Breaking boundaries in ankylosing spondylitis: how innovative cell therapies reshape immunity, drive cutting-edge advances, and face future challenges

Breaking boundaries in ankylosing spondylitis: how innovative cell therapies reshape immunity, drive cutting-edge advances, and face future challenges

Ankylosing spondylitis (AS) is a chronic autoimmune inflammatory disease primarily affecting the axial skeleton, characterized by joint erosion and ankylosis. AS significantly impacts quality of life, work capacity and mental health through chronic pain, stiffness and functional decline. Its pathoge...

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Bibliographic Details
Main Authors: Minxia Ke, Wenli Liu, Huimin Lu, Xiafei Pan, Mengyang Wu, Nianmin Qi, Zhiqiang Wang, Yuehong Wu, Feng Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
ankylosing spondylitis
mesenchymal stem cells
regenerative medicine
chimeric antigen receptor T-cell therapy
clinical progress
autoimmune inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1613502/full
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