Methicillin-Resistant <i>Staphylococcus aureus</i>: The Shifting Landscape in the United Arab Emirates
Background: Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) is a significant burden globally, particularly in the Arabian Gulf region. The United Arab Emirates (UAE) has experienced rising MRSA prevalence, with increasing diversity in the clonal complexes (CCs) identified. The...
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2025-01-01
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| author | Syrine Boucherabine Rania Nassar Lobna Mohamed Maya Habous Anju Nabi Riyaz Amirali Husain Mubarak Alfaresi Seema Oommen Hamda Hassan Khansaheb Mouza Al Sharhan Handan Celiloglu Mubarak Hussain Raja Eman Abdelkarim Nishi Ali Salman Tausif Victory Olowoyeye Nelson Cruz Soares Mahmood Hachim Danesh Moradigaravand Dean Everett Elke Mueller Stefan Monecke Ralf Ehricht Abiola Senok |
| author_facet | Syrine Boucherabine Rania Nassar Lobna Mohamed Maya Habous Anju Nabi Riyaz Amirali Husain Mubarak Alfaresi Seema Oommen Hamda Hassan Khansaheb Mouza Al Sharhan Handan Celiloglu Mubarak Hussain Raja Eman Abdelkarim Nishi Ali Salman Tausif Victory Olowoyeye Nelson Cruz Soares Mahmood Hachim Danesh Moradigaravand Dean Everett Elke Mueller Stefan Monecke Ralf Ehricht Abiola Senok |
| author_sort | Syrine Boucherabine |
| collection | DOAJ |
| description | Background: Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) is a significant burden globally, particularly in the Arabian Gulf region. The United Arab Emirates (UAE) has experienced rising MRSA prevalence, with increasing diversity in the clonal complexes (CCs) identified. The COVID-19 pandemic, with its increased hospitalization rates and antibiotic use, may have further influenced MRSA’s genetic evolution and epidemiology in the country. Methods: To investigate this influence, genomic profiling of 310 MRSA clinical isolates collected between February and November 2022 was performed using a DNA microarray-based assay. Results: Isolates were assigned to 22 clonal complexes and 72 distinct strain assignments. The predominant clonal complexes were CC5, CC6, CC361, CC22, CC1, and CC8. Community-acquired MRSA lineages were dominant, with only one healthcare-associated MRSA lineage isolate identified. Upward trends of CC1153 were observed along with rare CCs, such as CC121-MRSA and CC7-MRSA, with the latter being reported for the first time in the Arabian Gulf region. The presence of pandemic strains USA300 CC8-MRSA-[IVa + ACME1] and CC8-MRSA-IV strains were also observed, including variants lacking Panton–Valentine leukocidin (<i>pvl</i>) genes and missing <i>tst1</i> or enterotoxin genes. The PVL-negative CC772-MRSA-V/VT was identified, representing its first report in the UAE. A novel variant, CC361-MRSA-IV (<i>tst1</i>+/PVL+), was identified. <i>Pvl</i> genes were observed in 36% of the isolates, primarily from skin and soft tissue infections, while <i>fusC</i> (SCC-borne fusidic acid resistance) was identified in 13% of the isolates. Conclusions: The findings highlight the ongoing evolution of MRSA in the UAE, with the persistence and emergence of diverse and rare clonal complexes, driving the need for continuous genomic surveillance. |
| format | Article |
| id | doaj-art-825f97f5b6414d33abd0a54de55858fb |
| institution | Kabale University |
| issn | 2079-6382 |
| language | English |
| publishDate | 2025-01-01 |
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| series | Antibiotics |
| spelling | doaj-art-825f97f5b6414d33abd0a54de55858fb2025-01-24T13:18:35ZengMDPI AGAntibiotics2079-63822025-01-011412410.3390/antibiotics14010024Methicillin-Resistant <i>Staphylococcus aureus</i>: The Shifting Landscape in the United Arab EmiratesSyrine Boucherabine0Rania Nassar1Lobna Mohamed2Maya Habous3Anju Nabi4Riyaz Amirali Husain5Mubarak Alfaresi6Seema Oommen7Hamda Hassan Khansaheb8Mouza Al Sharhan9Handan Celiloglu10Mubarak Hussain Raja11Eman Abdelkarim12Nishi Ali13Salman Tausif14Victory Olowoyeye15Nelson Cruz Soares16Mahmood Hachim17Danesh Moradigaravand18Dean Everett19Elke Mueller20Stefan Monecke21Ralf Ehricht22Abiola Senok23College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai P.O. Box 505055, United Arab EmiratesCollege of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai P.O. Box 505055, United Arab EmiratesCollege of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai P.O. Box 505055, United Arab EmiratesMicrobiology & Infection Control Unit, Pathology Department, Rashid Hospital, Dubai P.O. Box 4545, United Arab EmiratesMicrobiology Department, Dubai Hospital, Dubai P.O. Box 7272, United Arab EmiratesMicrobiology Department, Dubai Hospital, Dubai P.O. Box 7272, United Arab EmiratesDepartment of Microbiology, National Reference Laboratory, Abu Dhabi P.O. Box 92323, United Arab EmiratesLaboratory Department, Burjeel Medical City/CoLAB, Abu Dhabi 92510, United Arab EmiratesCollege of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai P.O. Box 505055, United Arab EmiratesMicrobiology Department, Dubai Hospital, Dubai P.O. Box 7272, United Arab EmiratesMicrobiology Department, Mediclinic City Hospital, Dubai Healthcare City, Dubai P.O. Box 31500, United Arab EmiratesMicrobiology & Infection Control Unit, Pathology Department, Rashid Hospital, Dubai P.O. Box 4545, United Arab EmiratesDubai Academic Health Corporation, Dubai P.O. Box 505055, United Arab EmiratesMicrobiology Department, Mediclinic City Hospital, Dubai Healthcare City, Dubai P.O. Box 31500, United Arab EmiratesMicrobiology Department, Mediclinic City Hospital, Dubai Healthcare City, Dubai P.O. Box 31500, United Arab EmiratesCollege of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai P.O. Box 505055, United Arab EmiratesCenter for Applied and Translational Genomics (CATG), Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai Health, Dubai P.O. Box 505055, United Arab EmiratesCollege of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai P.O. Box 505055, United Arab EmiratesLaboratory of Infectious Disease Epidemiology, Biological and Environmental Science and Engineering (BESE) Division, King Abdullah University of Science and Technology (KAUST), Thuwal P.O. BOX 4700, Saudi ArabiaDepartment of Public Health and Epidemiology, College of Medicine and Health Sciences, Khalifa University, Abu Dhabi P.O. Box 127788, United Arab EmiratesLeibniz Institute of Photonic Technology (IPHT), Leibniz Center for Photonics in Infection Research (LPI), 07745 Jena, GermanyLeibniz Institute of Photonic Technology (IPHT), Leibniz Center for Photonics in Infection Research (LPI), 07745 Jena, GermanyLeibniz Institute of Photonic Technology (IPHT), Leibniz Center for Photonics in Infection Research (LPI), 07745 Jena, GermanyCollege of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai P.O. Box 505055, United Arab EmiratesBackground: Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) is a significant burden globally, particularly in the Arabian Gulf region. The United Arab Emirates (UAE) has experienced rising MRSA prevalence, with increasing diversity in the clonal complexes (CCs) identified. The COVID-19 pandemic, with its increased hospitalization rates and antibiotic use, may have further influenced MRSA’s genetic evolution and epidemiology in the country. Methods: To investigate this influence, genomic profiling of 310 MRSA clinical isolates collected between February and November 2022 was performed using a DNA microarray-based assay. Results: Isolates were assigned to 22 clonal complexes and 72 distinct strain assignments. The predominant clonal complexes were CC5, CC6, CC361, CC22, CC1, and CC8. Community-acquired MRSA lineages were dominant, with only one healthcare-associated MRSA lineage isolate identified. Upward trends of CC1153 were observed along with rare CCs, such as CC121-MRSA and CC7-MRSA, with the latter being reported for the first time in the Arabian Gulf region. The presence of pandemic strains USA300 CC8-MRSA-[IVa + ACME1] and CC8-MRSA-IV strains were also observed, including variants lacking Panton–Valentine leukocidin (<i>pvl</i>) genes and missing <i>tst1</i> or enterotoxin genes. The PVL-negative CC772-MRSA-V/VT was identified, representing its first report in the UAE. A novel variant, CC361-MRSA-IV (<i>tst1</i>+/PVL+), was identified. <i>Pvl</i> genes were observed in 36% of the isolates, primarily from skin and soft tissue infections, while <i>fusC</i> (SCC-borne fusidic acid resistance) was identified in 13% of the isolates. Conclusions: The findings highlight the ongoing evolution of MRSA in the UAE, with the persistence and emergence of diverse and rare clonal complexes, driving the need for continuous genomic surveillance.https://www.mdpi.com/2079-6382/14/1/24MRSAgenotypingmicroarrayantimicrobial resistance<i>Staphylococcus aureus</i> |
| spellingShingle | Syrine Boucherabine Rania Nassar Lobna Mohamed Maya Habous Anju Nabi Riyaz Amirali Husain Mubarak Alfaresi Seema Oommen Hamda Hassan Khansaheb Mouza Al Sharhan Handan Celiloglu Mubarak Hussain Raja Eman Abdelkarim Nishi Ali Salman Tausif Victory Olowoyeye Nelson Cruz Soares Mahmood Hachim Danesh Moradigaravand Dean Everett Elke Mueller Stefan Monecke Ralf Ehricht Abiola Senok Methicillin-Resistant <i>Staphylococcus aureus</i>: The Shifting Landscape in the United Arab Emirates Antibiotics MRSA genotyping microarray antimicrobial resistance <i>Staphylococcus aureus</i> |
| title | Methicillin-Resistant <i>Staphylococcus aureus</i>: The Shifting Landscape in the United Arab Emirates |
| title_full | Methicillin-Resistant <i>Staphylococcus aureus</i>: The Shifting Landscape in the United Arab Emirates |
| title_fullStr | Methicillin-Resistant <i>Staphylococcus aureus</i>: The Shifting Landscape in the United Arab Emirates |
| title_full_unstemmed | Methicillin-Resistant <i>Staphylococcus aureus</i>: The Shifting Landscape in the United Arab Emirates |
| title_short | Methicillin-Resistant <i>Staphylococcus aureus</i>: The Shifting Landscape in the United Arab Emirates |
| title_sort | methicillin resistant i staphylococcus aureus i the shifting landscape in the united arab emirates |
| topic | MRSA genotyping microarray antimicrobial resistance <i>Staphylococcus aureus</i> |
| url | https://www.mdpi.com/2079-6382/14/1/24 |
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