Effect of Moderate-Intensity Exercise on Plasma C-Reactive Protein and Aortic Endothelial Function in Type 2 Diabetic Mice
The aim of this study was to evaluate the effects of moderate-intensity exercise on plasma levels of C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-α) as markers of low-grade inflammation and endothelial function in diabetic (db/db) mice. Control and db/db mice were...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2010/149678 |
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| author | Nada Sallam Majid Khazaei Ismail Laher |
| author_facet | Nada Sallam Majid Khazaei Ismail Laher |
| author_sort | Nada Sallam |
| collection | DOAJ |
| description | The aim of this study was to evaluate the effects of moderate-intensity exercise on plasma levels of C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-α) as markers of low-grade inflammation and endothelial function in diabetic (db/db) mice. Control and
db/db mice were divided into sedentary and exercised groups. Aortic endothelial function was evaluated after two- and six-week exercises using a wire myograph. Plasma CRP levels were measured at baseline, and after two and six weeks of exercise. Baseline plasma CRP levels were significantly higher in db/db mice compared to control (P<.05). After two weeks of exercise, aortic endothelial function was significantly improved without affecting body weight or plasma CRP levels. Six weeks of exercise not only improved endothelial function, but also significantly reduced body weight and plasma CRP levels in db/db mice. Thus short-term exercise has beneficial effect on endothelial function without reducing low-grade inflammation while more prolonged exercise periods are required to reduce inflammatory markers. |
| format | Article |
| id | doaj-art-8214dd60f65c48238699aff56ee2e170 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-8214dd60f65c48238699aff56ee2e1702025-08-20T03:35:25ZengWileyMediators of Inflammation0962-93511466-18612010-01-01201010.1155/2010/149678149678Effect of Moderate-Intensity Exercise on Plasma C-Reactive Protein and Aortic Endothelial Function in Type 2 Diabetic MiceNada Sallam0Majid Khazaei1Ismail Laher2Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, BC, V6T 1Z4, CanadaDepartment of Physiology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, BC, V6T 1Z4, CanadaThe aim of this study was to evaluate the effects of moderate-intensity exercise on plasma levels of C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-α) as markers of low-grade inflammation and endothelial function in diabetic (db/db) mice. Control and db/db mice were divided into sedentary and exercised groups. Aortic endothelial function was evaluated after two- and six-week exercises using a wire myograph. Plasma CRP levels were measured at baseline, and after two and six weeks of exercise. Baseline plasma CRP levels were significantly higher in db/db mice compared to control (P<.05). After two weeks of exercise, aortic endothelial function was significantly improved without affecting body weight or plasma CRP levels. Six weeks of exercise not only improved endothelial function, but also significantly reduced body weight and plasma CRP levels in db/db mice. Thus short-term exercise has beneficial effect on endothelial function without reducing low-grade inflammation while more prolonged exercise periods are required to reduce inflammatory markers.http://dx.doi.org/10.1155/2010/149678 |
| spellingShingle | Nada Sallam Majid Khazaei Ismail Laher Effect of Moderate-Intensity Exercise on Plasma C-Reactive Protein and Aortic Endothelial Function in Type 2 Diabetic Mice Mediators of Inflammation |
| title | Effect of Moderate-Intensity Exercise on Plasma C-Reactive Protein and Aortic Endothelial Function in Type 2 Diabetic Mice |
| title_full | Effect of Moderate-Intensity Exercise on Plasma C-Reactive Protein and Aortic Endothelial Function in Type 2 Diabetic Mice |
| title_fullStr | Effect of Moderate-Intensity Exercise on Plasma C-Reactive Protein and Aortic Endothelial Function in Type 2 Diabetic Mice |
| title_full_unstemmed | Effect of Moderate-Intensity Exercise on Plasma C-Reactive Protein and Aortic Endothelial Function in Type 2 Diabetic Mice |
| title_short | Effect of Moderate-Intensity Exercise on Plasma C-Reactive Protein and Aortic Endothelial Function in Type 2 Diabetic Mice |
| title_sort | effect of moderate intensity exercise on plasma c reactive protein and aortic endothelial function in type 2 diabetic mice |
| url | http://dx.doi.org/10.1155/2010/149678 |
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