Invasive aspergillosis: results of multicenter study

Invasive aspergillosis: results of multicenter study

We present the results of a multicenter study of 445 patients with “proven” and “probable” invasive aspergillosis (EORTC/MSG, 2008). Invasive aspergillosis usually occurs in patients with hematological malignancies (88 %), main underlying diseases were acute myeloid and acute lymphoblastic leukemia....

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Main Authors: N. N. Klimko, O. V. Shadrivova, S. N. Khostelidi, E. A. Desyatik, Yu. V. Borzova, R. M. Chernopyatova, E. V. Shagdileeva, A. G. Volkova, M. O. Popova, I. S. Zyuzgin, O. S. Ruzhinskaya, O. Ye. Ryabykina, N. V. Medvedeva, A. S. Kolbin, E. G. Boychenko, T. S. Bogomolova, S. M. Ignatieva, L. S. Zubarovskaya, B. V. Afanasiev
Format: Article
Language:Russian
Published: ABV-press 2014-09-01
Series:Онкогематология
Subjects:
aspergillus
invasive aspergillosis
hematological malignancies
voriconazole
Online Access:https://oncohematology.abvpress.ru/ongm/article/view/110
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Summary:We present the results of a multicenter study of 445 patients with “proven” and “probable” invasive aspergillosis (EORTC/MSG, 2008). Invasive aspergillosis usually occurs in patients with hematological malignancies (88 %), main underlying diseases were acute myeloid and acute lymphoblastic leukemia. The risk factors: prolonged agranulocytosis (64 %), cytostatic chemotherapy (57 %), corticosteroid treatment (45 %), and allogeneic hematopoietic stem cells transplantation (29 %). The pathogens – A. fumigatus (42 %), A. niger (33 %), and A. flavus (21 %). The main site of infection were lungs (86 %). 12 week overall survival was 83 %. Bronchoscopy use for the early diagnosis (p = 0.01), adequatetherapy with voriconazole (p = 0.002) and secondary antifungal prophylaxis (p = 0.0003) were positive prognostic factors for survival of patients with invasive aspergillosis.
ISSN:1818-8346
2413-4023

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