Amyloid‐related changes in fluency in patients with subjective cognitive decline
Abstract INTRODUCTION We examined semantic and phonemic fluency in individuals with subjective cognitive decline (SCD) in relation to amyloid status and clinical progression. METHODS A total of 490 individuals with SCD (62 ± 8 years, 42% female, 28% amyloid‐positive, 17% clinical progression) comple...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
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| Online Access: | https://doi.org/10.1002/dad2.70063 |
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| author | Rosanne L. vanden Berg Elke Butterbrod Casper deBoer Lisa‐Marie Schlüter Argonde C. vanHarten Charlotte E. Teunissen Elsmarieke van deGiessen Wiesje M. van derFlier Sietske A. M. Sikkes |
| author_facet | Rosanne L. vanden Berg Elke Butterbrod Casper deBoer Lisa‐Marie Schlüter Argonde C. vanHarten Charlotte E. Teunissen Elsmarieke van deGiessen Wiesje M. van derFlier Sietske A. M. Sikkes |
| author_sort | Rosanne L. vanden Berg |
| collection | DOAJ |
| description | Abstract INTRODUCTION We examined semantic and phonemic fluency in individuals with subjective cognitive decline (SCD) in relation to amyloid status and clinical progression. METHODS A total of 490 individuals with SCD (62 ± 8 years, 42% female, 28% amyloid‐positive, 17% clinical progression) completed annual fluency assessments (mean ± SD follow‐up 4.3 ± 2.9 years). Associations between fluency trajectories, amyloid status, and clinical progression were examined with linear mixed models and joint models. RESULTS Amyloid‐positive individuals declined faster than amyloid‐negative individuals on semantic fluency (B = −0.35, p < 0.001), but not on phonemic fluency (B = −0.06, p = 0.218). An annual decline of one word in semantic and phonemic fluency was associated with 22% (hazard ratio [HR] = 1.22, p < 0.001) and 28% (HR = 1.28, p = 0.004) increased risk of clinical progression. DISCUSSION Our results indicate that decline in semantic fluency is an early indicator of cognitive deficits in preclinical Alzheimer's disease. Highlights Abnormal amyloid burden is associated with decline in semantic fluency. Fluency trajectories are associated with an increased risk of clinical progression. More refined measures are needed to detect the earliest language deficits. |
| format | Article |
| id | doaj-art-825c14962ea04b1cad0f3fc8783ab015 |
| institution | Kabale University |
| issn | 2352-8729 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj-art-825c14962ea04b1cad0f3fc8783ab0152025-08-20T03:42:18ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292025-01-01171n/an/a10.1002/dad2.70063Amyloid‐related changes in fluency in patients with subjective cognitive declineRosanne L. vanden Berg0Elke Butterbrod1Casper deBoer2Lisa‐Marie Schlüter3Argonde C. vanHarten4Charlotte E. Teunissen5Elsmarieke van deGiessen6Wiesje M. van derFlier7Sietske A. M. Sikkes8Alzheimer Center Amsterdam, Neurology Amsterdam University Medical Center Amsterdam the NetherlandsAlzheimer Center Amsterdam, Neurology Amsterdam University Medical Center Amsterdam the NetherlandsAlzheimer Center Amsterdam, Neurology Amsterdam University Medical Center Amsterdam the NetherlandsAlzheimer Center Amsterdam, Neurology Amsterdam University Medical Center Amsterdam the NetherlandsAlzheimer Center Amsterdam, Neurology Amsterdam University Medical Center Amsterdam the NetherlandsAmsterdam Neuroscience, Neurodegeneration Amsterdam the NetherlandsDepartment of Radiology & Nuclear Medicine Amsterdam University Medical Center Amsterdam the NetherlandsAlzheimer Center Amsterdam, Neurology Amsterdam University Medical Center Amsterdam the NetherlandsAlzheimer Center Amsterdam, Neurology Amsterdam University Medical Center Amsterdam the NetherlandsAbstract INTRODUCTION We examined semantic and phonemic fluency in individuals with subjective cognitive decline (SCD) in relation to amyloid status and clinical progression. METHODS A total of 490 individuals with SCD (62 ± 8 years, 42% female, 28% amyloid‐positive, 17% clinical progression) completed annual fluency assessments (mean ± SD follow‐up 4.3 ± 2.9 years). Associations between fluency trajectories, amyloid status, and clinical progression were examined with linear mixed models and joint models. RESULTS Amyloid‐positive individuals declined faster than amyloid‐negative individuals on semantic fluency (B = −0.35, p < 0.001), but not on phonemic fluency (B = −0.06, p = 0.218). An annual decline of one word in semantic and phonemic fluency was associated with 22% (hazard ratio [HR] = 1.22, p < 0.001) and 28% (HR = 1.28, p = 0.004) increased risk of clinical progression. DISCUSSION Our results indicate that decline in semantic fluency is an early indicator of cognitive deficits in preclinical Alzheimer's disease. Highlights Abnormal amyloid burden is associated with decline in semantic fluency. Fluency trajectories are associated with an increased risk of clinical progression. More refined measures are needed to detect the earliest language deficits.https://doi.org/10.1002/dad2.70063Alzheimer's diseaseamyloid positivelanguagelongitudinalsubjective cognitive declineverbal fluency |
| spellingShingle | Rosanne L. vanden Berg Elke Butterbrod Casper deBoer Lisa‐Marie Schlüter Argonde C. vanHarten Charlotte E. Teunissen Elsmarieke van deGiessen Wiesje M. van derFlier Sietske A. M. Sikkes Amyloid‐related changes in fluency in patients with subjective cognitive decline Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Alzheimer's disease amyloid positive language longitudinal subjective cognitive decline verbal fluency |
| title | Amyloid‐related changes in fluency in patients with subjective cognitive decline |
| title_full | Amyloid‐related changes in fluency in patients with subjective cognitive decline |
| title_fullStr | Amyloid‐related changes in fluency in patients with subjective cognitive decline |
| title_full_unstemmed | Amyloid‐related changes in fluency in patients with subjective cognitive decline |
| title_short | Amyloid‐related changes in fluency in patients with subjective cognitive decline |
| title_sort | amyloid related changes in fluency in patients with subjective cognitive decline |
| topic | Alzheimer's disease amyloid positive language longitudinal subjective cognitive decline verbal fluency |
| url | https://doi.org/10.1002/dad2.70063 |
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