Challenges in Managing Metabolic Syndrome in Psoriasis: A Narrative Review of Pharmacological and Surgical Treatments
Introduction: Psoriasis is a chronic inflammatory disorder associated with multiple systemic comorbidities, most notably metabolic syndrome, which affects approximately one-third of individuals with the disease. Metabolic syndrome—characterized by obesity, insulin resistance, dyslipidemia, and hype...
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Nicolaus Copernicus University in Toruń
2025-04-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/59483 |
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| author | Aleksandra Bętkowska Stanisław Dudek Weronika Koziak Michalina Makieła Agata Kornacka Wojciech Dudek Kamila Szostak Marta Makieła Rafał Tomaka Daniel Worobiej |
| author_facet | Aleksandra Bętkowska Stanisław Dudek Weronika Koziak Michalina Makieła Agata Kornacka Wojciech Dudek Kamila Szostak Marta Makieła Rafał Tomaka Daniel Worobiej |
| author_sort | Aleksandra Bętkowska |
| collection | DOAJ |
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Introduction: Psoriasis is a chronic inflammatory disorder associated with multiple systemic comorbidities, most notably metabolic syndrome, which affects approximately one-third of individuals with the disease. Metabolic syndrome—characterized by obesity, insulin resistance, dyslipidemia, and hypertension—exacerbates systemic inflammation, further complicating disease management and treatment outcomes.
Aim of Study: This review explores the multidisciplinary approach to managing metabolic syndrome in psoriasis, with a particular focus on pharmacological and surgical interventions. It examines the challenges associated with these treatments and their implications for therapeutic efficacy.
Brief Description of the State of Knowledge: Psoriasis and metabolic syndrome share a complex, reciprocal relationship driven by chronic inflammation and metabolic dysregulation. While lifestyle modifications remain the cornerstone of management, many patients require additional pharmacological or surgical interventions. However, the presence of metabolic syndrome can alter the safety and effectiveness of systemic and biologic psoriasis therapies, underscoring the need for a personalized treatment approach.
Conclusions: Effective management requires interdisciplinary collaboration. Pharmacological treatments should minimize metabolic risks, while bariatric surgery may benefit selected patient groups. Further studies are needed to optimize treatment strategies and improve outcomes.
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| format | Article |
| id | doaj-art-827d04d72b8d4b9fab9286799dafe581 |
| institution | OA Journals |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-827d04d72b8d4b9fab9286799dafe5812025-08-20T02:08:31ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-04-014010.12775/QS.2025.40.59483Challenges in Managing Metabolic Syndrome in Psoriasis: A Narrative Review of Pharmacological and Surgical TreatmentsAleksandra Bętkowska0https://orcid.org/0009-0001-5108-4262Stanisław Dudek1https://orcid.org/0009-0002-3641-4865Weronika Koziak2https://orcid.org/0009-0003-5295-5765Michalina Makieła3https://orcid.org/0009-0003-4465-8584Agata Kornacka4https://orcid.org/0009-0007-2877-3514Wojciech Dudek5https://orcid.org/0009-0000-2404-9560Kamila Szostak6https://orcid.org/0009-0005-6216-0864Marta Makieła7https://orcid.org/0009-0005-7199-385XRafał Tomaka8https://orcid.org/0009-0002-5057-6131Daniel Worobiej9https://orcid.org/0009-0002-1153-9821National Medical Institute of the Ministry of the Interior and AdministrationUniversity Clinical Center of the Medical University of Warsaw, Banacha 1A, 02-097 Warsaw, PolandWolski Hospital Dr. Anna Gostyńska, Marcina Kasprzaka 17, 01-211 Warsaw, PolandWolski Hospital Dr. Anna Gostyńska, Marcina Kasprzaka 17, 01-211 Warsaw, PolandUniversity Clinical Center of the Medical University of Warsaw, Banacha 1A, 02-097 Warsaw, PolandMilitary University of Technology, 2 Kaliskiego Street, 00-908 Warsaw, PolandThe Infant Jesus Teaching Hospital, Lindleya 4, 02-005 WarszawaSpitalzentrum Oberwallis (Visp), Pflanzettastrasse 8, 3930 Visp, SwitzerlandUniversity Clinical Center of the Medical University of Warsaw, Banacha 1A, 02-097 Warsaw, PolandWolski Hospital Dr. Anna Gostyńska, Marcina Kasprzaka 17, 01-211 Warsaw, Poland Introduction: Psoriasis is a chronic inflammatory disorder associated with multiple systemic comorbidities, most notably metabolic syndrome, which affects approximately one-third of individuals with the disease. Metabolic syndrome—characterized by obesity, insulin resistance, dyslipidemia, and hypertension—exacerbates systemic inflammation, further complicating disease management and treatment outcomes. Aim of Study: This review explores the multidisciplinary approach to managing metabolic syndrome in psoriasis, with a particular focus on pharmacological and surgical interventions. It examines the challenges associated with these treatments and their implications for therapeutic efficacy. Brief Description of the State of Knowledge: Psoriasis and metabolic syndrome share a complex, reciprocal relationship driven by chronic inflammation and metabolic dysregulation. While lifestyle modifications remain the cornerstone of management, many patients require additional pharmacological or surgical interventions. However, the presence of metabolic syndrome can alter the safety and effectiveness of systemic and biologic psoriasis therapies, underscoring the need for a personalized treatment approach. Conclusions: Effective management requires interdisciplinary collaboration. Pharmacological treatments should minimize metabolic risks, while bariatric surgery may benefit selected patient groups. Further studies are needed to optimize treatment strategies and improve outcomes. https://apcz.umk.pl/QS/article/view/59483metabolic syndromeobesitypsoriasishypoglycemic agentsbariatric surgery |
| spellingShingle | Aleksandra Bętkowska Stanisław Dudek Weronika Koziak Michalina Makieła Agata Kornacka Wojciech Dudek Kamila Szostak Marta Makieła Rafał Tomaka Daniel Worobiej Challenges in Managing Metabolic Syndrome in Psoriasis: A Narrative Review of Pharmacological and Surgical Treatments Quality in Sport metabolic syndrome obesity psoriasis hypoglycemic agents bariatric surgery |
| title | Challenges in Managing Metabolic Syndrome in Psoriasis: A Narrative Review of Pharmacological and Surgical Treatments |
| title_full | Challenges in Managing Metabolic Syndrome in Psoriasis: A Narrative Review of Pharmacological and Surgical Treatments |
| title_fullStr | Challenges in Managing Metabolic Syndrome in Psoriasis: A Narrative Review of Pharmacological and Surgical Treatments |
| title_full_unstemmed | Challenges in Managing Metabolic Syndrome in Psoriasis: A Narrative Review of Pharmacological and Surgical Treatments |
| title_short | Challenges in Managing Metabolic Syndrome in Psoriasis: A Narrative Review of Pharmacological and Surgical Treatments |
| title_sort | challenges in managing metabolic syndrome in psoriasis a narrative review of pharmacological and surgical treatments |
| topic | metabolic syndrome obesity psoriasis hypoglycemic agents bariatric surgery |
| url | https://apcz.umk.pl/QS/article/view/59483 |
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