Muscular Dystrophy-Dystroglycanopathy and Epilepsy

Investigators from the University of Catania, and other centers in Europe have identified a novel genetic glycosylation disorder, DPM2-CDG (part of the DPM synthase complex) in 3 infants with severe hypotonia, progressive muscle weakness and wasting, elevated CK, absent psychomotor development, intr...

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Main Author: J Gordon Millichap
Format: Article
Language:English
Published: Pediatric Neurology Briefs Publishers 2013-01-01
Series:Pediatric Neurology Briefs
Subjects:
Online Access:https://www.pediatricneurologybriefs.com/articles/462
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author J Gordon Millichap
author_facet J Gordon Millichap
author_sort J Gordon Millichap
collection DOAJ
description Investigators from the University of Catania, and other centers in Europe have identified a novel genetic glycosylation disorder, DPM2-CDG (part of the DPM synthase complex) in 3 infants with severe hypotonia, progressive muscle weakness and wasting, elevated CK, absent psychomotor development, intractable epilepsy with onset at 1 week to 5 months, and early mortality.
format Article
id doaj-art-8294411ffc7f4d8dad0045f7de6a3c64
institution OA Journals
issn 1043-3155
2166-6482
language English
publishDate 2013-01-01
publisher Pediatric Neurology Briefs Publishers
record_format Article
series Pediatric Neurology Briefs
spelling doaj-art-8294411ffc7f4d8dad0045f7de6a3c642025-08-20T01:54:53ZengPediatric Neurology Briefs PublishersPediatric Neurology Briefs1043-31552166-64822013-01-012713410.15844/pedneurbriefs-27-1-4448Muscular Dystrophy-Dystroglycanopathy and EpilepsyJ Gordon Millichap0Northwestern University Feinberg School of MedicineInvestigators from the University of Catania, and other centers in Europe have identified a novel genetic glycosylation disorder, DPM2-CDG (part of the DPM synthase complex) in 3 infants with severe hypotonia, progressive muscle weakness and wasting, elevated CK, absent psychomotor development, intractable epilepsy with onset at 1 week to 5 months, and early mortality.https://www.pediatricneurologybriefs.com/articles/462genetic glycosylationhypotoniaearly mortality
spellingShingle J Gordon Millichap
Muscular Dystrophy-Dystroglycanopathy and Epilepsy
Pediatric Neurology Briefs
genetic glycosylation
hypotonia
early mortality
title Muscular Dystrophy-Dystroglycanopathy and Epilepsy
title_full Muscular Dystrophy-Dystroglycanopathy and Epilepsy
title_fullStr Muscular Dystrophy-Dystroglycanopathy and Epilepsy
title_full_unstemmed Muscular Dystrophy-Dystroglycanopathy and Epilepsy
title_short Muscular Dystrophy-Dystroglycanopathy and Epilepsy
title_sort muscular dystrophy dystroglycanopathy and epilepsy
topic genetic glycosylation
hypotonia
early mortality
url https://www.pediatricneurologybriefs.com/articles/462
work_keys_str_mv AT jgordonmillichap musculardystrophydystroglycanopathyandepilepsy