Fat mass in postmenopausal women with osteoporosis is associated with cognitive function
Abstract Postmenopausal women undergo significant changes in endogenous hormones, which lead to reduced bone mineral density (BMD) and alterations in body composition. However, the relationship between body composition and cognitive function in this demographic has not yet been explored. This study...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-05-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-03523-5 |
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| author | Dongxue Zhang Zijing Zhu Lu Xue Yifeng Zheng Xiongfeng Li Miyang Xu Xinfang Xie Yongli Wang |
| author_facet | Dongxue Zhang Zijing Zhu Lu Xue Yifeng Zheng Xiongfeng Li Miyang Xu Xinfang Xie Yongli Wang |
| author_sort | Dongxue Zhang |
| collection | DOAJ |
| description | Abstract Postmenopausal women undergo significant changes in endogenous hormones, which lead to reduced bone mineral density (BMD) and alterations in body composition. However, the relationship between body composition and cognitive function in this demographic has not yet been explored. This study aims to examine this relationship in postmenopausal women with osteoporosis.This survey will involve 120 postmenopausal women with osteoporosis. Dual-energy X-ray absorptiometry (DXA) will be used to assess L1-L4 BMD, fat mass (FM), trunk fat mass (TFM), fat-free mass (FFM), and appendicular skeletal muscle mass (ASMM). The relationship between body composition and cognitive function will be analyzed using t-tests and multiple linear regression.Our findings suggest that in postmenopausal women with osteoporosis, cognitive function (MMSE score) is positively correlated with body composition indicators such as FM and BMD, and positively correlated with educational level, but negatively correlated with age. FM plays a significant role in influencing cognitive function and is a crucial indicator of body composition in postmenopausal women with osteoporosis. |
| format | Article |
| id | doaj-art-82705a8fed25498ba6161dff27fa1bb2 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-82705a8fed25498ba6161dff27fa1bb22025-08-20T03:08:25ZengNature PortfolioScientific Reports2045-23222025-05-0115111010.1038/s41598-025-03523-5Fat mass in postmenopausal women with osteoporosis is associated with cognitive functionDongxue Zhang0Zijing Zhu1Lu Xue2Yifeng Zheng3Xiongfeng Li4Miyang Xu5Xinfang Xie6Yongli Wang7Huzhou Central Hospital, Affiliated Central Hospital of Huzhou UniversityHuzhou Central Hospital, Affiliated Central Hospital of Huzhou UniversityHuzhou Central Hospital, Affiliated Central Hospital of Huzhou UniversityHuzhou Central Hospital, Affiliated Central Hospital of Huzhou UniversityHuzhou Central Hospital, Affiliated Central Hospital of Huzhou UniversityHuzhou Central Hospital, Fifth School of Clinical Medicine of Zhejiang Chinese Medical UniversityHuzhou Central Hospital, Affiliated Central Hospital of Huzhou UniversityHuzhou Central Hospital, Affiliated Central Hospital of Huzhou UniversityAbstract Postmenopausal women undergo significant changes in endogenous hormones, which lead to reduced bone mineral density (BMD) and alterations in body composition. However, the relationship between body composition and cognitive function in this demographic has not yet been explored. This study aims to examine this relationship in postmenopausal women with osteoporosis.This survey will involve 120 postmenopausal women with osteoporosis. Dual-energy X-ray absorptiometry (DXA) will be used to assess L1-L4 BMD, fat mass (FM), trunk fat mass (TFM), fat-free mass (FFM), and appendicular skeletal muscle mass (ASMM). The relationship between body composition and cognitive function will be analyzed using t-tests and multiple linear regression.Our findings suggest that in postmenopausal women with osteoporosis, cognitive function (MMSE score) is positively correlated with body composition indicators such as FM and BMD, and positively correlated with educational level, but negatively correlated with age. FM plays a significant role in influencing cognitive function and is a crucial indicator of body composition in postmenopausal women with osteoporosis.https://doi.org/10.1038/s41598-025-03523-5Body compositionpostmenopausal osteoporosiscognition functionfat massfat-free mass |
| spellingShingle | Dongxue Zhang Zijing Zhu Lu Xue Yifeng Zheng Xiongfeng Li Miyang Xu Xinfang Xie Yongli Wang Fat mass in postmenopausal women with osteoporosis is associated with cognitive function Scientific Reports Body composition postmenopausal osteoporosis cognition function fat mass fat-free mass |
| title | Fat mass in postmenopausal women with osteoporosis is associated with cognitive function |
| title_full | Fat mass in postmenopausal women with osteoporosis is associated with cognitive function |
| title_fullStr | Fat mass in postmenopausal women with osteoporosis is associated with cognitive function |
| title_full_unstemmed | Fat mass in postmenopausal women with osteoporosis is associated with cognitive function |
| title_short | Fat mass in postmenopausal women with osteoporosis is associated with cognitive function |
| title_sort | fat mass in postmenopausal women with osteoporosis is associated with cognitive function |
| topic | Body composition postmenopausal osteoporosis cognition function fat mass fat-free mass |
| url | https://doi.org/10.1038/s41598-025-03523-5 |
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