Molecular simulations reveal intricate coupling between agonist-bound β-adrenergic receptors and G protein

Molecular simulations reveal intricate coupling between agonist-bound β-adrenergic receptors and G protein

Summary: G protein-coupled receptors (GPCRs) and G proteins transmit signals from hormones and neurotransmitters across cell membranes, initiating downstream signaling and modulating cellular behavior. Using advanced computer modeling and simulation, we identified atomistic-level structural, dynamic...

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Main Authors: Yanxiao Han, John R.D. Dawson, Kevin R. DeMarco, Kyle C. Rouen, Khoa Ngo, Slava Bekker, Vladimir Yarov-Yarovoy, Colleen E. Clancy, Yang K. Xiang, Surl-Hee Ahn, Igor Vorobyov
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:iScience
Subjects:
Protein structure aspects
Computational bioinformatics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224029687
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http://www.sciencedirect.com/science/article/pii/S2589004224029687

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