Epigenetic Regulation of Inflammatory Cytokines and Associated Genes in Human Malignancies
Inflammation is a multifaceted defense response of immune system against infection. Chronic inflammation has been implicated as an imminent threat for major human malignancies and is directly linked to various steps involved in tumorigenesis. Inflammatory cytokines, interleukins, interferons, transf...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/201703 |
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| _version_ | 1850215784884731904 |
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| author | Rehana Yasmin Sami Siraj Amjad Hassan Abdul Rehman Khan Rashda Abbasi Nafees Ahmad |
| author_facet | Rehana Yasmin Sami Siraj Amjad Hassan Abdul Rehman Khan Rashda Abbasi Nafees Ahmad |
| author_sort | Rehana Yasmin |
| collection | DOAJ |
| description | Inflammation is a multifaceted defense response of immune system against infection. Chronic inflammation has been implicated as an imminent threat for major human malignancies and is directly linked to various steps involved in tumorigenesis. Inflammatory cytokines, interleukins, interferons, transforming growth factors, chemokines, and adhesion molecules have been associated with chronic inflammation. Numerous cytokines are reported to be aberrantly regulated by different epigenetic mechanisms like DNA methylation and histone modifications in tumor tissues, contributing to pathogenesis of tumor in multiple ways. Some of these cytokines also work as epigenetic regulators of other crucial genes in tumor biology, either directly or indirectly. Such regulations are reported in lung, breast, cervical, gastric, colorectal, pancreatic, prostate, and head and neck cancers. Epigenetics of inflammatory mediators in cancer is currently subject of extensive research. These investigations may help in understanding cancer biology and to develop effective therapeutic strategies. The purpose of this paper is to have a brief view of the aberrant regulation of inflammatory cytokines in human malignancies. |
| format | Article |
| id | doaj-art-8286e93f2a9d4dd4820e75b6bcb1bb27 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-8286e93f2a9d4dd4820e75b6bcb1bb272025-08-20T02:08:31ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/201703201703Epigenetic Regulation of Inflammatory Cytokines and Associated Genes in Human MalignanciesRehana Yasmin0Sami Siraj1Amjad Hassan2Abdul Rehman Khan3Rashda Abbasi4Nafees Ahmad5Department of Environmental Sciences, COMSATS Institute of Information Technology, Abbottabad 22060, PakistanInstitute of Basic Medical Sciences, Khyber Medical University, Peshawar 25124, PakistanDepartment of Environmental Sciences, COMSATS Institute of Information Technology, Abbottabad 22060, PakistanDepartment of Environmental Sciences, COMSATS Institute of Information Technology, Abbottabad 22060, PakistanInstitute of Biomedical and Genetic Engineering, Islamabad 54000, PakistanInstitute of Biomedical and Genetic Engineering, Islamabad 54000, PakistanInflammation is a multifaceted defense response of immune system against infection. Chronic inflammation has been implicated as an imminent threat for major human malignancies and is directly linked to various steps involved in tumorigenesis. Inflammatory cytokines, interleukins, interferons, transforming growth factors, chemokines, and adhesion molecules have been associated with chronic inflammation. Numerous cytokines are reported to be aberrantly regulated by different epigenetic mechanisms like DNA methylation and histone modifications in tumor tissues, contributing to pathogenesis of tumor in multiple ways. Some of these cytokines also work as epigenetic regulators of other crucial genes in tumor biology, either directly or indirectly. Such regulations are reported in lung, breast, cervical, gastric, colorectal, pancreatic, prostate, and head and neck cancers. Epigenetics of inflammatory mediators in cancer is currently subject of extensive research. These investigations may help in understanding cancer biology and to develop effective therapeutic strategies. The purpose of this paper is to have a brief view of the aberrant regulation of inflammatory cytokines in human malignancies.http://dx.doi.org/10.1155/2015/201703 |
| spellingShingle | Rehana Yasmin Sami Siraj Amjad Hassan Abdul Rehman Khan Rashda Abbasi Nafees Ahmad Epigenetic Regulation of Inflammatory Cytokines and Associated Genes in Human Malignancies Mediators of Inflammation |
| title | Epigenetic Regulation of Inflammatory Cytokines and Associated Genes in Human Malignancies |
| title_full | Epigenetic Regulation of Inflammatory Cytokines and Associated Genes in Human Malignancies |
| title_fullStr | Epigenetic Regulation of Inflammatory Cytokines and Associated Genes in Human Malignancies |
| title_full_unstemmed | Epigenetic Regulation of Inflammatory Cytokines and Associated Genes in Human Malignancies |
| title_short | Epigenetic Regulation of Inflammatory Cytokines and Associated Genes in Human Malignancies |
| title_sort | epigenetic regulation of inflammatory cytokines and associated genes in human malignancies |
| url | http://dx.doi.org/10.1155/2015/201703 |
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