Biomarkers of sepsis-induced coagulopathy: diagnostic insights and potential therapeutic implications
Abstract Diagnosing coagulopathy in septic patients remains challenging in intensive care. Disseminated intravascular coagulation (DIC) indeed presents with complex pathophysiology, complicating timely diagnosis. Epidemiological data indicate a significant prevalence of DIC in septic patients, with...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-01-01
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| Series: | Annals of Intensive Care |
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| Online Access: | https://doi.org/10.1186/s13613-025-01434-2 |
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| _version_ | 1832594418274664448 |
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| author | Anaïs Curtiaud Toshiaki Iba Eduardo Angles-Cano Ferhat Meziani Julie Helms |
| author_facet | Anaïs Curtiaud Toshiaki Iba Eduardo Angles-Cano Ferhat Meziani Julie Helms |
| author_sort | Anaïs Curtiaud |
| collection | DOAJ |
| description | Abstract Diagnosing coagulopathy in septic patients remains challenging in intensive care. Disseminated intravascular coagulation (DIC) indeed presents with complex pathophysiology, complicating timely diagnosis. Epidemiological data indicate a significant prevalence of DIC in septic patients, with mortality rates up to 60%. Despite advances, current biomarker-based diagnostic tools often fail to provide early and accurate detection. This review evaluates the utility and limitations of traditional and emerging biomarkers for diagnosing sepsis-induced coagulopathy (SIC) and DIC. We also assess the effectiveness of anticoagulant therapy guided by biomarker-based diagnostic criteria. |
| format | Article |
| id | doaj-art-8226dd81273947f194c40ccc1db66e97 |
| institution | Kabale University |
| issn | 2110-5820 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Annals of Intensive Care |
| spelling | doaj-art-8226dd81273947f194c40ccc1db66e972025-01-19T12:38:34ZengSpringerOpenAnnals of Intensive Care2110-58202025-01-0115111010.1186/s13613-025-01434-2Biomarkers of sepsis-induced coagulopathy: diagnostic insights and potential therapeutic implicationsAnaïs Curtiaud0Toshiaki Iba1Eduardo Angles-Cano2Ferhat Meziani3Julie Helms4Faculté de Médecine, Service de Médecine Intensive-Réanimation, Université de Strasbourg (UNISTRA), Hôpitaux universitaires de Strasbourg, Nouvel Hôpital CivilDepartment of Emergency and Disaster Medicine, Juntendo University Graduate School of MedicineInnovative Therapies in Haemostasis, Université Paris Cité - INSERM U-1140Faculté de Médecine, Service de Médecine Intensive-Réanimation, Université de Strasbourg (UNISTRA), Hôpitaux universitaires de Strasbourg, Nouvel Hôpital CivilFaculté de Médecine, Service de Médecine Intensive-Réanimation, Université de Strasbourg (UNISTRA), Hôpitaux universitaires de Strasbourg, Nouvel Hôpital CivilAbstract Diagnosing coagulopathy in septic patients remains challenging in intensive care. Disseminated intravascular coagulation (DIC) indeed presents with complex pathophysiology, complicating timely diagnosis. Epidemiological data indicate a significant prevalence of DIC in septic patients, with mortality rates up to 60%. Despite advances, current biomarker-based diagnostic tools often fail to provide early and accurate detection. This review evaluates the utility and limitations of traditional and emerging biomarkers for diagnosing sepsis-induced coagulopathy (SIC) and DIC. We also assess the effectiveness of anticoagulant therapy guided by biomarker-based diagnostic criteria.https://doi.org/10.1186/s13613-025-01434-2Disseminated intravascular coagulationCoagulopathySepsisSeptic shock |
| spellingShingle | Anaïs Curtiaud Toshiaki Iba Eduardo Angles-Cano Ferhat Meziani Julie Helms Biomarkers of sepsis-induced coagulopathy: diagnostic insights and potential therapeutic implications Annals of Intensive Care Disseminated intravascular coagulation Coagulopathy Sepsis Septic shock |
| title | Biomarkers of sepsis-induced coagulopathy: diagnostic insights and potential therapeutic implications |
| title_full | Biomarkers of sepsis-induced coagulopathy: diagnostic insights and potential therapeutic implications |
| title_fullStr | Biomarkers of sepsis-induced coagulopathy: diagnostic insights and potential therapeutic implications |
| title_full_unstemmed | Biomarkers of sepsis-induced coagulopathy: diagnostic insights and potential therapeutic implications |
| title_short | Biomarkers of sepsis-induced coagulopathy: diagnostic insights and potential therapeutic implications |
| title_sort | biomarkers of sepsis induced coagulopathy diagnostic insights and potential therapeutic implications |
| topic | Disseminated intravascular coagulation Coagulopathy Sepsis Septic shock |
| url | https://doi.org/10.1186/s13613-025-01434-2 |
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