Resting-State Network Plasticity Induced by Music Therapy after Traumatic Brain Injury
Traumatic brain injury (TBI) is characterized by a complex pattern of abnormalities in resting-state functional connectivity (rsFC) and network dysfunction, which can potentially be ameliorated by rehabilitation. In our previous randomized controlled trial, we found that a 3-month neurological music...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2021/6682471 |
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| author | Noelia Martínez-Molina Sini-Tuuli Siponkoski Linda Kuusela Sari Laitinen Milla Holma Mirja Ahlfors Päivi Jordan-Kilkki Katja Ala-Kauhaluoma Susanna Melkas Johanna Pekkola Antoni Rodríguez-Fornells Matti Laine Aarne Ylinen Pekka Rantanen Sanna Koskinen Benjamin Ultan Cowley Teppo Särkämö |
| author_facet | Noelia Martínez-Molina Sini-Tuuli Siponkoski Linda Kuusela Sari Laitinen Milla Holma Mirja Ahlfors Päivi Jordan-Kilkki Katja Ala-Kauhaluoma Susanna Melkas Johanna Pekkola Antoni Rodríguez-Fornells Matti Laine Aarne Ylinen Pekka Rantanen Sanna Koskinen Benjamin Ultan Cowley Teppo Särkämö |
| author_sort | Noelia Martínez-Molina |
| collection | DOAJ |
| description | Traumatic brain injury (TBI) is characterized by a complex pattern of abnormalities in resting-state functional connectivity (rsFC) and network dysfunction, which can potentially be ameliorated by rehabilitation. In our previous randomized controlled trial, we found that a 3-month neurological music therapy intervention enhanced executive function (EF) and increased grey matter volume in the right inferior frontal gyrus (IFG) in patients with moderate-to-severe TBI (N=40). Extending this study, we performed longitudinal rsFC analyses of resting-state fMRI data using a ROI-to-ROI approach assessing within-network and between-network rsFC in the frontoparietal (FPN), dorsal attention (DAN), default mode (DMN), and salience (SAL) networks, which all have been associated with cognitive impairment after TBI. We also performed a seed-based connectivity analysis between the right IFG and whole-brain rsFC. The results showed that neurological music therapy increased the coupling between the FPN and DAN as well as between these networks and primary sensory networks. By contrast, the DMN was less connected with sensory networks after the intervention. Similarly, there was a shift towards a less connected state within the FPN and SAL networks, which are typically hyperconnected following TBI. Improvements in EF were correlated with rsFC within the FPN and between the DMN and sensorimotor networks. Finally, in the seed-based connectivity analysis, the right IFG showed increased rsFC with the right inferior parietal and left frontoparietal (Rolandic operculum) regions. Together, these results indicate that the rehabilitative effects of neurological music therapy after TBI are underpinned by a pattern of within- and between-network connectivity changes in cognitive networks as well as increased connectivity between frontal and parietal regions associated with music processing. |
| format | Article |
| id | doaj-art-8296416098064a7fb8fc9b285a812aea |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-8296416098064a7fb8fc9b285a812aea2025-08-20T03:35:50ZengWileyNeural Plasticity2090-59041687-54432021-01-01202110.1155/2021/66824716682471Resting-State Network Plasticity Induced by Music Therapy after Traumatic Brain InjuryNoelia Martínez-Molina0Sini-Tuuli Siponkoski1Linda Kuusela2Sari Laitinen3Milla Holma4Mirja Ahlfors5Päivi Jordan-Kilkki6Katja Ala-Kauhaluoma7Susanna Melkas8Johanna Pekkola9Antoni Rodríguez-Fornells10Matti Laine11Aarne Ylinen12Pekka Rantanen13Sanna Koskinen14Benjamin Ultan Cowley15Teppo Särkämö16Music, Ageing and Rehabilitation Team, Cognitive Brain Research Unit, Department of Psychology and Logopedics, University of Helsinki, Helsinki, FinlandMusic, Ageing and Rehabilitation Team, Cognitive Brain Research Unit, Department of Psychology and Logopedics, University of Helsinki, Helsinki, FinlandDepartment of Physics, University of Helsinki, Helsinki, FinlandEspoo Hospital, Espoo, FinlandMusic Therapy Cooperative Instrumental, Helsinki, FinlandPrivate Music Therapy, Espoo, FinlandDialogic Partner Oy, Espoo, FinlandLudus Assessment and Intervention Services, Helsinki, FinlandDepartment of Neurology, University of Helsinki and Helsinki University Hospital, Helsinki, FinlandHUS Medical Imaging Center, Department of Radiology, Helsinki Central University Hospital and University of Helsinki, Helsinki, FinlandCognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute, L’Hospitalet de Llobregat, Barcelona, SpainDepartment of Psychology, Åbo Akademi University, Turku, FinlandDepartment of Neurology, University of Helsinki and Helsinki University Hospital, Helsinki, FinlandDepartment of Physical and Rehabilitation Medicine, Helsinki University Hospital, Helsinki, FinlandDepartment of Psychology and Logopedics, University of Helsinki, Helsinki, FinlandFaculty of Educational Sciences, University of Helsinki, Helsinki, FinlandMusic, Ageing and Rehabilitation Team, Cognitive Brain Research Unit, Department of Psychology and Logopedics, University of Helsinki, Helsinki, FinlandTraumatic brain injury (TBI) is characterized by a complex pattern of abnormalities in resting-state functional connectivity (rsFC) and network dysfunction, which can potentially be ameliorated by rehabilitation. In our previous randomized controlled trial, we found that a 3-month neurological music therapy intervention enhanced executive function (EF) and increased grey matter volume in the right inferior frontal gyrus (IFG) in patients with moderate-to-severe TBI (N=40). Extending this study, we performed longitudinal rsFC analyses of resting-state fMRI data using a ROI-to-ROI approach assessing within-network and between-network rsFC in the frontoparietal (FPN), dorsal attention (DAN), default mode (DMN), and salience (SAL) networks, which all have been associated with cognitive impairment after TBI. We also performed a seed-based connectivity analysis between the right IFG and whole-brain rsFC. The results showed that neurological music therapy increased the coupling between the FPN and DAN as well as between these networks and primary sensory networks. By contrast, the DMN was less connected with sensory networks after the intervention. Similarly, there was a shift towards a less connected state within the FPN and SAL networks, which are typically hyperconnected following TBI. Improvements in EF were correlated with rsFC within the FPN and between the DMN and sensorimotor networks. Finally, in the seed-based connectivity analysis, the right IFG showed increased rsFC with the right inferior parietal and left frontoparietal (Rolandic operculum) regions. Together, these results indicate that the rehabilitative effects of neurological music therapy after TBI are underpinned by a pattern of within- and between-network connectivity changes in cognitive networks as well as increased connectivity between frontal and parietal regions associated with music processing.http://dx.doi.org/10.1155/2021/6682471 |
| spellingShingle | Noelia Martínez-Molina Sini-Tuuli Siponkoski Linda Kuusela Sari Laitinen Milla Holma Mirja Ahlfors Päivi Jordan-Kilkki Katja Ala-Kauhaluoma Susanna Melkas Johanna Pekkola Antoni Rodríguez-Fornells Matti Laine Aarne Ylinen Pekka Rantanen Sanna Koskinen Benjamin Ultan Cowley Teppo Särkämö Resting-State Network Plasticity Induced by Music Therapy after Traumatic Brain Injury Neural Plasticity |
| title | Resting-State Network Plasticity Induced by Music Therapy after Traumatic Brain Injury |
| title_full | Resting-State Network Plasticity Induced by Music Therapy after Traumatic Brain Injury |
| title_fullStr | Resting-State Network Plasticity Induced by Music Therapy after Traumatic Brain Injury |
| title_full_unstemmed | Resting-State Network Plasticity Induced by Music Therapy after Traumatic Brain Injury |
| title_short | Resting-State Network Plasticity Induced by Music Therapy after Traumatic Brain Injury |
| title_sort | resting state network plasticity induced by music therapy after traumatic brain injury |
| url | http://dx.doi.org/10.1155/2021/6682471 |
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