Pros and Cons of the SeHCAT Test in Bile Acid Diarrhea: A More Appropriate Use of an Old Nuclear Medicine Technique
Bile acid malabsorption (BAM) causing chronic diarrhea may be due to organic as well as functional disorders, and some of them were included under the general label of diarrheic-type irritable bowel syndrome (IBS-D). The 75-selenium homocholic acid taurine (SeHCAT) test is a nuclear medicine investi...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2018/2097359 |
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| author | Bernardo Fani Lorenzo Bertani Italia Paglianiti Lorenzo Fantechi Nicola De Bortoli Francesco Costa Duccio Volterrani Santino Marchi Massimo Bellini |
| author_facet | Bernardo Fani Lorenzo Bertani Italia Paglianiti Lorenzo Fantechi Nicola De Bortoli Francesco Costa Duccio Volterrani Santino Marchi Massimo Bellini |
| author_sort | Bernardo Fani |
| collection | DOAJ |
| description | Bile acid malabsorption (BAM) causing chronic diarrhea may be due to organic as well as functional disorders, and some of them were included under the general label of diarrheic-type irritable bowel syndrome (IBS-D). The 75-selenium homocholic acid taurine (SeHCAT) test is a nuclear medicine investigation considered to be the gold standard for the diagnosis of bile acid malabsorption (BAM). Many studies demonstrate that it could be effective in the clinical workout of chronic diarrhea due to different conditions. The SeHCAT test provides a quantitative assessment to estimate the severity of BAM and the possible response to therapy with bile acid sequestrants (BASs). However, there is no general agreement regarding its cutoff value and the test is not widely available. The aim of this review is to discuss the advantages and disadvantages of the SeHCAT test in clinical practice. |
| format | Article |
| id | doaj-art-8207d04fb163481082dc44a2353bd668 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-8207d04fb163481082dc44a2353bd6682025-02-03T05:54:01ZengWileyGastroenterology Research and Practice1687-61211687-630X2018-01-01201810.1155/2018/20973592097359Pros and Cons of the SeHCAT Test in Bile Acid Diarrhea: A More Appropriate Use of an Old Nuclear Medicine TechniqueBernardo Fani0Lorenzo Bertani1Italia Paglianiti2Lorenzo Fantechi3Nicola De Bortoli4Francesco Costa5Duccio Volterrani6Santino Marchi7Massimo Bellini8Department of New Technologies and Translational Research in Medicine and Surgery, Gastroenterology Unit, University of Pisa, Via Roma 67, 56122 Pisa, ItalyDepartment of New Technologies and Translational Research in Medicine and Surgery, Gastroenterology Unit, University of Pisa, Via Roma 67, 56122 Pisa, ItalyDepartment of New Technologies and Translational Research in Medicine and Surgery, Nuclear Medicine Unit, University of Pisa, Via Roma 67, 56122 Pisa, ItalyDepartment of New Technologies and Translational Research in Medicine and Surgery, Nuclear Medicine Unit, University of Pisa, Via Roma 67, 56122 Pisa, ItalyDepartment of New Technologies and Translational Research in Medicine and Surgery, Gastroenterology Unit, University of Pisa, Via Roma 67, 56122 Pisa, ItalyDepartment of General Surgery and Gastroenterology, Gastroenterology Unit, Az. Ospedaliero Universitaria Pisana, Via Paradisa 2, 56124 Pisa, ItalyDepartment of New Technologies and Translational Research in Medicine and Surgery, Nuclear Medicine Unit, University of Pisa, Via Roma 67, 56122 Pisa, ItalyDepartment of New Technologies and Translational Research in Medicine and Surgery, Gastroenterology Unit, University of Pisa, Via Roma 67, 56122 Pisa, ItalyDepartment of New Technologies and Translational Research in Medicine and Surgery, Gastroenterology Unit, University of Pisa, Via Roma 67, 56122 Pisa, ItalyBile acid malabsorption (BAM) causing chronic diarrhea may be due to organic as well as functional disorders, and some of them were included under the general label of diarrheic-type irritable bowel syndrome (IBS-D). The 75-selenium homocholic acid taurine (SeHCAT) test is a nuclear medicine investigation considered to be the gold standard for the diagnosis of bile acid malabsorption (BAM). Many studies demonstrate that it could be effective in the clinical workout of chronic diarrhea due to different conditions. The SeHCAT test provides a quantitative assessment to estimate the severity of BAM and the possible response to therapy with bile acid sequestrants (BASs). However, there is no general agreement regarding its cutoff value and the test is not widely available. The aim of this review is to discuss the advantages and disadvantages of the SeHCAT test in clinical practice.http://dx.doi.org/10.1155/2018/2097359 |
| spellingShingle | Bernardo Fani Lorenzo Bertani Italia Paglianiti Lorenzo Fantechi Nicola De Bortoli Francesco Costa Duccio Volterrani Santino Marchi Massimo Bellini Pros and Cons of the SeHCAT Test in Bile Acid Diarrhea: A More Appropriate Use of an Old Nuclear Medicine Technique Gastroenterology Research and Practice |
| title | Pros and Cons of the SeHCAT Test in Bile Acid Diarrhea: A More Appropriate Use of an Old Nuclear Medicine Technique |
| title_full | Pros and Cons of the SeHCAT Test in Bile Acid Diarrhea: A More Appropriate Use of an Old Nuclear Medicine Technique |
| title_fullStr | Pros and Cons of the SeHCAT Test in Bile Acid Diarrhea: A More Appropriate Use of an Old Nuclear Medicine Technique |
| title_full_unstemmed | Pros and Cons of the SeHCAT Test in Bile Acid Diarrhea: A More Appropriate Use of an Old Nuclear Medicine Technique |
| title_short | Pros and Cons of the SeHCAT Test in Bile Acid Diarrhea: A More Appropriate Use of an Old Nuclear Medicine Technique |
| title_sort | pros and cons of the sehcat test in bile acid diarrhea a more appropriate use of an old nuclear medicine technique |
| url | http://dx.doi.org/10.1155/2018/2097359 |
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