A comprehensive consolidation of data on the connection between CDKN2A polymorphisms and the susceptibility to childhood acute lymphoblastic leukemia
Background: Acute lymphoblastic leukemia is the predominant neoplastic ailment in childhood. Prior research has already established noteworthy connections between CDKN2A polymorphisms and susceptibility to this childhood leukemia, however, substantial associations are still awaiting validation. This...
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Elsevier
2024-12-01
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| Series: | Hematology, Transfusion and Cell Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2531137924028141 |
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| author | Maryam Aghasipour Fatemeh Asadian Seyed Alireza Dastgheib Abolhasan Alijanpour Ali Masoudi Maedeh Barahman Mohammad Golshan-Tafti Reza Bahrami Amirmasoud Shiri Hossein Aarafi Kazem Aghili Hossein Neamatzadeh |
| author_facet | Maryam Aghasipour Fatemeh Asadian Seyed Alireza Dastgheib Abolhasan Alijanpour Ali Masoudi Maedeh Barahman Mohammad Golshan-Tafti Reza Bahrami Amirmasoud Shiri Hossein Aarafi Kazem Aghili Hossein Neamatzadeh |
| author_sort | Maryam Aghasipour |
| collection | DOAJ |
| description | Background: Acute lymphoblastic leukemia is the predominant neoplastic ailment in childhood. Prior research has already established noteworthy connections between CDKN2A polymorphisms and susceptibility to this childhood leukemia, however, substantial associations are still awaiting validation. This investigation was undertaken to examine the correlation between CDKN2A polymorphisms and the risk of acute lymphoblastic leukemia in children. Methods: Acquisition of information encompassed the exploration of diverse databases including PubMed, Scopus, EMBASE, and China National Knowledge Infrastructure (CNKI) until January 10, 2024. An estimation of associations was achieved utilizing odds ratios with 95% confidence intervals. Results: A total of 22 case-control studies encompassing 10,203 cases of acute lymphoblastic leukemia and 36,424 healthy controls were included. Within this pool of studies, 14 focused on rs3731217, comprising 5396 cases and 15,787 controls, whereas eight studies investigated rs3731249, comprising 4807 cases and 20,637 controls. The aggregated data showed that the rs3731217 variant offers protection against acute lymphoblastic leukemia. Nevertheless, when subgroups are analyzed according to ethnicity, it becomes clear that the rs3731217 polymorphism significantly influences susceptibility, particularly among individuals of Caucasian and African descent with no such association being observed in children of Asian origin. Nevertheless, the rs3731249 polymorphism displayed a noteworthy correlation with vulnerability to pediatric acute lymphoblastic leukemia. Conclusion: The aggregated data revealed that the rs3731217 variation offers protection against the development of pediatric acute lymphoblastic leukemia and the rs3731249 polymorphism is significantly correlated with susceptibility. |
| format | Article |
| id | doaj-art-8233b154e1294488bc2fee5e8d3937f0 |
| institution | OA Journals |
| issn | 2531-1379 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hematology, Transfusion and Cell Therapy |
| spelling | doaj-art-8233b154e1294488bc2fee5e8d3937f02025-08-20T01:57:00ZengElsevierHematology, Transfusion and Cell Therapy2531-13792024-12-0146S332S34510.1016/j.htct.2024.05.017A comprehensive consolidation of data on the connection between CDKN2A polymorphisms and the susceptibility to childhood acute lymphoblastic leukemiaMaryam Aghasipour0Fatemeh Asadian1Seyed Alireza Dastgheib2Abolhasan Alijanpour3Ali Masoudi4Maedeh Barahman5Mohammad Golshan-Tafti6Reza Bahrami7Amirmasoud Shiri8Hossein Aarafi9Kazem Aghili10Hossein Neamatzadeh11College of Medicine, University of Cincinnati, Ohio, USASchool of Paramedical Science, Shiraz University of Medical Sciences, Shiraz, Iran; Corresponding author at: Department of Medical Laboratory Sciences, School of Paramedical Science, Shiraz University of Medical Sciences, Shiraz, Iran.School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranBabol University of Medical Sciences, Babol, IranShahid Sadoughi University of Medical Sciences, Yazd, IranFiroozgar Hospital, Firoozgar Clinical Research Development Center (FCRDC), Iran University of Medical Sciences, Tehran, IranIslamic Azad University of Yazd, Yazd, IranNeonatal Research Center, Shiraz University of Medical Sciences, Shiraz, IranSchool of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, IranIslamic Azad University of Yazd, Yazd, IranCollege of Medicine, University of Cincinnati, Ohio, USA; School of Paramedical Science, Shiraz University of Medical Sciences, Shiraz, Iran; School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Babol University of Medical Sciences, Babol, Iran; Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Firoozgar Hospital, Firoozgar Clinical Research Development Center (FCRDC), Iran University of Medical Sciences, Tehran, Iran; Islamic Azad University of Yazd, Yazd, Iran; Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Shahid Rahnamoun Hospital, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Mother and Newborn Health Research Center, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, IranMother and Newborn Health Research Center, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, IranBackground: Acute lymphoblastic leukemia is the predominant neoplastic ailment in childhood. Prior research has already established noteworthy connections between CDKN2A polymorphisms and susceptibility to this childhood leukemia, however, substantial associations are still awaiting validation. This investigation was undertaken to examine the correlation between CDKN2A polymorphisms and the risk of acute lymphoblastic leukemia in children. Methods: Acquisition of information encompassed the exploration of diverse databases including PubMed, Scopus, EMBASE, and China National Knowledge Infrastructure (CNKI) until January 10, 2024. An estimation of associations was achieved utilizing odds ratios with 95% confidence intervals. Results: A total of 22 case-control studies encompassing 10,203 cases of acute lymphoblastic leukemia and 36,424 healthy controls were included. Within this pool of studies, 14 focused on rs3731217, comprising 5396 cases and 15,787 controls, whereas eight studies investigated rs3731249, comprising 4807 cases and 20,637 controls. The aggregated data showed that the rs3731217 variant offers protection against acute lymphoblastic leukemia. Nevertheless, when subgroups are analyzed according to ethnicity, it becomes clear that the rs3731217 polymorphism significantly influences susceptibility, particularly among individuals of Caucasian and African descent with no such association being observed in children of Asian origin. Nevertheless, the rs3731249 polymorphism displayed a noteworthy correlation with vulnerability to pediatric acute lymphoblastic leukemia. Conclusion: The aggregated data revealed that the rs3731217 variation offers protection against the development of pediatric acute lymphoblastic leukemia and the rs3731249 polymorphism is significantly correlated with susceptibility.http://www.sciencedirect.com/science/article/pii/S2531137924028141Acute lymphoblastic leukemiaPediatricsCDKN2APolymorphism |
| spellingShingle | Maryam Aghasipour Fatemeh Asadian Seyed Alireza Dastgheib Abolhasan Alijanpour Ali Masoudi Maedeh Barahman Mohammad Golshan-Tafti Reza Bahrami Amirmasoud Shiri Hossein Aarafi Kazem Aghili Hossein Neamatzadeh A comprehensive consolidation of data on the connection between CDKN2A polymorphisms and the susceptibility to childhood acute lymphoblastic leukemia Hematology, Transfusion and Cell Therapy Acute lymphoblastic leukemia Pediatrics CDKN2A Polymorphism |
| title | A comprehensive consolidation of data on the connection between CDKN2A polymorphisms and the susceptibility to childhood acute lymphoblastic leukemia |
| title_full | A comprehensive consolidation of data on the connection between CDKN2A polymorphisms and the susceptibility to childhood acute lymphoblastic leukemia |
| title_fullStr | A comprehensive consolidation of data on the connection between CDKN2A polymorphisms and the susceptibility to childhood acute lymphoblastic leukemia |
| title_full_unstemmed | A comprehensive consolidation of data on the connection between CDKN2A polymorphisms and the susceptibility to childhood acute lymphoblastic leukemia |
| title_short | A comprehensive consolidation of data on the connection between CDKN2A polymorphisms and the susceptibility to childhood acute lymphoblastic leukemia |
| title_sort | comprehensive consolidation of data on the connection between cdkn2a polymorphisms and the susceptibility to childhood acute lymphoblastic leukemia |
| topic | Acute lymphoblastic leukemia Pediatrics CDKN2A Polymorphism |
| url | http://www.sciencedirect.com/science/article/pii/S2531137924028141 |
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