Differences in constitutive gene expression of cytochrome P450 enzymes and ATP-binding cassette transporter gene expression between a susceptible and a highly macrocyclic lactone-resistant Haemonchus contortus isolate in the absence of drug-inducible expression

Differences in constitutive gene expression of cytochrome P450 enzymes and ATP-binding cassette transporter gene expression between a susceptible and a highly macrocyclic lactone-resistant Haemonchus contortus isolate in the absence of drug-inducible expression

Abstract Background Anthelmintic resistance in ruminants is a widespread problem that has a severe impact on productivity and animal welfare. The helminth Haemonchus contortus is generally considered the most important parasite in small ruminants due to its high pathogenicity and the widespread occu...

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Bibliographic Details
Main Authors: Natalie Jakobs, Sandro Andreotti, Sabrina Ramünke, Georg von Samson-Himmelstjerna, Jürgen Krücken
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Parasites & Vectors
Subjects:
Haemonchus contortus
Anthelmintic resistance
Cytochrome P450
P-Glycoproteins
ATP-binding cassette transporter
Macrocyclic lactones
Online Access:https://doi.org/10.1186/s13071-024-06568-z
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