Audiomotor Integration in Minimally Conscious State: Proof of Concept!
Patients suffering from chronic disorders of consciousness (DOC) are characterized by profound unawareness and an impairment of large-scale cortical and subcortical connectivity. In this study, we applied an electrophysiological approach aimed at identifying the residual audiomotor connectivity patt...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2015/391349 |
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| _version_ | 1832549664349487104 |
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| author | Antonino Naro Antonino Leo Antonino Cannavò Antonio Buda Rocco Bruno Carlo Salviera Placido Bramanti Rocco Salvatore Calabrò |
| author_facet | Antonino Naro Antonino Leo Antonino Cannavò Antonio Buda Rocco Bruno Carlo Salviera Placido Bramanti Rocco Salvatore Calabrò |
| author_sort | Antonino Naro |
| collection | DOAJ |
| description | Patients suffering from chronic disorders of consciousness (DOC) are characterized by profound unawareness and an impairment of large-scale cortical and subcortical connectivity. In this study, we applied an electrophysiological approach aimed at identifying the residual audiomotor connectivity patterns that are thought to be linked to awareness. We measured some markers of audiomotor integration (AMI) in 20 patients affected by DOC, before and after the application of a repetitive transcranial magnetic stimulation protocol (rTMS) delivered over the left primary motor area (M1), paired to a transauricular alternating current stimulation. Our protocol induced potentiating of the electrophysiological markers of AMI and M1 excitability, paired to a clinical improvement, in all of the patients with minimally conscious state (MCS) but in none of those suffering from unresponsive wakefulness syndrome (UWS). Our protocol could be a promising approach to potentiate the functional connectivity within large-scale audiomotor networks, thus allowing clinicians to differentiate patients affected by MCS from UWS, besides the clinical assessment. |
| format | Article |
| id | doaj-art-822ab37bb95743d491b120ce6f760538 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-822ab37bb95743d491b120ce6f7605382025-02-03T06:10:49ZengWileyNeural Plasticity2090-59041687-54432015-01-01201510.1155/2015/391349391349Audiomotor Integration in Minimally Conscious State: Proof of Concept!Antonino Naro0Antonino Leo1Antonino Cannavò2Antonio Buda3Rocco Bruno4Carlo Salviera5Placido Bramanti6Rocco Salvatore Calabrò7IRCCS Centro Neurolesi “Bonino-Pulejo”, Contrada Casazza, SS113, 98124 Messina, ItalyIRCCS Centro Neurolesi “Bonino-Pulejo”, Contrada Casazza, SS113, 98124 Messina, ItalyIRCCS Centro Neurolesi “Bonino-Pulejo”, Contrada Casazza, SS113, 98124 Messina, ItalyIRCCS Centro Neurolesi “Bonino-Pulejo”, Contrada Casazza, SS113, 98124 Messina, ItalyOtorhinolaryngoiatry Unit, University of Messina, Messina, ItalyOtorhinolaryngoiatry Unit, University of Messina, Messina, ItalyIRCCS Centro Neurolesi “Bonino-Pulejo”, Contrada Casazza, SS113, 98124 Messina, ItalyIRCCS Centro Neurolesi “Bonino-Pulejo”, Contrada Casazza, SS113, 98124 Messina, ItalyPatients suffering from chronic disorders of consciousness (DOC) are characterized by profound unawareness and an impairment of large-scale cortical and subcortical connectivity. In this study, we applied an electrophysiological approach aimed at identifying the residual audiomotor connectivity patterns that are thought to be linked to awareness. We measured some markers of audiomotor integration (AMI) in 20 patients affected by DOC, before and after the application of a repetitive transcranial magnetic stimulation protocol (rTMS) delivered over the left primary motor area (M1), paired to a transauricular alternating current stimulation. Our protocol induced potentiating of the electrophysiological markers of AMI and M1 excitability, paired to a clinical improvement, in all of the patients with minimally conscious state (MCS) but in none of those suffering from unresponsive wakefulness syndrome (UWS). Our protocol could be a promising approach to potentiate the functional connectivity within large-scale audiomotor networks, thus allowing clinicians to differentiate patients affected by MCS from UWS, besides the clinical assessment.http://dx.doi.org/10.1155/2015/391349 |
| spellingShingle | Antonino Naro Antonino Leo Antonino Cannavò Antonio Buda Rocco Bruno Carlo Salviera Placido Bramanti Rocco Salvatore Calabrò Audiomotor Integration in Minimally Conscious State: Proof of Concept! Neural Plasticity |
| title | Audiomotor Integration in Minimally Conscious State: Proof of Concept! |
| title_full | Audiomotor Integration in Minimally Conscious State: Proof of Concept! |
| title_fullStr | Audiomotor Integration in Minimally Conscious State: Proof of Concept! |
| title_full_unstemmed | Audiomotor Integration in Minimally Conscious State: Proof of Concept! |
| title_short | Audiomotor Integration in Minimally Conscious State: Proof of Concept! |
| title_sort | audiomotor integration in minimally conscious state proof of concept |
| url | http://dx.doi.org/10.1155/2015/391349 |
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