA |
| title_sort | design and synthesis of small molecules based on a substructural analysis of the histone deacetylase inhibitors tsa and saha |
| url | http://dx.doi.org/10.1155/2011/403129 |
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