Case report: A rollercoaster journey of pemphigus vegetans
Pemphigus vegetans (P Veg), the rarest subtype of pemphigus, is characterized by vegetative plaques, primarily affecting intertriginous areas. The most common autoantibodies target desmoglein 3 (Dsg3). A 60-year-old female patient presented with well-demarcated red vegetative plaques on her feet, vu...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1481192/full |
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| author | Xiaoyuan Hou Jia Chen |
| author_facet | Xiaoyuan Hou Jia Chen |
| author_sort | Xiaoyuan Hou |
| collection | DOAJ |
| description | Pemphigus vegetans (P Veg), the rarest subtype of pemphigus, is characterized by vegetative plaques, primarily affecting intertriginous areas. The most common autoantibodies target desmoglein 3 (Dsg3). A 60-year-old female patient presented with well-demarcated red vegetative plaques on her feet, vulva, and thigh, accompanied by surrounding pustules. Histopathological examination revealed epidermal hyperplasia with significant infiltration of neutrophils and eosinophils in the dermis. Enzyme-linked immunosorbent assay showed elevated anti-Dsg3 antibodies (203.2 U/ml), and immunohistochemical staining confirmed positive expression of anti-Dsg3 IgG antibodies in keratinocytes. The patient was diagnosed with P Veg and achieved remission after treatment with either 900 mg of intravenous spesolimab or oral methylprednisolone. |
| format | Article |
| id | doaj-art-8226f10f746747b1aaab39f4d9cb6369 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-8226f10f746747b1aaab39f4d9cb63692025-01-13T05:10:43ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.14811921481192Case report: A rollercoaster journey of pemphigus vegetansXiaoyuan HouJia ChenPemphigus vegetans (P Veg), the rarest subtype of pemphigus, is characterized by vegetative plaques, primarily affecting intertriginous areas. The most common autoantibodies target desmoglein 3 (Dsg3). A 60-year-old female patient presented with well-demarcated red vegetative plaques on her feet, vulva, and thigh, accompanied by surrounding pustules. Histopathological examination revealed epidermal hyperplasia with significant infiltration of neutrophils and eosinophils in the dermis. Enzyme-linked immunosorbent assay showed elevated anti-Dsg3 antibodies (203.2 U/ml), and immunohistochemical staining confirmed positive expression of anti-Dsg3 IgG antibodies in keratinocytes. The patient was diagnosed with P Veg and achieved remission after treatment with either 900 mg of intravenous spesolimab or oral methylprednisolone.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1481192/fullimmunobullous diseasepemphigus vegetansIL-36 receptor antagonistspesolimabhistopathology |
| spellingShingle | Xiaoyuan Hou Jia Chen Case report: A rollercoaster journey of pemphigus vegetans Frontiers in Immunology immunobullous disease pemphigus vegetans IL-36 receptor antagonist spesolimab histopathology |
| title | Case report: A rollercoaster journey of pemphigus vegetans |
| title_full | Case report: A rollercoaster journey of pemphigus vegetans |
| title_fullStr | Case report: A rollercoaster journey of pemphigus vegetans |
| title_full_unstemmed | Case report: A rollercoaster journey of pemphigus vegetans |
| title_short | Case report: A rollercoaster journey of pemphigus vegetans |
| title_sort | case report a rollercoaster journey of pemphigus vegetans |
| topic | immunobullous disease pemphigus vegetans IL-36 receptor antagonist spesolimab histopathology |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1481192/full |
| work_keys_str_mv | AT xiaoyuanhou casereportarollercoasterjourneyofpemphigusvegetans AT jiachen casereportarollercoasterjourneyofpemphigusvegetans |