Phage-Based Artificial Niche: The Recent Progress and Future Opportunities in Stem Cell Therapy
Self-renewal and differentiation of stem cells can be the best option for treating intractable diseases in regenerative medicine, and they occur when these cells reside in a special microenvironment, called the “stem cell niche.” Thus, the niche is crucial for the effective performance of the stem c...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2019/4038560 |
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| _version_ | 1850214947361914880 |
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| author | Kshitiz Raj Shrestha So Young Yoo |
| author_facet | Kshitiz Raj Shrestha So Young Yoo |
| author_sort | Kshitiz Raj Shrestha |
| collection | DOAJ |
| description | Self-renewal and differentiation of stem cells can be the best option for treating intractable diseases in regenerative medicine, and they occur when these cells reside in a special microenvironment, called the “stem cell niche.” Thus, the niche is crucial for the effective performance of the stem cells in both in vivo and in vitro since the niche provides its functional cues by interacting with stem cells chemically, physically, or topologically. This review provides a perspective on the different types of artificial niches including engineered phage and how they could be used to recapitulate or manipulate stem cell niches. Phage-based artificial niche engineering as a promising therapeutic strategy for repair and regeneration of tissues is also discussed. |
| format | Article |
| id | doaj-art-82bcbdd1c8814e5dbf2d809fab9ed297 |
| institution | OA Journals |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-82bcbdd1c8814e5dbf2d809fab9ed2972025-08-20T02:08:46ZengWileyStem Cells International1687-966X1687-96782019-01-01201910.1155/2019/40385604038560Phage-Based Artificial Niche: The Recent Progress and Future Opportunities in Stem Cell TherapyKshitiz Raj Shrestha0So Young Yoo1BIO-IT Foundry Technology Institute, Pusan National University, Busan 46241, Republic of KoreaBIO-IT Foundry Technology Institute, Pusan National University, Busan 46241, Republic of KoreaSelf-renewal and differentiation of stem cells can be the best option for treating intractable diseases in regenerative medicine, and they occur when these cells reside in a special microenvironment, called the “stem cell niche.” Thus, the niche is crucial for the effective performance of the stem cells in both in vivo and in vitro since the niche provides its functional cues by interacting with stem cells chemically, physically, or topologically. This review provides a perspective on the different types of artificial niches including engineered phage and how they could be used to recapitulate or manipulate stem cell niches. Phage-based artificial niche engineering as a promising therapeutic strategy for repair and regeneration of tissues is also discussed.http://dx.doi.org/10.1155/2019/4038560 |
| spellingShingle | Kshitiz Raj Shrestha So Young Yoo Phage-Based Artificial Niche: The Recent Progress and Future Opportunities in Stem Cell Therapy Stem Cells International |
| title | Phage-Based Artificial Niche: The Recent Progress and Future Opportunities in Stem Cell Therapy |
| title_full | Phage-Based Artificial Niche: The Recent Progress and Future Opportunities in Stem Cell Therapy |
| title_fullStr | Phage-Based Artificial Niche: The Recent Progress and Future Opportunities in Stem Cell Therapy |
| title_full_unstemmed | Phage-Based Artificial Niche: The Recent Progress and Future Opportunities in Stem Cell Therapy |
| title_short | Phage-Based Artificial Niche: The Recent Progress and Future Opportunities in Stem Cell Therapy |
| title_sort | phage based artificial niche the recent progress and future opportunities in stem cell therapy |
| url | http://dx.doi.org/10.1155/2019/4038560 |
| work_keys_str_mv | AT kshitizrajshrestha phagebasedartificialnichetherecentprogressandfutureopportunitiesinstemcelltherapy AT soyoungyoo phagebasedartificialnichetherecentprogressandfutureopportunitiesinstemcelltherapy |