Alkaloid Profile Characterisation and Bioactivity Evaluation of Bolivian <i>Hippeastrum</i> Species (Amaryllidaceae) as Cholinesterase Inhibitors
Amaryllidaceae alkaloids from the Amaryllidoideae subfamily exhibit broad pharmacological activities, including neuroprotection and anticancer effects. Galanthamine is a key compound for Alzheimer’s therapy. The <i>Hippeastrum</i> genus, particularly in Bolivia, offers significant potent...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-04-01
|
| Series: | Life |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-1729/15/5/719 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Amaryllidaceae alkaloids from the Amaryllidoideae subfamily exhibit broad pharmacological activities, including neuroprotection and anticancer effects. Galanthamine is a key compound for Alzheimer’s therapy. The <i>Hippeastrum</i> genus, particularly in Bolivia, offers significant potential for novel drug discovery, emphasising the need for conservation and further phytochemical research. Twenty-seven samples from Bolivian <i>Hippeastrum</i> species were investigated in terms of their alkaloid profile and anticholinesterase activity. The phytochemical analysis of Bolivian <i>Hippeastrum</i> species via GC-MS identified 48 Amaryllidaceae alkaloids, displaying diverse structural groups with potential pharmacological significance. Lycorine- and Homolycorine-type alkaloids were predominant, particularly in <i>H. chionedyanthum</i> and <i>H. haywardii</i>, with high concentrations of lycorine, a promising anticancer compound. The species <i>H. evansiarum</i> and <i>H. mollevillquense</i> contained notable quantities of Galanthamine type alkaloids, relevant for Alzheimer’s treatment. This study also highlights variability in acetylcholinesterase and butyrylcholinesterase inhibitory activities, with <i>H. lara-ricoi</i> and <i>H. haywardii</i> demonstrating strong inhibition. These findings suggest that <i>Hippeastrum</i> species are a valuable source of bioactive compounds, warranting further research into their therapeutic applications. |
|---|---|
| ISSN: | 2075-1729 |