Increased bronchiectasis risk and related risk factors in inflammatory bowel disease: a 10-year Korean national cohort study
Background The association between inflammatory bowel disease (IBD) and an increased risk of bronchiectasis, as well as contributing factors, remains unclear. Additionally, whether bronchiectasis increases disease burden in IBD remains unknown. Therefore, this study aimed to: 1) assess whether IBD i...
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| Format: | Article |
| Language: | English |
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European Respiratory Society
2024-07-01
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| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/10/4/00087-2024.full |
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| author | Jun Su Lee Bumhee Yang Hye Soon Shin Heajung Lee Hyun Gyung Chai Hayoung Choi Joung-Ho Han Jai Hoon Yoon Eung-Gook Kim Hyun Lee |
| author_facet | Jun Su Lee Bumhee Yang Hye Soon Shin Heajung Lee Hyun Gyung Chai Hayoung Choi Joung-Ho Han Jai Hoon Yoon Eung-Gook Kim Hyun Lee |
| author_sort | Jun Su Lee |
| collection | DOAJ |
| description | Background
The association between inflammatory bowel disease (IBD) and an increased risk of bronchiectasis, as well as contributing factors, remains unclear. Additionally, whether bronchiectasis increases disease burden in IBD remains unknown. Therefore, this study aimed to: 1) assess whether IBD increases the risk of incident bronchiectasis; 2) compare the risk of bronchiectasis between individuals with Crohn's disease (CD) and those with ulcerative colitis (UC); 3) identify risk factors for bronchiectasis in individuals with IBD; and 4) examine the disease burden in individuals with IBD and bronchiectasis versus those without.
Methods
We conducted a population-based matched cohort study involving adults aged ≥20 years with IBD, using data acquired from the Korean National Health Insurance Service-National Sample Cohort database between 2002 and 2012.
Results
During the mean follow-up of 9.6 years, the incidence rate of bronchiectasis was 419.63 out of 100 000 person-years (PY) and 309.65 out of 100 000 PY in the IBD and matched cohorts (adjusted hazard ratio (aHR) 1.21, 95% CI 1.05–1.39), respectively. UC was associated with increased bronchiectasis risk (aHR 1.42, 95% CI 1.19–1.69), but CD was not. Multivariate Cox regression analyses showed that age, male sex, medical aid, underweight status, COPD and diabetes mellitus were associated with an increased risk of bronchiectasis in the IBD cohort (p<0.05). The mortality, emergency department visit and hospitalisation rates were significantly higher for individuals with IBD and bronchiectasis compared with those without bronchiectasis (p<0.05).
Conclusion
IBD is associated with increased risk of bronchiectasis, which results in a greater disease burden in individuals with IBD. |
| format | Article |
| id | doaj-art-829d7de5e22d47fca65988fb4e2d70d0 |
| institution | OA Journals |
| issn | 2312-0541 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj-art-829d7de5e22d47fca65988fb4e2d70d02025-08-20T01:54:25ZengEuropean Respiratory SocietyERJ Open Research2312-05412024-07-0110410.1183/23120541.00087-202400087-2024Increased bronchiectasis risk and related risk factors in inflammatory bowel disease: a 10-year Korean national cohort studyJun Su Lee0Bumhee Yang1Hye Soon Shin2Heajung Lee3Hyun Gyung Chai4Hayoung Choi5Joung-Ho Han6Jai Hoon Yoon7Eung-Gook Kim8Hyun Lee9 Division of Gastroenterology, Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Republic of Korea Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Republic of Korea Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Republic of Korea Department of Statistics and Data Science, Yonsei University, Seoul, Republic of Korea MEDICRO, Gyeonggi-do, Republic of Korea Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea Division of Gastroenterology, Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Republic of Korea Division of Gastroenterology and Hepatology, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea Division of Biochemistry, College of Medicine, Chungbuk National University, Cheongju, Republic of Korea Division of Pulmonary Medicine and Allergy, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea Background The association between inflammatory bowel disease (IBD) and an increased risk of bronchiectasis, as well as contributing factors, remains unclear. Additionally, whether bronchiectasis increases disease burden in IBD remains unknown. Therefore, this study aimed to: 1) assess whether IBD increases the risk of incident bronchiectasis; 2) compare the risk of bronchiectasis between individuals with Crohn's disease (CD) and those with ulcerative colitis (UC); 3) identify risk factors for bronchiectasis in individuals with IBD; and 4) examine the disease burden in individuals with IBD and bronchiectasis versus those without. Methods We conducted a population-based matched cohort study involving adults aged ≥20 years with IBD, using data acquired from the Korean National Health Insurance Service-National Sample Cohort database between 2002 and 2012. Results During the mean follow-up of 9.6 years, the incidence rate of bronchiectasis was 419.63 out of 100 000 person-years (PY) and 309.65 out of 100 000 PY in the IBD and matched cohorts (adjusted hazard ratio (aHR) 1.21, 95% CI 1.05–1.39), respectively. UC was associated with increased bronchiectasis risk (aHR 1.42, 95% CI 1.19–1.69), but CD was not. Multivariate Cox regression analyses showed that age, male sex, medical aid, underweight status, COPD and diabetes mellitus were associated with an increased risk of bronchiectasis in the IBD cohort (p<0.05). The mortality, emergency department visit and hospitalisation rates were significantly higher for individuals with IBD and bronchiectasis compared with those without bronchiectasis (p<0.05). Conclusion IBD is associated with increased risk of bronchiectasis, which results in a greater disease burden in individuals with IBD.http://openres.ersjournals.com/content/10/4/00087-2024.full |
| spellingShingle | Jun Su Lee Bumhee Yang Hye Soon Shin Heajung Lee Hyun Gyung Chai Hayoung Choi Joung-Ho Han Jai Hoon Yoon Eung-Gook Kim Hyun Lee Increased bronchiectasis risk and related risk factors in inflammatory bowel disease: a 10-year Korean national cohort study ERJ Open Research |
| title | Increased bronchiectasis risk and related risk factors in inflammatory bowel disease: a 10-year Korean national cohort study |
| title_full | Increased bronchiectasis risk and related risk factors in inflammatory bowel disease: a 10-year Korean national cohort study |
| title_fullStr | Increased bronchiectasis risk and related risk factors in inflammatory bowel disease: a 10-year Korean national cohort study |
| title_full_unstemmed | Increased bronchiectasis risk and related risk factors in inflammatory bowel disease: a 10-year Korean national cohort study |
| title_short | Increased bronchiectasis risk and related risk factors in inflammatory bowel disease: a 10-year Korean national cohort study |
| title_sort | increased bronchiectasis risk and related risk factors in inflammatory bowel disease a 10 year korean national cohort study |
| url | http://openres.ersjournals.com/content/10/4/00087-2024.full |
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