Effects of sodium bicarbonate therapy on cognitive and cerebrovascular function in midlife and older adults with chronic kidney disease: a pilot randomized trial

Effects of sodium bicarbonate therapy on cognitive and cerebrovascular function in midlife and older adults with chronic kidney disease: a pilot randomized trial

Abstract Introduction Metabolic acidosis may create a pathway to cognitive impairment in chronic kidney disease (CKD) by contributing to cerebrovascular dysfunction. Trials examining the effect of sodium bicarbonate (NaHCO3) on cognitive function are lacking. Methods We conducted a randomized, doubl...

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Bibliographic Details
Main Authors: Fangning Gu, Zhiying You, Nell Hawkins, Rachael Reddin, Rahaf Hamour, Allison Shapiro, Christina Coughlan, Douglas Seals, Seth Furgeson, Angelina Dixon, Kristen L. Nowak, Jessica Kendrick
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Nephrology
Subjects:
Cognition
Sodium bicarbonate
Chronic kidney disease
Metabolic acidosis
Online Access:https://doi.org/10.1186/s12882-025-04388-6
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