Alkaloid Profile Characterisation and Bioactivity Evaluation of Bolivian <i>Hippeastrum</i> Species (Amaryllidaceae) as Cholinesterase Inhibitors
Amaryllidaceae alkaloids from the Amaryllidoideae subfamily exhibit broad pharmacological activities, including neuroprotection and anticancer effects. Galanthamine is a key compound for Alzheimer’s therapy. The <i>Hippeastrum</i> genus, particularly in Bolivia, offers significant potent...
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2025-04-01
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| author | María Lenny Rodríguez-Escobar Raúl Fernando Lara Margoth Atahuachi Alfredo F. Fuentes Carla Maldonado Jaume Bastida Luciana R. Tallini Laura Torras-Claveria |
| author_facet | María Lenny Rodríguez-Escobar Raúl Fernando Lara Margoth Atahuachi Alfredo F. Fuentes Carla Maldonado Jaume Bastida Luciana R. Tallini Laura Torras-Claveria |
| author_sort | María Lenny Rodríguez-Escobar |
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| description | Amaryllidaceae alkaloids from the Amaryllidoideae subfamily exhibit broad pharmacological activities, including neuroprotection and anticancer effects. Galanthamine is a key compound for Alzheimer’s therapy. The <i>Hippeastrum</i> genus, particularly in Bolivia, offers significant potential for novel drug discovery, emphasising the need for conservation and further phytochemical research. Twenty-seven samples from Bolivian <i>Hippeastrum</i> species were investigated in terms of their alkaloid profile and anticholinesterase activity. The phytochemical analysis of Bolivian <i>Hippeastrum</i> species via GC-MS identified 48 Amaryllidaceae alkaloids, displaying diverse structural groups with potential pharmacological significance. Lycorine- and Homolycorine-type alkaloids were predominant, particularly in <i>H. chionedyanthum</i> and <i>H. haywardii</i>, with high concentrations of lycorine, a promising anticancer compound. The species <i>H. evansiarum</i> and <i>H. mollevillquense</i> contained notable quantities of Galanthamine type alkaloids, relevant for Alzheimer’s treatment. This study also highlights variability in acetylcholinesterase and butyrylcholinesterase inhibitory activities, with <i>H. lara-ricoi</i> and <i>H. haywardii</i> demonstrating strong inhibition. These findings suggest that <i>Hippeastrum</i> species are a valuable source of bioactive compounds, warranting further research into their therapeutic applications. |
| format | Article |
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| issn | 2075-1729 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj-art-826e639b360745a39100b3eb7a57b5962025-08-20T01:56:16ZengMDPI AGLife2075-17292025-04-0115571910.3390/life15050719Alkaloid Profile Characterisation and Bioactivity Evaluation of Bolivian <i>Hippeastrum</i> Species (Amaryllidaceae) as Cholinesterase InhibitorsMaría Lenny Rodríguez-Escobar0Raúl Fernando Lara1Margoth Atahuachi2Alfredo F. Fuentes3Carla Maldonado4Jaume Bastida5Luciana R. Tallini6Laura Torras-Claveria7Departament de Biologia, Sanitat i Medi Ambient, Facultat de Farmàcia i Ciències de l’Alimentació, Universitat de Barcelona, Av. Joan XXIII n° 27-31, 08028 Barcelona, SpainHerbario Nacional Forestal Martin Cárdenas (BOLV), Centro de Biodiversidad y Genética, Facultad de Ciencias y Tecnología, Universidad Mayor de San Simón, Calle Sucre y Parque La Torre, Edificio Laboratorios, 4to piso, Cochabamba 4973, BoliviaHerbario Nacional Forestal Martin Cárdenas (BOLV), Centro de Biodiversidad y Genética, Facultad de Ciencias y Tecnología, Universidad Mayor de San Simón, Calle Sucre y Parque La Torre, Edificio Laboratorios, 4to piso, Cochabamba 4973, BoliviaHerbario Nacional de Bolivia (LPB), Instituto de Ecología, Facultad de Ciencias Puras y Naturales, Universidad Mayor de San Andrés, Calle 27 y Andrȳs Bello s/n Cota Cota, Correo Central, La Paz 10077, BoliviaHerbario Nacional de Bolivia (LPB), Instituto de Ecología, Facultad de Ciencias Puras y Naturales, Universidad Mayor de San Andrés, Calle 27 y Andrȳs Bello s/n Cota Cota, Correo Central, La Paz 10077, BoliviaDepartament de Biologia, Sanitat i Medi Ambient, Facultat de Farmàcia i Ciències de l’Alimentació, Universitat de Barcelona, Av. Joan XXIII n° 27-31, 08028 Barcelona, SpainDepartament de Biologia, Sanitat i Medi Ambient, Facultat de Farmàcia i Ciències de l’Alimentació, Universitat de Barcelona, Av. Joan XXIII n° 27-31, 08028 Barcelona, SpainDepartament de Biologia, Sanitat i Medi Ambient, Facultat de Farmàcia i Ciències de l’Alimentació, Universitat de Barcelona, Av. Joan XXIII n° 27-31, 08028 Barcelona, SpainAmaryllidaceae alkaloids from the Amaryllidoideae subfamily exhibit broad pharmacological activities, including neuroprotection and anticancer effects. Galanthamine is a key compound for Alzheimer’s therapy. The <i>Hippeastrum</i> genus, particularly in Bolivia, offers significant potential for novel drug discovery, emphasising the need for conservation and further phytochemical research. Twenty-seven samples from Bolivian <i>Hippeastrum</i> species were investigated in terms of their alkaloid profile and anticholinesterase activity. The phytochemical analysis of Bolivian <i>Hippeastrum</i> species via GC-MS identified 48 Amaryllidaceae alkaloids, displaying diverse structural groups with potential pharmacological significance. Lycorine- and Homolycorine-type alkaloids were predominant, particularly in <i>H. chionedyanthum</i> and <i>H. haywardii</i>, with high concentrations of lycorine, a promising anticancer compound. The species <i>H. evansiarum</i> and <i>H. mollevillquense</i> contained notable quantities of Galanthamine type alkaloids, relevant for Alzheimer’s treatment. This study also highlights variability in acetylcholinesterase and butyrylcholinesterase inhibitory activities, with <i>H. lara-ricoi</i> and <i>H. haywardii</i> demonstrating strong inhibition. These findings suggest that <i>Hippeastrum</i> species are a valuable source of bioactive compounds, warranting further research into their therapeutic applications.https://www.mdpi.com/2075-1729/15/5/719AmaryllidaceaeAmaryllidaceae alkaloids<i>Hippeastrum</i>GC-MSalkaloid profilingacetylcholinesterase |
| spellingShingle | María Lenny Rodríguez-Escobar Raúl Fernando Lara Margoth Atahuachi Alfredo F. Fuentes Carla Maldonado Jaume Bastida Luciana R. Tallini Laura Torras-Claveria Alkaloid Profile Characterisation and Bioactivity Evaluation of Bolivian <i>Hippeastrum</i> Species (Amaryllidaceae) as Cholinesterase Inhibitors Life Amaryllidaceae Amaryllidaceae alkaloids <i>Hippeastrum</i> GC-MS alkaloid profiling acetylcholinesterase |
| title | Alkaloid Profile Characterisation and Bioactivity Evaluation of Bolivian <i>Hippeastrum</i> Species (Amaryllidaceae) as Cholinesterase Inhibitors |
| title_full | Alkaloid Profile Characterisation and Bioactivity Evaluation of Bolivian <i>Hippeastrum</i> Species (Amaryllidaceae) as Cholinesterase Inhibitors |
| title_fullStr | Alkaloid Profile Characterisation and Bioactivity Evaluation of Bolivian <i>Hippeastrum</i> Species (Amaryllidaceae) as Cholinesterase Inhibitors |
| title_full_unstemmed | Alkaloid Profile Characterisation and Bioactivity Evaluation of Bolivian <i>Hippeastrum</i> Species (Amaryllidaceae) as Cholinesterase Inhibitors |
| title_short | Alkaloid Profile Characterisation and Bioactivity Evaluation of Bolivian <i>Hippeastrum</i> Species (Amaryllidaceae) as Cholinesterase Inhibitors |
| title_sort | alkaloid profile characterisation and bioactivity evaluation of bolivian i hippeastrum i species amaryllidaceae as cholinesterase inhibitors |
| topic | Amaryllidaceae Amaryllidaceae alkaloids <i>Hippeastrum</i> GC-MS alkaloid profiling acetylcholinesterase |
| url | https://www.mdpi.com/2075-1729/15/5/719 |
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