FKBP10 expression and TP53 mutation predict prognosis and chemotherapy response in triple-negative breast cancer
Abstract Background Triple-negative breast cancer (TNBC) lacks targeted therapies. FKBP10 contributes to oncogenesis and chemoresistance. We investigated FKBP10’s prognostic value in TNBC. Methods We retrospectively analyzed 190 TNBC patients receiving neoadjuvant chemotherapy. Patients were stratif...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer
2025-07-01
|
| Series: | Discover Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s12672-025-03275-8 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849332251373862912 |
|---|---|
| author | Yan Li Chi Zhang Jian Chen Gang Tu Lingfeng Tang |
| author_facet | Yan Li Chi Zhang Jian Chen Gang Tu Lingfeng Tang |
| author_sort | Yan Li |
| collection | DOAJ |
| description | Abstract Background Triple-negative breast cancer (TNBC) lacks targeted therapies. FKBP10 contributes to oncogenesis and chemoresistance. We investigated FKBP10’s prognostic value in TNBC. Methods We retrospectively analyzed 190 TNBC patients receiving neoadjuvant chemotherapy. Patients were stratified by FKBP10 expression (median AOD cutoff) and TP53 status. Cox regression identified prognostic factors for disease-free survival (DFS) and pathological complete response (pCR). Results 34% achieved pCR. High FKBP10 expression correlated with worse DFS (HR = 0.50, 95%CI: 0.26–0.96, P = 0.03). Independent predictors of DFS included: N-stage (P = 0.021), age (P = 0.027), FKBP10/TP53 co-occurrence (P = 0.020), and pCR status (P = 0.005). FKBP10/TP53 co-occurrence predicted poor chemotherapy response (OR = 0.413, P = 0.016). Conclusion FKBP10 overexpression with TP53 mutation predicts poor prognosis and chemoresistance in TNBC. These biomarkers may guide treatment decisions, though prospective validation is needed. |
| format | Article |
| id | doaj-art-820658cc635a4c8a8922e31b6b3531f6 |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-820658cc635a4c8a8922e31b6b3531f62025-08-20T03:46:15ZengSpringerDiscover Oncology2730-60112025-07-0116111310.1007/s12672-025-03275-8FKBP10 expression and TP53 mutation predict prognosis and chemotherapy response in triple-negative breast cancerYan Li0Chi Zhang1Jian Chen2Gang Tu3Lingfeng Tang4Department of Breast and Thyroid Surgery, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Breast and Thyroid Surgery, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Breast and Thyroid Surgery, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Breast and Thyroid Surgery, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Breast and Thyroid Surgery, The First Affiliated Hospital of Chongqing Medical UniversityAbstract Background Triple-negative breast cancer (TNBC) lacks targeted therapies. FKBP10 contributes to oncogenesis and chemoresistance. We investigated FKBP10’s prognostic value in TNBC. Methods We retrospectively analyzed 190 TNBC patients receiving neoadjuvant chemotherapy. Patients were stratified by FKBP10 expression (median AOD cutoff) and TP53 status. Cox regression identified prognostic factors for disease-free survival (DFS) and pathological complete response (pCR). Results 34% achieved pCR. High FKBP10 expression correlated with worse DFS (HR = 0.50, 95%CI: 0.26–0.96, P = 0.03). Independent predictors of DFS included: N-stage (P = 0.021), age (P = 0.027), FKBP10/TP53 co-occurrence (P = 0.020), and pCR status (P = 0.005). FKBP10/TP53 co-occurrence predicted poor chemotherapy response (OR = 0.413, P = 0.016). Conclusion FKBP10 overexpression with TP53 mutation predicts poor prognosis and chemoresistance in TNBC. These biomarkers may guide treatment decisions, though prospective validation is needed.https://doi.org/10.1007/s12672-025-03275-8Neoadjuvant chemotherapyBreast cancerFKBP10TP53Prognosis |
| spellingShingle | Yan Li Chi Zhang Jian Chen Gang Tu Lingfeng Tang FKBP10 expression and TP53 mutation predict prognosis and chemotherapy response in triple-negative breast cancer Discover Oncology Neoadjuvant chemotherapy Breast cancer FKBP10 TP53 Prognosis |
| title | FKBP10 expression and TP53 mutation predict prognosis and chemotherapy response in triple-negative breast cancer |
| title_full | FKBP10 expression and TP53 mutation predict prognosis and chemotherapy response in triple-negative breast cancer |
| title_fullStr | FKBP10 expression and TP53 mutation predict prognosis and chemotherapy response in triple-negative breast cancer |
| title_full_unstemmed | FKBP10 expression and TP53 mutation predict prognosis and chemotherapy response in triple-negative breast cancer |
| title_short | FKBP10 expression and TP53 mutation predict prognosis and chemotherapy response in triple-negative breast cancer |
| title_sort | fkbp10 expression and tp53 mutation predict prognosis and chemotherapy response in triple negative breast cancer |
| topic | Neoadjuvant chemotherapy Breast cancer FKBP10 TP53 Prognosis |
| url | https://doi.org/10.1007/s12672-025-03275-8 |
| work_keys_str_mv | AT yanli fkbp10expressionandtp53mutationpredictprognosisandchemotherapyresponseintriplenegativebreastcancer AT chizhang fkbp10expressionandtp53mutationpredictprognosisandchemotherapyresponseintriplenegativebreastcancer AT jianchen fkbp10expressionandtp53mutationpredictprognosisandchemotherapyresponseintriplenegativebreastcancer AT gangtu fkbp10expressionandtp53mutationpredictprognosisandchemotherapyresponseintriplenegativebreastcancer AT lingfengtang fkbp10expressionandtp53mutationpredictprognosisandchemotherapyresponseintriplenegativebreastcancer |