Emergence of IGH::CCND1 rearrangement and mutations in TP53, BTK, and BCL2 associated with therapy resistance in chronic lymphocytic leukemia
Abstract Chronic lymphocytic leukemia (CLL) is an indolent low‐grade B‐cell neoplasm that generally responds well to treatment. Rarely, CLL cases exhibit an IGH::CCND1 rearrangement, presenting a diagnostic challenge in distinguishing between clonal evolution within CLL and an independent mantle cel...
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| Format: | Article |
| Language: | English |
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Wiley
2024-12-01
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| Series: | eJHaem |
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| Online Access: | https://doi.org/10.1002/jha2.1024 |
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| author | Qing Wei Hong Fang James M. Jing Roman Segura‐Rivera L. Jeffrey Medeiros Wei Wang |
| author_facet | Qing Wei Hong Fang James M. Jing Roman Segura‐Rivera L. Jeffrey Medeiros Wei Wang |
| author_sort | Qing Wei |
| collection | DOAJ |
| description | Abstract Chronic lymphocytic leukemia (CLL) is an indolent low‐grade B‐cell neoplasm that generally responds well to treatment. Rarely, CLL cases exhibit an IGH::CCND1 rearrangement, presenting a diagnostic challenge in distinguishing between clonal evolution within CLL and an independent mantle cell lymphoma. We report a case of CLL with the emergence of an IGH::CCND1 rearrangement and mutations associated with treatment resistance, including TP53, BTK, and BCL2, during disease progression. Immunophenotypic, cytogenetic, and molecular analyses support that these alterations are secondary events within the CLL clone. This case demonstrates dynamic clonal selection and expansion in response to treatments, which, in turn, contributes to treatment resistance. |
| format | Article |
| id | doaj-art-82c0ea75858a45b3a9801f39dfe1bef2 |
| institution | OA Journals |
| issn | 2688-6146 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | eJHaem |
| spelling | doaj-art-82c0ea75858a45b3a9801f39dfe1bef22025-08-20T01:56:52ZengWileyeJHaem2688-61462024-12-01561265126810.1002/jha2.1024Emergence of IGH::CCND1 rearrangement and mutations in TP53, BTK, and BCL2 associated with therapy resistance in chronic lymphocytic leukemiaQing Wei0Hong Fang1James M. Jing2Roman Segura‐Rivera3L. Jeffrey Medeiros4Wei Wang5Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Abdominal Imaging The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USAAbstract Chronic lymphocytic leukemia (CLL) is an indolent low‐grade B‐cell neoplasm that generally responds well to treatment. Rarely, CLL cases exhibit an IGH::CCND1 rearrangement, presenting a diagnostic challenge in distinguishing between clonal evolution within CLL and an independent mantle cell lymphoma. We report a case of CLL with the emergence of an IGH::CCND1 rearrangement and mutations associated with treatment resistance, including TP53, BTK, and BCL2, during disease progression. Immunophenotypic, cytogenetic, and molecular analyses support that these alterations are secondary events within the CLL clone. This case demonstrates dynamic clonal selection and expansion in response to treatments, which, in turn, contributes to treatment resistance.https://doi.org/10.1002/jha2.1024CLLIGH:CCND1 rearrangementmutationstherapy‐resistance |
| spellingShingle | Qing Wei Hong Fang James M. Jing Roman Segura‐Rivera L. Jeffrey Medeiros Wei Wang Emergence of IGH::CCND1 rearrangement and mutations in TP53, BTK, and BCL2 associated with therapy resistance in chronic lymphocytic leukemia eJHaem CLL IGH:CCND1 rearrangement mutations therapy‐resistance |
| title | Emergence of IGH::CCND1 rearrangement and mutations in TP53, BTK, and BCL2 associated with therapy resistance in chronic lymphocytic leukemia |
| title_full | Emergence of IGH::CCND1 rearrangement and mutations in TP53, BTK, and BCL2 associated with therapy resistance in chronic lymphocytic leukemia |
| title_fullStr | Emergence of IGH::CCND1 rearrangement and mutations in TP53, BTK, and BCL2 associated with therapy resistance in chronic lymphocytic leukemia |
| title_full_unstemmed | Emergence of IGH::CCND1 rearrangement and mutations in TP53, BTK, and BCL2 associated with therapy resistance in chronic lymphocytic leukemia |
| title_short | Emergence of IGH::CCND1 rearrangement and mutations in TP53, BTK, and BCL2 associated with therapy resistance in chronic lymphocytic leukemia |
| title_sort | emergence of igh ccnd1 rearrangement and mutations in tp53 btk and bcl2 associated with therapy resistance in chronic lymphocytic leukemia |
| topic | CLL IGH:CCND1 rearrangement mutations therapy‐resistance |
| url | https://doi.org/10.1002/jha2.1024 |
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