Effectiveness of home-based exercise combined with nutritional care intervention in elderly patients with gastric cancer and sarcopenia: a retrospective study
BackgroundSarcopenia and malnutrition are prevalent among elderly patients with gastric cancer, significantly impairing recovery and quality of life (QoL). Effective interventions targeting both nutritional and physical deficiencies are critical. This study evaluated the effectiveness of a home-base...
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Frontiers Media S.A.
2025-05-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1544689/full |
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| author | Chun-Jing Yang Chun-Jing Yang Li Chen Li Chen Li Chen Qing Zhou Qing Zhou Hui Hou Hui Hou Feng-Yi Xie Feng-Yi Xie |
| author_facet | Chun-Jing Yang Chun-Jing Yang Li Chen Li Chen Li Chen Qing Zhou Qing Zhou Hui Hou Hui Hou Feng-Yi Xie Feng-Yi Xie |
| author_sort | Chun-Jing Yang |
| collection | DOAJ |
| description | BackgroundSarcopenia and malnutrition are prevalent among elderly patients with gastric cancer, significantly impairing recovery and quality of life (QoL). Effective interventions targeting both nutritional and physical deficiencies are critical. This study evaluated the effectiveness of a home-based exercise combined with nutritional care intervention in improving nutritional status, patient-generated subjective global assessment (PG-SGA) scores, and QoL among elderly patients with gastric cancer and sarcopenia.MethodsA retrospective evaluation was conducted on 126 elderly patients (aged ≥ 65 years) with gastric cancer and sarcopenia between January 2021 and December 2023. Patients were divided into two groups: the observation group (n = 61) received a home-based exercise combined with nutritional care intervention, while the control group (n = 65) received standard oncological nursing care. Nutritional status was assessed using biomarkers (albumin, prealbumin, transferrin) and PG-SGA scores, while QoL was measured using the Generic Quality of Life Inventory-74 (GQOLI-74). Data was analyzed using independent t-tests and Chi-square tests, with p < 0.05 considered statistically significant.ResultsBaseline characteristics were comparable between the groups (P > 0.05). Following the intervention, the observation group exhibited significantly greater improvements in nutritional biomarkers compared to the control group: albumin (41.80 ± 5.45 g/L vs. 32.25 ± 5.37 g/L, t = 9.905, P < 0.001), prealbumin (288.59 ± 25.95 mg/L vs. 219.20 ± 23.05 mg/L, t = 15.89, P < 0.001), and transferrin (2.28 ± 0.28 g/L vs. 1.77 ± 0.23 g/L, t = 11.20, P < 0.001). The observation group’s PG-SGA scores decreased significantly (1.28 ± 0.28 vs. 4.33 ± 0.56 in the control group, t = 38.28, P < 0.001). QoL scores in physical, psychological, social, and material life domains also showed substantial improvements in the observation group compared to the control group (P < 0.001 for all).ConclusionThe home-based exercise combined with nutritional care intervention significantly enhanced nutritional status, reduced PG-SGA scores, and improved QoL in elderly patients with gastric cancer and sarcopenia. This integrated approach demonstrates its value as an effective strategy for comprehensive cancer care, addressing both physical and nutritional deficits to optimize recovery outcomes. |
| format | Article |
| id | doaj-art-82290820688f4b68bbb0f355e6136c2d |
| institution | OA Journals |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
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| spelling | doaj-art-82290820688f4b68bbb0f355e6136c2d2025-08-20T02:25:35ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-05-011210.3389/fmed.2025.15446891544689Effectiveness of home-based exercise combined with nutritional care intervention in elderly patients with gastric cancer and sarcopenia: a retrospective studyChun-Jing Yang0Chun-Jing Yang1Li Chen2Li Chen3Li Chen4Qing Zhou5Qing Zhou6Hui Hou7Hui Hou8Feng-Yi Xie9Feng-Yi Xie10Gastric Cancer Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, ChinaChinese Hospital Reform and Development Institute, Nanjing University, Nanjing, Jiangsu, ChinaGastric Cancer Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, ChinaChinese Hospital Reform and Development Institute, Nanjing University, Nanjing, Jiangsu, ChinaJiangsu Provincial People’s Hospital, Nanjing, Jiangsu, ChinaGastric Cancer Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, ChinaChinese Hospital Reform and Development Institute, Nanjing University, Nanjing, Jiangsu, ChinaGastric Cancer Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, ChinaChinese Hospital Reform and Development Institute, Nanjing University, Nanjing, Jiangsu, ChinaGastric Cancer Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, ChinaChinese Hospital Reform and Development Institute, Nanjing University, Nanjing, Jiangsu, ChinaBackgroundSarcopenia and malnutrition are prevalent among elderly patients with gastric cancer, significantly impairing recovery and quality of life (QoL). Effective interventions targeting both nutritional and physical deficiencies are critical. This study evaluated the effectiveness of a home-based exercise combined with nutritional care intervention in improving nutritional status, patient-generated subjective global assessment (PG-SGA) scores, and QoL among elderly patients with gastric cancer and sarcopenia.MethodsA retrospective evaluation was conducted on 126 elderly patients (aged ≥ 65 years) with gastric cancer and sarcopenia between January 2021 and December 2023. Patients were divided into two groups: the observation group (n = 61) received a home-based exercise combined with nutritional care intervention, while the control group (n = 65) received standard oncological nursing care. Nutritional status was assessed using biomarkers (albumin, prealbumin, transferrin) and PG-SGA scores, while QoL was measured using the Generic Quality of Life Inventory-74 (GQOLI-74). Data was analyzed using independent t-tests and Chi-square tests, with p < 0.05 considered statistically significant.ResultsBaseline characteristics were comparable between the groups (P > 0.05). Following the intervention, the observation group exhibited significantly greater improvements in nutritional biomarkers compared to the control group: albumin (41.80 ± 5.45 g/L vs. 32.25 ± 5.37 g/L, t = 9.905, P < 0.001), prealbumin (288.59 ± 25.95 mg/L vs. 219.20 ± 23.05 mg/L, t = 15.89, P < 0.001), and transferrin (2.28 ± 0.28 g/L vs. 1.77 ± 0.23 g/L, t = 11.20, P < 0.001). The observation group’s PG-SGA scores decreased significantly (1.28 ± 0.28 vs. 4.33 ± 0.56 in the control group, t = 38.28, P < 0.001). QoL scores in physical, psychological, social, and material life domains also showed substantial improvements in the observation group compared to the control group (P < 0.001 for all).ConclusionThe home-based exercise combined with nutritional care intervention significantly enhanced nutritional status, reduced PG-SGA scores, and improved QoL in elderly patients with gastric cancer and sarcopenia. This integrated approach demonstrates its value as an effective strategy for comprehensive cancer care, addressing both physical and nutritional deficits to optimize recovery outcomes.https://www.frontiersin.org/articles/10.3389/fmed.2025.1544689/fullgastric cancersarcopeniahome-based exercisenutritional carequality of lifenutritional biomarkers |
| spellingShingle | Chun-Jing Yang Chun-Jing Yang Li Chen Li Chen Li Chen Qing Zhou Qing Zhou Hui Hou Hui Hou Feng-Yi Xie Feng-Yi Xie Effectiveness of home-based exercise combined with nutritional care intervention in elderly patients with gastric cancer and sarcopenia: a retrospective study Frontiers in Medicine gastric cancer sarcopenia home-based exercise nutritional care quality of life nutritional biomarkers |
| title | Effectiveness of home-based exercise combined with nutritional care intervention in elderly patients with gastric cancer and sarcopenia: a retrospective study |
| title_full | Effectiveness of home-based exercise combined with nutritional care intervention in elderly patients with gastric cancer and sarcopenia: a retrospective study |
| title_fullStr | Effectiveness of home-based exercise combined with nutritional care intervention in elderly patients with gastric cancer and sarcopenia: a retrospective study |
| title_full_unstemmed | Effectiveness of home-based exercise combined with nutritional care intervention in elderly patients with gastric cancer and sarcopenia: a retrospective study |
| title_short | Effectiveness of home-based exercise combined with nutritional care intervention in elderly patients with gastric cancer and sarcopenia: a retrospective study |
| title_sort | effectiveness of home based exercise combined with nutritional care intervention in elderly patients with gastric cancer and sarcopenia a retrospective study |
| topic | gastric cancer sarcopenia home-based exercise nutritional care quality of life nutritional biomarkers |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1544689/full |
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