Substrate stiffness regulates triple-negative breast cancer signaling through CXCR4 receptor dynamics

Substrate stiffness regulates triple-negative breast cancer signaling through CXCR4 receptor dynamics

Abstract Biophysical properties of the extracellular matrix (ECM), such as mechanical stiffness, directly regulate behaviors of cancer cells linked to cancer initiation and progression. Cells sense and respond to ECM stiffness in the context of dynamic changes in biochemical inputs, such as growth f...

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Bibliographic Details
Main Authors: Kenneth K. Y. Ho, Johanna M. Buschhaus, Anne Zhang, Alyssa C. Cutter, Brock A. Humphries, Gary D. Luker
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Triple-negative breast cancer
CXCR4
Signaling dynamics
ERK
Akt
Extracellular matrix
Online Access:https://doi.org/10.1038/s41598-025-14495-x
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