Ceramide as a Promising Tool for Diagnosis and Treatment of Clinical Diseases: A Review of Recent Advances
<b>Background/Objectives:</b> Ceramide, a sphingolipid metabolite, has emerged as a key player in various physiological and pathological processes. Changes in ceramide levels are associated with the occurrence and development of various diseases, highlighting its potential as a biomarker...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-03-01
|
| Series: | Metabolites |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-1989/15/3/195 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850279393006452736 |
|---|---|
| author | Xueping Shen Rui Feng Rui Zhou Zhaoyang Zhang Kaiyong Liu Sheng Wang |
| author_facet | Xueping Shen Rui Feng Rui Zhou Zhaoyang Zhang Kaiyong Liu Sheng Wang |
| author_sort | Xueping Shen |
| collection | DOAJ |
| description | <b>Background/Objectives:</b> Ceramide, a sphingolipid metabolite, has emerged as a key player in various physiological and pathological processes. Changes in ceramide levels are associated with the occurrence and development of various diseases, highlighting its potential as a biomarker of various clinical diseases. <b>Methods:</b> The biosynthesis and metabolism of ceramide are discussed, along with its functions in cell signaling, apoptosis, and inflammation. This study further examines the potential of ceramide as a biomarker for disease diagnosis and treatment. <b>Results:</b> This article highlights the involvement of ceramide in several diseases, including cardiovascular diseases, dermatosis, cancer, neurodegenerative disorders and metabolic syndromes. For each disease, the potential of ceramide as a biomarker for disease diagnosis and prognosis is explored, and the feasibility of therapeutic strategies targeting ceramide metabolism are reviewed. Additionally, the challenges and future directions in the field of ceramide research are addressed. <b>Conclusions:</b> This review article provides an overview of the recent advances in understanding the role of ceramide in clinical diseases and its potential as a diagnostic and therapeutic tool. |
| format | Article |
| id | doaj-art-8215bbc9b60e42a4b3a5ccd71982c5b0 |
| institution | OA Journals |
| issn | 2218-1989 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj-art-8215bbc9b60e42a4b3a5ccd71982c5b02025-08-20T01:49:05ZengMDPI AGMetabolites2218-19892025-03-0115319510.3390/metabo15030195Ceramide as a Promising Tool for Diagnosis and Treatment of Clinical Diseases: A Review of Recent AdvancesXueping Shen0Rui Feng1Rui Zhou2Zhaoyang Zhang3Kaiyong Liu4Sheng Wang5School of Stomatology, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, ChinaInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Center for Scientific Research, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, ChinaSchool of Pharmacy, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, ChinaInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Center for Scientific Research, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, ChinaSchool of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei 230032, ChinaInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Center for Scientific Research, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, China<b>Background/Objectives:</b> Ceramide, a sphingolipid metabolite, has emerged as a key player in various physiological and pathological processes. Changes in ceramide levels are associated with the occurrence and development of various diseases, highlighting its potential as a biomarker of various clinical diseases. <b>Methods:</b> The biosynthesis and metabolism of ceramide are discussed, along with its functions in cell signaling, apoptosis, and inflammation. This study further examines the potential of ceramide as a biomarker for disease diagnosis and treatment. <b>Results:</b> This article highlights the involvement of ceramide in several diseases, including cardiovascular diseases, dermatosis, cancer, neurodegenerative disorders and metabolic syndromes. For each disease, the potential of ceramide as a biomarker for disease diagnosis and prognosis is explored, and the feasibility of therapeutic strategies targeting ceramide metabolism are reviewed. Additionally, the challenges and future directions in the field of ceramide research are addressed. <b>Conclusions:</b> This review article provides an overview of the recent advances in understanding the role of ceramide in clinical diseases and its potential as a diagnostic and therapeutic tool.https://www.mdpi.com/2218-1989/15/3/195ceramidescardiovascular diseasecancerdermatosisAlzheimer’s diseaseobesity |
| spellingShingle | Xueping Shen Rui Feng Rui Zhou Zhaoyang Zhang Kaiyong Liu Sheng Wang Ceramide as a Promising Tool for Diagnosis and Treatment of Clinical Diseases: A Review of Recent Advances Metabolites ceramides cardiovascular disease cancer dermatosis Alzheimer’s disease obesity |
| title | Ceramide as a Promising Tool for Diagnosis and Treatment of Clinical Diseases: A Review of Recent Advances |
| title_full | Ceramide as a Promising Tool for Diagnosis and Treatment of Clinical Diseases: A Review of Recent Advances |
| title_fullStr | Ceramide as a Promising Tool for Diagnosis and Treatment of Clinical Diseases: A Review of Recent Advances |
| title_full_unstemmed | Ceramide as a Promising Tool for Diagnosis and Treatment of Clinical Diseases: A Review of Recent Advances |
| title_short | Ceramide as a Promising Tool for Diagnosis and Treatment of Clinical Diseases: A Review of Recent Advances |
| title_sort | ceramide as a promising tool for diagnosis and treatment of clinical diseases a review of recent advances |
| topic | ceramides cardiovascular disease cancer dermatosis Alzheimer’s disease obesity |
| url | https://www.mdpi.com/2218-1989/15/3/195 |
| work_keys_str_mv | AT xuepingshen ceramideasapromisingtoolfordiagnosisandtreatmentofclinicaldiseasesareviewofrecentadvances AT ruifeng ceramideasapromisingtoolfordiagnosisandtreatmentofclinicaldiseasesareviewofrecentadvances AT ruizhou ceramideasapromisingtoolfordiagnosisandtreatmentofclinicaldiseasesareviewofrecentadvances AT zhaoyangzhang ceramideasapromisingtoolfordiagnosisandtreatmentofclinicaldiseasesareviewofrecentadvances AT kaiyongliu ceramideasapromisingtoolfordiagnosisandtreatmentofclinicaldiseasesareviewofrecentadvances AT shengwang ceramideasapromisingtoolfordiagnosisandtreatmentofclinicaldiseasesareviewofrecentadvances |