Towards harmonized holmium-166 SPECT image quality for dosimetry: a multi-center, multi-vendor study
Abstract Background Reliable dosimetry based on SPECT/CT imaging is essential to achieve personalized 166Ho-radioembolization treatment planning and evaluation. This study quantitatively evaluates multiple acquisition and reconstruction protocols for 166Ho-SPECT imaging based on data from five Dutch...
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SpringerOpen
2025-03-01
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| Series: | EJNMMI Physics |
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| Online Access: | https://doi.org/10.1186/s40658-025-00733-8 |
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| author | Lovisa E. L. Westlund Gotby Martina Stella Camille D. E. Van Speybroeck Daphne Lobeek Floris H. P. van Velden Mette K. Stam Petra Dibbets-Schneider Daphne M. V. de Vries-Huizing Erik-Jan Rijkhorst Berlinda J. de Wit-van de Veen Roel Wierts Rob van Rooij |
| author_facet | Lovisa E. L. Westlund Gotby Martina Stella Camille D. E. Van Speybroeck Daphne Lobeek Floris H. P. van Velden Mette K. Stam Petra Dibbets-Schneider Daphne M. V. de Vries-Huizing Erik-Jan Rijkhorst Berlinda J. de Wit-van de Veen Roel Wierts Rob van Rooij |
| author_sort | Lovisa E. L. Westlund Gotby |
| collection | DOAJ |
| description | Abstract Background Reliable dosimetry based on SPECT/CT imaging is essential to achieve personalized 166Ho-radioembolization treatment planning and evaluation. This study quantitatively evaluates multiple acquisition and reconstruction protocols for 166Ho-SPECT imaging based on data from five Dutch hospitals. We aim to recommend an imaging protocol which harmonizes 166Ho-SPECT images for reproducible and accurate dosimetry in a multi-scanner and multi-center setting. Methods Cylindrical and NEMA IEC phantoms, filled with 166Ho-chloride, were imaged using seven SPECT/CT scanners from two vendors (GE HealthCare and Siemens Healthineers). Data were acquired with a photopeak window centered at 81 keV. Two adjacent scatter windows, and one upper scatter window at 118 keV were used for triple-energy window (TEW) and dual-energy window (DEW) scatter correction, respectively. The TEW and DEW reconstructions used vendor-specific software. Additionally, a vendor-neutral software package with Monte Carlo (MC) scatter correction (Hermes Medical Solutions) was used to study the influence of scanner hardware on the image quality. System sensitivity was measured in projection data of the cylindrical phantom. The axial uniformity in the cylindrical phantom was used to characterize the impact of the scatter correction method. The image quality was evaluated by the coefficient of variation (COV; noise), the contrast recovery coefficients (CRCs) and contrast-to-noise ratios (CNRs). Results TEW scatter correction resulted in superior uniformity and higher CRCs compared to the DEW (CRC for the largest sphere over all scanners, mean ± SD (range): TEW 0.54 ± 0.07 (0.36–0.65), DEW 0.44 ± 0.04 (0.34–0.51)). DEW resulted in lower noise levels compared to TEW (16% lower on average). The DEW and TEW images resulted in comparable CNRs. The system sensitivities and the vendor-neutral image reconstructions demonstrated differences in hardware between the two vendors, most likely due to the characteristics of the vendor-specific medium energy collimator. Conclusion This study demonstrates that TEW scatter correction increases the accuracy of 166Ho-SPECT images compared to DEW, and we henceforth recommend adopting this method in the clinical 166Ho-dosimetry workflow. Scanner hardware has a substantial impact on the characteristics of the acquired data, and identical reconstruction settings will therefore not automatically lead to harmonized image quality. |
| format | Article |
| id | doaj-art-8233eed3a88f4d619a5cc73090e25aae |
| institution | DOAJ |
| issn | 2197-7364 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | SpringerOpen |
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| series | EJNMMI Physics |
| spelling | doaj-art-8233eed3a88f4d619a5cc73090e25aae2025-08-20T02:41:35ZengSpringerOpenEJNMMI Physics2197-73642025-03-0112111910.1186/s40658-025-00733-8Towards harmonized holmium-166 SPECT image quality for dosimetry: a multi-center, multi-vendor studyLovisa E. L. Westlund Gotby0Martina Stella1Camille D. E. Van Speybroeck2Daphne Lobeek3Floris H. P. van Velden4Mette K. Stam5Petra Dibbets-Schneider6Daphne M. V. de Vries-Huizing7Erik-Jan Rijkhorst8Berlinda J. de Wit-van de Veen9Roel Wierts10Rob van Rooij11Department of Medical Imaging, Radboud University Medical CenterDepartment of Radiology and Nuclear Medicine, University Medical Centre UtrechtDepartment of Medical Imaging, Radboud University Medical CenterDepartment of Medical Imaging, Radboud University Medical CenterDepartment of Radiology, Section of Nuclear Medicine, Leiden University Medical CenterDepartment of Radiology, Section of Nuclear Medicine, Leiden University Medical CenterDepartment of Radiology, Section of Nuclear Medicine, Leiden University Medical CenterDepartment of Nuclear Medicine, Netherlands Cancer InstituteDepartment of Nuclear Medicine, Netherlands Cancer InstituteDepartment of Nuclear Medicine, Netherlands Cancer InstituteDepartment of Radiology and Nuclear Medicine, Maastricht University Medical CenterDepartment of Radiology and Nuclear Medicine, University Medical Centre UtrechtAbstract Background Reliable dosimetry based on SPECT/CT imaging is essential to achieve personalized 166Ho-radioembolization treatment planning and evaluation. This study quantitatively evaluates multiple acquisition and reconstruction protocols for 166Ho-SPECT imaging based on data from five Dutch hospitals. We aim to recommend an imaging protocol which harmonizes 166Ho-SPECT images for reproducible and accurate dosimetry in a multi-scanner and multi-center setting. Methods Cylindrical and NEMA IEC phantoms, filled with 166Ho-chloride, were imaged using seven SPECT/CT scanners from two vendors (GE HealthCare and Siemens Healthineers). Data were acquired with a photopeak window centered at 81 keV. Two adjacent scatter windows, and one upper scatter window at 118 keV were used for triple-energy window (TEW) and dual-energy window (DEW) scatter correction, respectively. The TEW and DEW reconstructions used vendor-specific software. Additionally, a vendor-neutral software package with Monte Carlo (MC) scatter correction (Hermes Medical Solutions) was used to study the influence of scanner hardware on the image quality. System sensitivity was measured in projection data of the cylindrical phantom. The axial uniformity in the cylindrical phantom was used to characterize the impact of the scatter correction method. The image quality was evaluated by the coefficient of variation (COV; noise), the contrast recovery coefficients (CRCs) and contrast-to-noise ratios (CNRs). Results TEW scatter correction resulted in superior uniformity and higher CRCs compared to the DEW (CRC for the largest sphere over all scanners, mean ± SD (range): TEW 0.54 ± 0.07 (0.36–0.65), DEW 0.44 ± 0.04 (0.34–0.51)). DEW resulted in lower noise levels compared to TEW (16% lower on average). The DEW and TEW images resulted in comparable CNRs. The system sensitivities and the vendor-neutral image reconstructions demonstrated differences in hardware between the two vendors, most likely due to the characteristics of the vendor-specific medium energy collimator. Conclusion This study demonstrates that TEW scatter correction increases the accuracy of 166Ho-SPECT images compared to DEW, and we henceforth recommend adopting this method in the clinical 166Ho-dosimetry workflow. Scanner hardware has a substantial impact on the characteristics of the acquired data, and identical reconstruction settings will therefore not automatically lead to harmonized image quality.https://doi.org/10.1186/s40658-025-00733-8Holmium-166SPECT/CTRadioembolizationPhantom studyImage qualityDual-energy window scatter correction |
| spellingShingle | Lovisa E. L. Westlund Gotby Martina Stella Camille D. E. Van Speybroeck Daphne Lobeek Floris H. P. van Velden Mette K. Stam Petra Dibbets-Schneider Daphne M. V. de Vries-Huizing Erik-Jan Rijkhorst Berlinda J. de Wit-van de Veen Roel Wierts Rob van Rooij Towards harmonized holmium-166 SPECT image quality for dosimetry: a multi-center, multi-vendor study EJNMMI Physics Holmium-166 SPECT/CT Radioembolization Phantom study Image quality Dual-energy window scatter correction |
| title | Towards harmonized holmium-166 SPECT image quality for dosimetry: a multi-center, multi-vendor study |
| title_full | Towards harmonized holmium-166 SPECT image quality for dosimetry: a multi-center, multi-vendor study |
| title_fullStr | Towards harmonized holmium-166 SPECT image quality for dosimetry: a multi-center, multi-vendor study |
| title_full_unstemmed | Towards harmonized holmium-166 SPECT image quality for dosimetry: a multi-center, multi-vendor study |
| title_short | Towards harmonized holmium-166 SPECT image quality for dosimetry: a multi-center, multi-vendor study |
| title_sort | towards harmonized holmium 166 spect image quality for dosimetry a multi center multi vendor study |
| topic | Holmium-166 SPECT/CT Radioembolization Phantom study Image quality Dual-energy window scatter correction |
| url | https://doi.org/10.1186/s40658-025-00733-8 |
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