Prognostic impact of extranodal disease on PET/CT in follicular lymphoma: results from a validation study with ECOG 2408
Abstract: Parameters detected by positron emission tomography (PET) are not included in the usual predictive indices for follicular lymphoma (FL). Data are lacking regarding PET extranodal (EN) factors that predict outcomes in FL. PET scans from 258 patients with untreated grade 1 to 3A FL included...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-08-01
|
| Series: | Blood Neoplasia |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950328025000482 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849303749464424448 |
|---|---|
| author | Frederique St-Pierre Stephen M. Broski Zequn Sun Masha Kocherginsky Betsy LaPlant Matthew J. Maurer Andrew Quon Lucia Baratto Hatice Savas Lale Kostakoglu Jane N. Winter Thomas E. Witzig Brad Kahl Andrew M. Evens Leo I. Gordon |
| author_facet | Frederique St-Pierre Stephen M. Broski Zequn Sun Masha Kocherginsky Betsy LaPlant Matthew J. Maurer Andrew Quon Lucia Baratto Hatice Savas Lale Kostakoglu Jane N. Winter Thomas E. Witzig Brad Kahl Andrew M. Evens Leo I. Gordon |
| author_sort | Frederique St-Pierre |
| collection | DOAJ |
| description | Abstract: Parameters detected by positron emission tomography (PET) are not included in the usual predictive indices for follicular lymphoma (FL). Data are lacking regarding PET extranodal (EN) factors that predict outcomes in FL. PET scans from 258 patients with untreated grade 1 to 3A FL included in the E2408 randomized phase 2 trial were reviewed. Validation of the prognostic significance of PET factors identified in a previous retrospective study was performed. PET factors with a significant impact on survival outcomes were combined with significant FL International Prognostic Index 2 (FLIPI-2) factors to evaluate the predictive value of a PET-based prognostic index. Presence of ≥2 EN sites and skin/soft tissue involvement on PET were validated as predictors of overall survival. These factors were combined with all FLIPI-2 factors except “positive bone marrow biopsy” to form a PET-based prognostic score. This novel score identified a group of patients at high risk of progression of disease at 24 months. This PET-based score did not perform better than the traditional FLIPI-2 on additional analysis. Presence of ≥2 EN sites and skin/soft tissue involvement on PET predict poor outcomes in untreated FL. Further studies should be performed to determine the validity of a PET-based prognostic index in FL. |
| format | Article |
| id | doaj-art-827fb1f3e6884edb9c0109ee88e93fcd |
| institution | Kabale University |
| issn | 2950-3280 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Blood Neoplasia |
| spelling | doaj-art-827fb1f3e6884edb9c0109ee88e93fcd2025-08-20T03:55:59ZengElsevierBlood Neoplasia2950-32802025-08-012310011310.1016/j.bneo.2025.100113Prognostic impact of extranodal disease on PET/CT in follicular lymphoma: results from a validation study with ECOG 2408Frederique St-Pierre0Stephen M. Broski1Zequn Sun2Masha Kocherginsky3Betsy LaPlant4Matthew J. Maurer5Andrew Quon6Lucia Baratto7Hatice Savas8Lale Kostakoglu9Jane N. Winter10Thomas E. Witzig11Brad Kahl12Andrew M. Evens13Leo I. Gordon14Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine and Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, ILDivision of Nuclear Radiology, Department of Radiology, Mayo Clinic, Rochester, MNDivision of Biostatistics, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine and Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, ILDivision of Biostatistics, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine and Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, ILDivision of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MNDivision of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MNDivision of Nuclear Radiology, Department of Radiology, University of California Los Angeles, Los Angeles, CADepartment of Radiology, Stanford University, Stanford, CADivision of Nuclear Medicine, Department of Radiology, Northwestern University Feinberg School of Medicine and Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, ILDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VADivision of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine and Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, ILDivision of Hematology, Department of Medicine, Mayo Clinic, Rochester, MNDivision of Oncology, Department of Medicine, Washington University School of Medicine and Siteman Cancer Center, St Louis, MODivision Blood Disorders, Rutgers Cancer Institute of New Jersey, New Brunswick, NJDivision of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine and Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL; Correspondence: Leo I. Gordon, Division of Hematology/Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, 675 N St Clair St, Suite 85o, Chicago, IL 60611;Abstract: Parameters detected by positron emission tomography (PET) are not included in the usual predictive indices for follicular lymphoma (FL). Data are lacking regarding PET extranodal (EN) factors that predict outcomes in FL. PET scans from 258 patients with untreated grade 1 to 3A FL included in the E2408 randomized phase 2 trial were reviewed. Validation of the prognostic significance of PET factors identified in a previous retrospective study was performed. PET factors with a significant impact on survival outcomes were combined with significant FL International Prognostic Index 2 (FLIPI-2) factors to evaluate the predictive value of a PET-based prognostic index. Presence of ≥2 EN sites and skin/soft tissue involvement on PET were validated as predictors of overall survival. These factors were combined with all FLIPI-2 factors except “positive bone marrow biopsy” to form a PET-based prognostic score. This novel score identified a group of patients at high risk of progression of disease at 24 months. This PET-based score did not perform better than the traditional FLIPI-2 on additional analysis. Presence of ≥2 EN sites and skin/soft tissue involvement on PET predict poor outcomes in untreated FL. Further studies should be performed to determine the validity of a PET-based prognostic index in FL.http://www.sciencedirect.com/science/article/pii/S2950328025000482 |
| spellingShingle | Frederique St-Pierre Stephen M. Broski Zequn Sun Masha Kocherginsky Betsy LaPlant Matthew J. Maurer Andrew Quon Lucia Baratto Hatice Savas Lale Kostakoglu Jane N. Winter Thomas E. Witzig Brad Kahl Andrew M. Evens Leo I. Gordon Prognostic impact of extranodal disease on PET/CT in follicular lymphoma: results from a validation study with ECOG 2408 Blood Neoplasia |
| title | Prognostic impact of extranodal disease on PET/CT in follicular lymphoma: results from a validation study with ECOG 2408 |
| title_full | Prognostic impact of extranodal disease on PET/CT in follicular lymphoma: results from a validation study with ECOG 2408 |
| title_fullStr | Prognostic impact of extranodal disease on PET/CT in follicular lymphoma: results from a validation study with ECOG 2408 |
| title_full_unstemmed | Prognostic impact of extranodal disease on PET/CT in follicular lymphoma: results from a validation study with ECOG 2408 |
| title_short | Prognostic impact of extranodal disease on PET/CT in follicular lymphoma: results from a validation study with ECOG 2408 |
| title_sort | prognostic impact of extranodal disease on pet ct in follicular lymphoma results from a validation study with ecog 2408 |
| url | http://www.sciencedirect.com/science/article/pii/S2950328025000482 |
| work_keys_str_mv | AT frederiquestpierre prognosticimpactofextranodaldiseaseonpetctinfollicularlymphomaresultsfromavalidationstudywithecog2408 AT stephenmbroski prognosticimpactofextranodaldiseaseonpetctinfollicularlymphomaresultsfromavalidationstudywithecog2408 AT zequnsun prognosticimpactofextranodaldiseaseonpetctinfollicularlymphomaresultsfromavalidationstudywithecog2408 AT mashakocherginsky prognosticimpactofextranodaldiseaseonpetctinfollicularlymphomaresultsfromavalidationstudywithecog2408 AT betsylaplant prognosticimpactofextranodaldiseaseonpetctinfollicularlymphomaresultsfromavalidationstudywithecog2408 AT matthewjmaurer prognosticimpactofextranodaldiseaseonpetctinfollicularlymphomaresultsfromavalidationstudywithecog2408 AT andrewquon prognosticimpactofextranodaldiseaseonpetctinfollicularlymphomaresultsfromavalidationstudywithecog2408 AT luciabaratto prognosticimpactofextranodaldiseaseonpetctinfollicularlymphomaresultsfromavalidationstudywithecog2408 AT haticesavas prognosticimpactofextranodaldiseaseonpetctinfollicularlymphomaresultsfromavalidationstudywithecog2408 AT lalekostakoglu prognosticimpactofextranodaldiseaseonpetctinfollicularlymphomaresultsfromavalidationstudywithecog2408 AT janenwinter prognosticimpactofextranodaldiseaseonpetctinfollicularlymphomaresultsfromavalidationstudywithecog2408 AT thomasewitzig prognosticimpactofextranodaldiseaseonpetctinfollicularlymphomaresultsfromavalidationstudywithecog2408 AT bradkahl prognosticimpactofextranodaldiseaseonpetctinfollicularlymphomaresultsfromavalidationstudywithecog2408 AT andrewmevens prognosticimpactofextranodaldiseaseonpetctinfollicularlymphomaresultsfromavalidationstudywithecog2408 AT leoigordon prognosticimpactofextranodaldiseaseonpetctinfollicularlymphomaresultsfromavalidationstudywithecog2408 |