SIDE EFFECTS OF SECOND-LINE ANTITUBERCULOSIS DRUGS IN MULTI-DRUG RESISTANCE (MDR) TUBERCULOSIS PATIENTS
Multidrug-resistant tuberculosis (MDR TB) is caused by Mycobacterium tuberculosis strains resistant to isoniazid and rifampicin—the most potent anti-TB drugs. Prolonged treatment duration and complex drug regimens often lead to poor adherence, contributing to high MDR TB incidence and low treatment...
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| Language: | Indonesian |
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Universitas Sriwijaya
2025-04-01
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| Series: | Jurnal Kedokteran dan Kesehatan |
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| Online Access: | https://jkk-fk.ejournal.unsri.ac.id/index.php/jkk/article/view/483 |
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| author | Nia Savitri Tamzil Geofanny Lorenza R.A. Linda Andriani Theodorus Theodorus Sudarto Sudarto Evi Lusiana Debby Handayati Harahap Desi Oktariana Gita Dwi Prasasty |
| author_facet | Nia Savitri Tamzil Geofanny Lorenza R.A. Linda Andriani Theodorus Theodorus Sudarto Sudarto Evi Lusiana Debby Handayati Harahap Desi Oktariana Gita Dwi Prasasty |
| author_sort | Nia Savitri Tamzil |
| collection | DOAJ |
| description | Multidrug-resistant tuberculosis (MDR TB) is caused by Mycobacterium tuberculosis strains resistant to isoniazid and rifampicin—the most potent anti-TB drugs. Prolonged treatment duration and complex drug regimens often lead to poor adherence, contributing to high MDR TB incidence and low treatment success rates, particularly in Indonesia. This study analyzed drug utilization patterns in 52 MDR TB patients at Dr. Mohammad Hoesin Hospital Palembang, using total sampling based on medical records from October 2018 to December 2019. Data were analyzed descriptively with SPSS v25. The most common side effects reported were weakness, nausea, and vomiting (84.6%), followed by arthralgia, hyperuricemia, and hearing loss (42.3%). Severe side effects were more prevalent in the short-term regimen group (40.4%) compared to the long-term group (7.7%). Weakness, nausea, and vomiting were the most frequently observed side effects in MDR TB patients. |
| format | Article |
| id | doaj-art-82bd684cd2624721bb061ff16ea98617 |
| institution | OA Journals |
| issn | 2406-7431 2614-0411 |
| language | Indonesian |
| publishDate | 2025-04-01 |
| publisher | Universitas Sriwijaya |
| record_format | Article |
| series | Jurnal Kedokteran dan Kesehatan |
| spelling | doaj-art-82bd684cd2624721bb061ff16ea986172025-08-20T02:03:00ZindUniversitas SriwijayaJurnal Kedokteran dan Kesehatan2406-74312614-04112025-04-0112216116910.32539/jkk.v12i2.483484SIDE EFFECTS OF SECOND-LINE ANTITUBERCULOSIS DRUGS IN MULTI-DRUG RESISTANCE (MDR) TUBERCULOSIS PATIENTSNia Savitri Tamzil0Geofanny Lorenza1R.A. Linda Andriani2Theodorus Theodorus3Sudarto Sudarto4Evi Lusiana5Debby Handayati Harahap6Desi Oktariana7Gita Dwi Prasasty8Pharmacology Department, Medical Faculty, Universitas Sriwijaya, Palembang, IndonesiaMedical Education Study Program, Medical Faculty, Universitas Sriwijaya, Palembang, IndonesiaInternal Medicine Department, Medical Faculty, Universitas Sriwijaya, Palembang, IndonesiaPharmacology Department, Medical Faculty, Universitas Sriwijaya, Palembang, IndonesiaInternal Medicine Department, Medical Faculty, Universitas Sriwijaya, Palembang, IndonesiaPharmacology Department, Medical Faculty, Universitas Sriwijaya, Palembang, IndonesiaPharmacology Department, Medical Faculty, Universitas Sriwijaya, Palembang, IndonesiaClinical Pathology Department, Medical Faculty, Universitas Sriwijaya, Palembang, IndonesiaParasitology Department, Medical Faculty, Universitas Sriwijaya, Palembang, IndonesiaMultidrug-resistant tuberculosis (MDR TB) is caused by Mycobacterium tuberculosis strains resistant to isoniazid and rifampicin—the most potent anti-TB drugs. Prolonged treatment duration and complex drug regimens often lead to poor adherence, contributing to high MDR TB incidence and low treatment success rates, particularly in Indonesia. This study analyzed drug utilization patterns in 52 MDR TB patients at Dr. Mohammad Hoesin Hospital Palembang, using total sampling based on medical records from October 2018 to December 2019. Data were analyzed descriptively with SPSS v25. The most common side effects reported were weakness, nausea, and vomiting (84.6%), followed by arthralgia, hyperuricemia, and hearing loss (42.3%). Severe side effects were more prevalent in the short-term regimen group (40.4%) compared to the long-term group (7.7%). Weakness, nausea, and vomiting were the most frequently observed side effects in MDR TB patients.https://jkk-fk.ejournal.unsri.ac.id/index.php/jkk/article/view/483mdr-tb anti-tuberculosis drug side effect |
| spellingShingle | Nia Savitri Tamzil Geofanny Lorenza R.A. Linda Andriani Theodorus Theodorus Sudarto Sudarto Evi Lusiana Debby Handayati Harahap Desi Oktariana Gita Dwi Prasasty SIDE EFFECTS OF SECOND-LINE ANTITUBERCULOSIS DRUGS IN MULTI-DRUG RESISTANCE (MDR) TUBERCULOSIS PATIENTS Jurnal Kedokteran dan Kesehatan mdr-tb anti-tuberculosis drug side effect |
| title | SIDE EFFECTS OF SECOND-LINE ANTITUBERCULOSIS DRUGS IN MULTI-DRUG RESISTANCE (MDR) TUBERCULOSIS PATIENTS |
| title_full | SIDE EFFECTS OF SECOND-LINE ANTITUBERCULOSIS DRUGS IN MULTI-DRUG RESISTANCE (MDR) TUBERCULOSIS PATIENTS |
| title_fullStr | SIDE EFFECTS OF SECOND-LINE ANTITUBERCULOSIS DRUGS IN MULTI-DRUG RESISTANCE (MDR) TUBERCULOSIS PATIENTS |
| title_full_unstemmed | SIDE EFFECTS OF SECOND-LINE ANTITUBERCULOSIS DRUGS IN MULTI-DRUG RESISTANCE (MDR) TUBERCULOSIS PATIENTS |
| title_short | SIDE EFFECTS OF SECOND-LINE ANTITUBERCULOSIS DRUGS IN MULTI-DRUG RESISTANCE (MDR) TUBERCULOSIS PATIENTS |
| title_sort | side effects of second line antituberculosis drugs in multi drug resistance mdr tuberculosis patients |
| topic | mdr-tb anti-tuberculosis drug side effect |
| url | https://jkk-fk.ejournal.unsri.ac.id/index.php/jkk/article/view/483 |
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