A Methodological Approach to Measuring the Impact of TAK-003 for the Prevention of Dengue in Dourados, Brazil: Optimizing Strategies for Public Health
<b>Background/Objectives</b>: Takeda’s tetravalent dengue vaccine TAK-003 has been approved by the Brazilian regulatory agency ANVISA for dengue disease prevention in individuals aged 4 to 60 years. Dourados, in the state of Mato Grosso do Sul, became the world’s first city to implement...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/13/2/121 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849720082246139904 |
|---|---|
| author | Benedetta Ghezzi Cristina Valencia Roberto Dias de Oliveira Daniel Tsuha Waldno Lucena Júnior Alberta Di Pasquale Morgan Mc Namara Juliana Senra Denise Abud Julio Croda |
| author_facet | Benedetta Ghezzi Cristina Valencia Roberto Dias de Oliveira Daniel Tsuha Waldno Lucena Júnior Alberta Di Pasquale Morgan Mc Namara Juliana Senra Denise Abud Julio Croda |
| author_sort | Benedetta Ghezzi |
| collection | DOAJ |
| description | <b>Background/Objectives</b>: Takeda’s tetravalent dengue vaccine TAK-003 has been approved by the Brazilian regulatory agency ANVISA for dengue disease prevention in individuals aged 4 to 60 years. Dourados, in the state of Mato Grosso do Sul, became the world’s first city to implement a mass vaccination campaign targeting approximately 120,000 individuals. An ongoing collaborative, observational, population-based study using national surveillance and vaccination data was planned to measure the impact of the vaccine on the reduction in dengue incidence. <b>Methods</b>: In this manuscript, the study’s methodology, including its programmatic steps and public health relevance, is described. A collaborative assessment with multidisciplinary researchers in Brazil was conducted to identify key programmatic areas for the successful implementation of the study. These areas included feasibility and site selection assessment, methodology selection, vaccination program implementation, and public health importance. <b>Results/Conclusions</b>: Identification of the public health problem and understanding the disease burden, local healthcare infrastructure, and strategic partnerships were critical for a robust feasibility assessment. One of the feasibility criteria identified was the ability of the Dourados Municipal Health Secretary and the principal investigator to conduct an active vaccination campaign, utilizing extramural activities and diverse communication channels to increase vaccine acceptance and coverage. The selection of analytical methods, such as time series analysis, was dependent on the national and local structures of the databases and data availability. |
| format | Article |
| id | doaj-art-82801002bdf74dfba2e8adb4a156d2a8 |
| institution | DOAJ |
| issn | 2076-393X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj-art-82801002bdf74dfba2e8adb4a156d2a82025-08-20T03:12:01ZengMDPI AGVaccines2076-393X2025-01-0113212110.3390/vaccines13020121A Methodological Approach to Measuring the Impact of TAK-003 for the Prevention of Dengue in Dourados, Brazil: Optimizing Strategies for Public HealthBenedetta Ghezzi0Cristina Valencia1Roberto Dias de Oliveira2Daniel Tsuha3Waldno Lucena Júnior4Alberta Di Pasquale5Morgan Mc Namara6Juliana Senra7Denise Abud8Julio Croda9Takeda Pharmaceuticals International AG, 8152 Zürich, SwitzerlandTakeda Pharmaceuticals International AG, 8152 Zürich, SwitzerlandOswaldo Cruz Foundation, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, BrazilOswaldo Cruz Foundation, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, BrazilMunicipal Health Department of Dourados, Municipal Prefecture of Dourados, Dourados 76051-053, MS, BrazilTakeda Pharmaceuticals International AG, Singapore 018981, SingaporeTakeda Pharmaceuticals International AG, 8152 Zürich, SwitzerlandTakeda Pharmaceuticals International AG, São Paulo 04794-000, SP, BrazilTakeda Pharmaceuticals International AG, Singapore 018981, SingaporeOswaldo Cruz Foundation, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil<b>Background/Objectives</b>: Takeda’s tetravalent dengue vaccine TAK-003 has been approved by the Brazilian regulatory agency ANVISA for dengue disease prevention in individuals aged 4 to 60 years. Dourados, in the state of Mato Grosso do Sul, became the world’s first city to implement a mass vaccination campaign targeting approximately 120,000 individuals. An ongoing collaborative, observational, population-based study using national surveillance and vaccination data was planned to measure the impact of the vaccine on the reduction in dengue incidence. <b>Methods</b>: In this manuscript, the study’s methodology, including its programmatic steps and public health relevance, is described. A collaborative assessment with multidisciplinary researchers in Brazil was conducted to identify key programmatic areas for the successful implementation of the study. These areas included feasibility and site selection assessment, methodology selection, vaccination program implementation, and public health importance. <b>Results/Conclusions</b>: Identification of the public health problem and understanding the disease burden, local healthcare infrastructure, and strategic partnerships were critical for a robust feasibility assessment. One of the feasibility criteria identified was the ability of the Dourados Municipal Health Secretary and the principal investigator to conduct an active vaccination campaign, utilizing extramural activities and diverse communication channels to increase vaccine acceptance and coverage. The selection of analytical methods, such as time series analysis, was dependent on the national and local structures of the databases and data availability.https://www.mdpi.com/2076-393X/13/2/121denguevaccinationpublic healthmethodologyTAK-003 |
| spellingShingle | Benedetta Ghezzi Cristina Valencia Roberto Dias de Oliveira Daniel Tsuha Waldno Lucena Júnior Alberta Di Pasquale Morgan Mc Namara Juliana Senra Denise Abud Julio Croda A Methodological Approach to Measuring the Impact of TAK-003 for the Prevention of Dengue in Dourados, Brazil: Optimizing Strategies for Public Health Vaccines dengue vaccination public health methodology TAK-003 |
| title | A Methodological Approach to Measuring the Impact of TAK-003 for the Prevention of Dengue in Dourados, Brazil: Optimizing Strategies for Public Health |
| title_full | A Methodological Approach to Measuring the Impact of TAK-003 for the Prevention of Dengue in Dourados, Brazil: Optimizing Strategies for Public Health |
| title_fullStr | A Methodological Approach to Measuring the Impact of TAK-003 for the Prevention of Dengue in Dourados, Brazil: Optimizing Strategies for Public Health |
| title_full_unstemmed | A Methodological Approach to Measuring the Impact of TAK-003 for the Prevention of Dengue in Dourados, Brazil: Optimizing Strategies for Public Health |
| title_short | A Methodological Approach to Measuring the Impact of TAK-003 for the Prevention of Dengue in Dourados, Brazil: Optimizing Strategies for Public Health |
| title_sort | methodological approach to measuring the impact of tak 003 for the prevention of dengue in dourados brazil optimizing strategies for public health |
| topic | dengue vaccination public health methodology TAK-003 |
| url | https://www.mdpi.com/2076-393X/13/2/121 |
| work_keys_str_mv | AT benedettaghezzi amethodologicalapproachtomeasuringtheimpactoftak003forthepreventionofdengueindouradosbraziloptimizingstrategiesforpublichealth AT cristinavalencia amethodologicalapproachtomeasuringtheimpactoftak003forthepreventionofdengueindouradosbraziloptimizingstrategiesforpublichealth AT robertodiasdeoliveira amethodologicalapproachtomeasuringtheimpactoftak003forthepreventionofdengueindouradosbraziloptimizingstrategiesforpublichealth AT danieltsuha amethodologicalapproachtomeasuringtheimpactoftak003forthepreventionofdengueindouradosbraziloptimizingstrategiesforpublichealth AT waldnolucenajunior amethodologicalapproachtomeasuringtheimpactoftak003forthepreventionofdengueindouradosbraziloptimizingstrategiesforpublichealth AT albertadipasquale amethodologicalapproachtomeasuringtheimpactoftak003forthepreventionofdengueindouradosbraziloptimizingstrategiesforpublichealth AT morganmcnamara amethodologicalapproachtomeasuringtheimpactoftak003forthepreventionofdengueindouradosbraziloptimizingstrategiesforpublichealth AT julianasenra amethodologicalapproachtomeasuringtheimpactoftak003forthepreventionofdengueindouradosbraziloptimizingstrategiesforpublichealth AT deniseabud amethodologicalapproachtomeasuringtheimpactoftak003forthepreventionofdengueindouradosbraziloptimizingstrategiesforpublichealth AT juliocroda amethodologicalapproachtomeasuringtheimpactoftak003forthepreventionofdengueindouradosbraziloptimizingstrategiesforpublichealth AT benedettaghezzi methodologicalapproachtomeasuringtheimpactoftak003forthepreventionofdengueindouradosbraziloptimizingstrategiesforpublichealth AT cristinavalencia methodologicalapproachtomeasuringtheimpactoftak003forthepreventionofdengueindouradosbraziloptimizingstrategiesforpublichealth AT robertodiasdeoliveira methodologicalapproachtomeasuringtheimpactoftak003forthepreventionofdengueindouradosbraziloptimizingstrategiesforpublichealth AT danieltsuha methodologicalapproachtomeasuringtheimpactoftak003forthepreventionofdengueindouradosbraziloptimizingstrategiesforpublichealth AT waldnolucenajunior methodologicalapproachtomeasuringtheimpactoftak003forthepreventionofdengueindouradosbraziloptimizingstrategiesforpublichealth AT albertadipasquale methodologicalapproachtomeasuringtheimpactoftak003forthepreventionofdengueindouradosbraziloptimizingstrategiesforpublichealth AT morganmcnamara methodologicalapproachtomeasuringtheimpactoftak003forthepreventionofdengueindouradosbraziloptimizingstrategiesforpublichealth AT julianasenra methodologicalapproachtomeasuringtheimpactoftak003forthepreventionofdengueindouradosbraziloptimizingstrategiesforpublichealth AT deniseabud methodologicalapproachtomeasuringtheimpactoftak003forthepreventionofdengueindouradosbraziloptimizingstrategiesforpublichealth AT juliocroda methodologicalapproachtomeasuringtheimpactoftak003forthepreventionofdengueindouradosbraziloptimizingstrategiesforpublichealth |