Recombinant Protein Spectral Library (rPSL) DIA-MS method improves identification and quantification of low-abundance cancer-associated and kynurenine pathway proteins

Recombinant Protein Spectral Library (rPSL) DIA-MS method improves identification and quantification of low-abundance cancer-associated and kynurenine pathway proteins

Abstract Data-independent acquisition mass spectrometry (DIA-MS) is a powerful tool for quantitative proteomics, but a well-constructed reference spectral library is crucial to optimize DIA analysis, particularly for low-abundance proteins. In this study, we evaluate the efficacy of a recombinant pr...

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Main Authors: Shivani Krishnamurthy, Bavani Gunasegaran, Moumita Paul-Heng, Abidali Mohamedali, William P. Klare, C. N. Ignatius Pang, Laurence Gluch, Joo-Shik Shin, Charles Chan, Mark S. Baker, Seong Beom Ahn, Benjamin Heng
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-025-01531-0
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