Emergence of IGH::CCND1 rearrangement and mutations in TP53, BTK, and BCL2 associated with therapy resistance in chronic lymphocytic leukemia

Emergence of IGH::CCND1 rearrangement and mutations in TP53, BTK, and BCL2 associated with therapy resistance in chronic lymphocytic leukemia

Abstract Chronic lymphocytic leukemia (CLL) is an indolent low‐grade B‐cell neoplasm that generally responds well to treatment. Rarely, CLL cases exhibit an IGH::CCND1 rearrangement, presenting a diagnostic challenge in distinguishing between clonal evolution within CLL and an independent mantle cel...

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Bibliographic Details
Main Authors: Qing Wei, Hong Fang, James M. Jing, Roman Segura‐Rivera, L. Jeffrey Medeiros, Wei Wang
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:eJHaem
Subjects:
CLL
IGH:CCND1 rearrangement
mutations
therapy‐resistance
Online Access:https://doi.org/10.1002/jha2.1024
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