COX-2: A Pivotal Enzyme in Mucosal Protection and Resolution of Inflammation
The discovery of a second form of cyclooxygenase, COX-2, led to a burst of research aimed at the development of nonsteroidal anti-inflammatory drugs that would not damage the gastrointestinal tract. In the years since, this promise has only been partially fulfilled. Selective COX-2 inhibitors cause...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2006-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2006.122 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849737945568772096 |
|---|---|
| author | John L. Wallace |
| author_facet | John L. Wallace |
| author_sort | John L. Wallace |
| collection | DOAJ |
| description | The discovery of a second form of cyclooxygenase, COX-2, led to a burst of research aimed at the development of nonsteroidal anti-inflammatory drugs that would not damage the gastrointestinal tract. In the years since, this promise has only been partially fulfilled. Selective COX-2 inhibitors cause less gastric damage than conventional, nonselective COX inhibitors, but their use is still associated with significant gastrointestinal injury, and with toxicity in the renal and cardiovascular systems. COX-2 is now recognized as a source of mediators that produce many beneficial and detrimental effects in the digestive system. In this review, the roles of COX-2 in mucosal defense and injury are discussed. Furthermore, contributions of COX-2derived products to the long-term consequences of intestinal inflammation, including cancer, are reviewed. |
| format | Article |
| id | doaj-art-8229b40b4cbf45a0aa9f6453a4ef229c |
| institution | DOAJ |
| issn | 1537-744X |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-8229b40b4cbf45a0aa9f6453a4ef229c2025-08-20T03:06:46ZengWileyThe Scientific World Journal1537-744X2006-01-01657758810.1100/tsw.2006.122COX-2: A Pivotal Enzyme in Mucosal Protection and Resolution of InflammationJohn L. Wallace0Inflammation Research Network, Department of Pharmacology and Therapeutics, University of Calgary, Calgary, Alberta, T2N 4N1, CanadaThe discovery of a second form of cyclooxygenase, COX-2, led to a burst of research aimed at the development of nonsteroidal anti-inflammatory drugs that would not damage the gastrointestinal tract. In the years since, this promise has only been partially fulfilled. Selective COX-2 inhibitors cause less gastric damage than conventional, nonselective COX inhibitors, but their use is still associated with significant gastrointestinal injury, and with toxicity in the renal and cardiovascular systems. COX-2 is now recognized as a source of mediators that produce many beneficial and detrimental effects in the digestive system. In this review, the roles of COX-2 in mucosal defense and injury are discussed. Furthermore, contributions of COX-2derived products to the long-term consequences of intestinal inflammation, including cancer, are reviewed.http://dx.doi.org/10.1100/tsw.2006.122 |
| spellingShingle | John L. Wallace COX-2: A Pivotal Enzyme in Mucosal Protection and Resolution of Inflammation The Scientific World Journal |
| title | COX-2: A Pivotal Enzyme in Mucosal Protection and Resolution of Inflammation |
| title_full | COX-2: A Pivotal Enzyme in Mucosal Protection and Resolution of Inflammation |
| title_fullStr | COX-2: A Pivotal Enzyme in Mucosal Protection and Resolution of Inflammation |
| title_full_unstemmed | COX-2: A Pivotal Enzyme in Mucosal Protection and Resolution of Inflammation |
| title_short | COX-2: A Pivotal Enzyme in Mucosal Protection and Resolution of Inflammation |
| title_sort | cox 2 a pivotal enzyme in mucosal protection and resolution of inflammation |
| url | http://dx.doi.org/10.1100/tsw.2006.122 |
| work_keys_str_mv | AT johnlwallace cox2apivotalenzymeinmucosalprotectionandresolutionofinflammation |