Myeloid EGFR deficiency accelerates recovery from AKI via macrophage efferocytosis and neutrophil apoptosis

Myeloid EGFR deficiency accelerates recovery from AKI via macrophage efferocytosis and neutrophil apoptosis

Abstract Altered expression and activation of Epidermal Growth Factor Receptor (EGFR) is implicated in acute and chronic kidney injury. One of the important cellular sources of EGFR is the myeloid compartment, which plays roles in both acute kidney injury and subsequent fibrosis. Here we show in a m...

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Main Authors: Yu Pan, Shirong Cao, Yinqiu Wang, Jiaqi Tang, Aolei Niu, Sarah Abu Kar, Mengdi Jiang, Fenfen Peng, Gabriela M. Siew, Wentian Lu, Suwan Wang, Matthew Wilson, Craig Brooks, Agnes B. Fogo, Andrew S. Terker, Juan Pablo Arroyo Ornelas, Jianchun Chen, Ming-Zhi Zhang, Raymond C. Harris
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59393-y
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