An in silico approach deciphering the commensal dynamics in the cutaneous milieu
Abstract The skin microbiota, particularly coagulase-negative staphylococci (CoNS) such as S. epidermidis, plays a crucial role in maintaining skin health and immunity. S. epidermidis, a predominant commensal species, interacts intimately with keratinocytes to regulate immune responses and antimicro...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-05-01
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| Series: | npj Systems Biology and Applications |
| Online Access: | https://doi.org/10.1038/s41540-025-00524-y |
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| author | Sumathi Kalankariyan Anjana Thottapillil Abha Saxena Manoj Srivatsn S Vinitha Kadamkode Renu Kapoor Rupak Mitra Janhavi Raut KV Venkatesh |
| author_facet | Sumathi Kalankariyan Anjana Thottapillil Abha Saxena Manoj Srivatsn S Vinitha Kadamkode Renu Kapoor Rupak Mitra Janhavi Raut KV Venkatesh |
| author_sort | Sumathi Kalankariyan |
| collection | DOAJ |
| description | Abstract The skin microbiota, particularly coagulase-negative staphylococci (CoNS) such as S. epidermidis, plays a crucial role in maintaining skin health and immunity. S. epidermidis, a predominant commensal species, interacts intimately with keratinocytes to regulate immune responses and antimicrobial defence mechanisms. Metabolic byproducts like short-chain fatty acids (SCFAs) influence keratinocyte activation, while cell wall components engage Toll-like receptors (TLRs) to modulate inflammation. These interactions are fundamental for preserving skin homeostasis and combating pathogenic invaders. Our comprehensive mathematical model, integrating commensal dynamics, immune responses, and skin microenvironment variables, provides insights into these intricate interactions. The model delves into the complexities of skin scenarios and perturbations, aiming to understand the colonization dynamics of S. epidermidis and its influence on skin barrier functions. It examines how disruptions in key factors such as AMP, growth factor-mediated repair pathways, and filaggrin mutations influence the behaviour of the system. The study depicts the skin microenvironment as a highly dynamic one, highlighting the critical role of S. epidermidis and capturing its role in barrier dysfunction caused by internal and external factors. By offering insights into skin barrier function and immune responses, the model illuminates key interactions of commensals within the skin microenvironment which can ultimately benefit skin health. |
| format | Article |
| id | doaj-art-824c8e32c2694ea89e4649d54b1da76e |
| institution | DOAJ |
| issn | 2056-7189 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Systems Biology and Applications |
| spelling | doaj-art-824c8e32c2694ea89e4649d54b1da76e2025-08-20T03:09:20ZengNature Portfolionpj Systems Biology and Applications2056-71892025-05-0111111110.1038/s41540-025-00524-yAn in silico approach deciphering the commensal dynamics in the cutaneous milieuSumathi Kalankariyan0Anjana Thottapillil1Abha Saxena2Manoj Srivatsn S3Vinitha Kadamkode4Renu Kapoor5Rupak Mitra6Janhavi Raut7KV Venkatesh8MetFlux Research Private LimitedMetFlux Research Private LimitedMetFlux Research Private LimitedMetFlux Research Private LimitedUnilever R & DUnilever R & DUnilever R & DUnilever R & DMetFlux Research Private LimitedAbstract The skin microbiota, particularly coagulase-negative staphylococci (CoNS) such as S. epidermidis, plays a crucial role in maintaining skin health and immunity. S. epidermidis, a predominant commensal species, interacts intimately with keratinocytes to regulate immune responses and antimicrobial defence mechanisms. Metabolic byproducts like short-chain fatty acids (SCFAs) influence keratinocyte activation, while cell wall components engage Toll-like receptors (TLRs) to modulate inflammation. These interactions are fundamental for preserving skin homeostasis and combating pathogenic invaders. Our comprehensive mathematical model, integrating commensal dynamics, immune responses, and skin microenvironment variables, provides insights into these intricate interactions. The model delves into the complexities of skin scenarios and perturbations, aiming to understand the colonization dynamics of S. epidermidis and its influence on skin barrier functions. It examines how disruptions in key factors such as AMP, growth factor-mediated repair pathways, and filaggrin mutations influence the behaviour of the system. The study depicts the skin microenvironment as a highly dynamic one, highlighting the critical role of S. epidermidis and capturing its role in barrier dysfunction caused by internal and external factors. By offering insights into skin barrier function and immune responses, the model illuminates key interactions of commensals within the skin microenvironment which can ultimately benefit skin health.https://doi.org/10.1038/s41540-025-00524-y |
| spellingShingle | Sumathi Kalankariyan Anjana Thottapillil Abha Saxena Manoj Srivatsn S Vinitha Kadamkode Renu Kapoor Rupak Mitra Janhavi Raut KV Venkatesh An in silico approach deciphering the commensal dynamics in the cutaneous milieu npj Systems Biology and Applications |
| title | An in silico approach deciphering the commensal dynamics in the cutaneous milieu |
| title_full | An in silico approach deciphering the commensal dynamics in the cutaneous milieu |
| title_fullStr | An in silico approach deciphering the commensal dynamics in the cutaneous milieu |
| title_full_unstemmed | An in silico approach deciphering the commensal dynamics in the cutaneous milieu |
| title_short | An in silico approach deciphering the commensal dynamics in the cutaneous milieu |
| title_sort | in silico approach deciphering the commensal dynamics in the cutaneous milieu |
| url | https://doi.org/10.1038/s41540-025-00524-y |
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