Predictors of Acquired Perforating Dermatosis in Uremic Patients on Hemodialysis: A Case-Control Study

Objectives. The purpose of this study was to identify the predictors of acquired perforating dermatosis (APD) in patients on maintenance hemodialysis (HD). Methods. A case-control study was performed at our outpatient HD center between January 1, 2000 and March 31, 2011. Patients on HD with APD were...

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Main Authors: Cheng-Hao Weng, Ching-Chih Hu, Shir-Hwa Ueng, Chun-Chen Yu, Chung-Yee Hui, Ja-Liang Lin, Chih-Wei Yang, Cheng-Chieh Hung, Ching-Wei Hsu, Tzung-Hai Yen
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1100/2012/158075
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author Cheng-Hao Weng
Ching-Chih Hu
Shir-Hwa Ueng
Chun-Chen Yu
Chung-Yee Hui
Ja-Liang Lin
Chih-Wei Yang
Cheng-Chieh Hung
Ching-Wei Hsu
Tzung-Hai Yen
author_facet Cheng-Hao Weng
Ching-Chih Hu
Shir-Hwa Ueng
Chun-Chen Yu
Chung-Yee Hui
Ja-Liang Lin
Chih-Wei Yang
Cheng-Chieh Hung
Ching-Wei Hsu
Tzung-Hai Yen
author_sort Cheng-Hao Weng
collection DOAJ
description Objectives. The purpose of this study was to identify the predictors of acquired perforating dermatosis (APD) in patients on maintenance hemodialysis (HD). Methods. A case-control study was performed at our outpatient HD center between January 1, 2000 and March 31, 2011. Patients on HD with APD were matched (1 : 2) for gender and age with controls on HD. Conditional logistic regression was used to identify factors associated with APD. Results. A total of 19 patients with APD and 38 age and gender matched patients were enrolled in the study. Univariate logistic regression showed that APD was significantly associated with diabetes mellitus (DM), reduced levels of intact parathyroid hormone (iPTH) and albumin (Alb), reduced dialysis adequacy () and urea reduction rate (URR), and elevated levels of high-sensitivity C-reactive protein (hsCRP). Multivariate logistic regression identified reduced iPTH (hazard ratio (HR): 0.983; ) and Alb (HR: 0.099; ) and elevated hsCRP (HR: 1.210, ) as risk factors for APD. Conclusions. iPTH, hsCRP, and Alb are predictors for APD in HD patients.
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spelling doaj-art-82484f9265f44918a3b1418817ed8ba22025-02-03T01:21:30ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/158075158075Predictors of Acquired Perforating Dermatosis in Uremic Patients on Hemodialysis: A Case-Control StudyCheng-Hao Weng0Ching-Chih Hu1Shir-Hwa Ueng2Chun-Chen Yu3Chung-Yee Hui4Ja-Liang Lin5Chih-Wei Yang6Cheng-Chieh Hung7Ching-Wei Hsu8Tzung-Hai Yen9Department of Nephrology, Chang Gung Memorial Hospital, 5 Fu-Shin Street, Kwei-Shan, Taoyuan 333, TaiwanCollege of Medicine, Chang Gung University, Taoyuan 333, TaiwanCollege of Medicine, Chang Gung University, Taoyuan 333, TaiwanDepartment of Nephrology, Chang Gung Memorial Hospital, 5 Fu-Shin Street, Kwei-Shan, Taoyuan 333, TaiwanCollege of Medicine, Chang Gung University, Taoyuan 333, TaiwanDepartment of Nephrology, Chang Gung Memorial Hospital, 5 Fu-Shin Street, Kwei-Shan, Taoyuan 333, TaiwanDepartment of Nephrology, Chang Gung Memorial Hospital, 5 Fu-Shin Street, Kwei-Shan, Taoyuan 333, TaiwanDepartment of Nephrology, Chang Gung Memorial Hospital, 5 Fu-Shin Street, Kwei-Shan, Taoyuan 333, TaiwanDepartment of Nephrology, Chang Gung Memorial Hospital, 5 Fu-Shin Street, Kwei-Shan, Taoyuan 333, TaiwanDepartment of Nephrology, Chang Gung Memorial Hospital, 5 Fu-Shin Street, Kwei-Shan, Taoyuan 333, TaiwanObjectives. The purpose of this study was to identify the predictors of acquired perforating dermatosis (APD) in patients on maintenance hemodialysis (HD). Methods. A case-control study was performed at our outpatient HD center between January 1, 2000 and March 31, 2011. Patients on HD with APD were matched (1 : 2) for gender and age with controls on HD. Conditional logistic regression was used to identify factors associated with APD. Results. A total of 19 patients with APD and 38 age and gender matched patients were enrolled in the study. Univariate logistic regression showed that APD was significantly associated with diabetes mellitus (DM), reduced levels of intact parathyroid hormone (iPTH) and albumin (Alb), reduced dialysis adequacy () and urea reduction rate (URR), and elevated levels of high-sensitivity C-reactive protein (hsCRP). Multivariate logistic regression identified reduced iPTH (hazard ratio (HR): 0.983; ) and Alb (HR: 0.099; ) and elevated hsCRP (HR: 1.210, ) as risk factors for APD. Conclusions. iPTH, hsCRP, and Alb are predictors for APD in HD patients.http://dx.doi.org/10.1100/2012/158075
spellingShingle Cheng-Hao Weng
Ching-Chih Hu
Shir-Hwa Ueng
Chun-Chen Yu
Chung-Yee Hui
Ja-Liang Lin
Chih-Wei Yang
Cheng-Chieh Hung
Ching-Wei Hsu
Tzung-Hai Yen
Predictors of Acquired Perforating Dermatosis in Uremic Patients on Hemodialysis: A Case-Control Study
The Scientific World Journal
title Predictors of Acquired Perforating Dermatosis in Uremic Patients on Hemodialysis: A Case-Control Study
title_full Predictors of Acquired Perforating Dermatosis in Uremic Patients on Hemodialysis: A Case-Control Study
title_fullStr Predictors of Acquired Perforating Dermatosis in Uremic Patients on Hemodialysis: A Case-Control Study
title_full_unstemmed Predictors of Acquired Perforating Dermatosis in Uremic Patients on Hemodialysis: A Case-Control Study
title_short Predictors of Acquired Perforating Dermatosis in Uremic Patients on Hemodialysis: A Case-Control Study
title_sort predictors of acquired perforating dermatosis in uremic patients on hemodialysis a case control study
url http://dx.doi.org/10.1100/2012/158075
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