Potential application of the bulk RNA sequencing in routine MPN clinics

Potential application of the bulk RNA sequencing in routine MPN clinics

Abstract Background Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) are chronic hematological malignancies characterized by driver and nondriver mutations, leading to a deregulated immune system with aberrant cytokines and immune cells. Understanding the gene mutation landscape...

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Bibliographic Details
Main Authors: Shenglong Li, Sanyun Wu, Mingli Xu, Xuedong Li, Xuelan Zuo, Yingying Wang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Cancer
Subjects:
Myeloproliferative neoplasms
Bulk RNA sequencing
Gene mutation
Immune landscape
Online Access:https://doi.org/10.1186/s12885-025-13947-x
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