IGF2BP2 binding to CPSF6 facilitates m6A‐mediated alternative polyadenylation of PUM2 and promotes malignant progression in ovarian cancer

IGF2BP2 binding to CPSF6 facilitates m6A‐mediated alternative polyadenylation of PUM2 and promotes malignant progression in ovarian cancer

Abstract Background N6‐methyladenosine (m6A) and alternative polyadenylation (APA) are common posttranscriptional regulatory mechanisms in eukaryotes. However, the m6A‐dependent mechanism of APA regulation in ovarian cancer (OC) is still unclear. Methods The correlation between m6A and APA was analy...

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Main Authors: Xin Luo, Qinglv Wei, Lingcui Xie, Ningxuan Chen, Bin Gu, Jiani Xu, Xiaoyan Jiang, Xinzhao Zuo, Hongyan Zhao, Xiaoyi Liu, Yu Yang, Tao Liu, Yong Zhu, Ping Yi, Jing Xu
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Clinical and Translational Medicine
Subjects:
alternative polyadenylation
CPSF6
IGF2BP2
N6‐methyladenosine
ovarian cancer
PUM2
Online Access:https://doi.org/10.1002/ctm2.70388
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